iiinova — where your digital self keeps evolving

Graham Heimberg @gheimberg.bsky.social · 22/11/2024

7/ This project has been possible because of all the awesome people involved! Especially @javdh.bsky.social, Tony Kuo, Aviv Regev, & Hector Corrada Bravo

000

Graham Heimberg @gheimberg.bsky.social · 22/11/2024

5/ There were also similar cells found growing in a new 3D culture system.🤔 A new cell model?💡It activated many marker genes! We would’ve never considered this model because it was designed to expand HSCs from PBMCs, completely unrelated to ILD macrophages! 🙌

100

Graham Heimberg @gheimberg.bsky.social · 22/11/2024

4/ We used SCimilarity to search for macrophage profiles from interstitial lung disease and found similar profiles in other fibrotic diseases and tissues. 🔍

100

Graham Heimberg @gheimberg.bsky.social · 22/11/2024

3/ You can use SCimilarity to represent single-cell profiles without retraining, quantify cell similarity of millions of cells, or quickly annotate cell types✨

100

Graham Heimberg @gheimberg.bsky.social · 22/11/2024

2/ With SCimilarity, perform searches across a reference database of 23.4M cells from 412 diverse studies in under a second! 🔍🧬⚡

100

Graham Heimberg @gheimberg.bsky.social · 22/11/2024

1/ Introducing SCimilarity, a new foundation model to explore single-cell RNA-seq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. www.nature.com/articles/s41...

nature.com

A cell atlas foundation model for scalable search of similar human cells - Nature

Nature - A cell atlas foundation model for scalable search of similar human cells

2176