iiinova — where your digital self keeps evolving

Geremy clair @geremyclair.bsky.social · 20/06/2025

🚀 Off the press! Deep generative AI and multi-omics datasets are revolutionizing drug screening. Check out the findings here: www.nature.com/articles/s41.... It was incredible to be part of this endeavor. Learn more about UNAGI here🐡 🐍: medicine.yale.edu/news-article... @kaminskimed.bsky.social

nature.com

A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases - Nature Biomedical Engineering

UNAGI deciphers cellular dynamics from human disease time-series single-cell data and facilitates in silico drug perturbations to discover drugs potentially active against complex human diseases.

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Geremy clair @geremyclair.bsky.social · 14/05/2025

You could also use a typewriter to type your answer and ask the reviewer if he recommends the use of home-casted gels to perform the western blots.

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Geremy clair @geremyclair.bsky.social · 14/05/2025

Here is a good way to waste $$$ but turn a reviewer a mass spec believer. Buy 3 antibodies: the first well validated, and 2 from « less reputable » suppliers. Then show that WB gives you discrepant results. Now point to the reviewer that antibodies are not more reliable than mass spectrometry.

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Geremy clair @geremyclair.bsky.social · 06/12/2024

New publication 🫁 📊 🔬 ! We performed proteomics and transcriptomics of lung sorted cells from human (0 to 8 years). We discovered new cell markers and pathway modulated during development. A must-read for #teamMassSpec enthusiasts focused on development www.atsjournals.org/doi/abs/10.1...

atsjournals.org

Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis

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Geremy clair @geremyclair.bsky.social · 03/12/2024

4/4 The team identified key EMC3 interacting proteins, including VCP, and demonstrated how the VCP inhibitor CB5083 restores alveolar structure and trafficking in AT2 patient-specific iPSCs 💊.

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Geremy clair @geremyclair.bsky.social · 03/12/2024

3/4 Proteomics revealed that Emc3 depletion fixes vesicle trafficking and mitochondrial dysfunction linked to the mutation. This could be a game-changer for treatment! 🧫

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Geremy clair @geremyclair.bsky.social · 03/12/2024

2/4 In this groundbreaking work by an incredible collaborative team, we used a mouse model to show how the deletion of Emc3 in AT2 cells can rescue defects caused by the I73T mutation. 🐭🔬

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Geremy clair @geremyclair.bsky.social · 03/12/2024

🚨 Exciting new research alert! We're thrilled to have contributed to this work that uncovers the role of EMC3 in managing the SFTPCI73T mutation linked to interstitial lung disease and the role of other genes such as EMC3 and VCP in surfactant trafficking www.jci.org/articles/vie... (a thread 1/4)

jci.org

JCI - EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease

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