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george-austin.bsky.social

@george-austin.bsky.social
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Reposted by @george-austin.bsky.social
Tal Korem @tkorem.bsky.social · 28/11/2025
Out after peer-review: www.science.org/doi/full/10.... Our bottom line stayed: never use leave-one-out cross-validation as it has inherent train-test leakage. Consider our Rebalanced version instead! We now also account for regression and nested cross-validation, with more extensive benchmarking.
science.org
Distributional bias compromises leave-one-out cross-validation
Leave-one-out cross-validation, a common machine learning evaluation method, has a pernicious flaw; a practical fix is presented.
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Reposted by @george-austin.bsky.social
Tal Korem @tkorem.bsky.social · 02/05/2025
Our paper explaining why Gihawi et al. failed to prove an error in the normalization used by the 2020 cancer #microbiome analysis now out as a Matters Arising in @asm.org #mSystems (w/ @george-austin.bsky.social) 🖥️ 🧬 Thread explaining the key points below. journals.asm.org/doi/10.1128/...
journals.asm.org
Compositional transformations can reasonably introduce phenotype-associated values into sparse features | mSystems
Gihawi et al. claim that finding that a transformation turned highly sparse (mostly zero) features into features that are associated with a phenotype is sufficient to conclude that there is informatio...
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Reposted by @george-austin.bsky.social
Tal Korem @tkorem.bsky.social · 27/03/2025
Happy to share DEBIAS-M, our new method for domain adaptation and bias correction in #microbiome data.🧬🖥️ Microbiome data is very variable, with substantial study- and batch-effects. DEBIAS-M corrects these, enabling robust and generalizable analyses. A quick thread: www.nature.com/articles/s41...
nature.com
Processing-bias correction with DEBIAS-M improves cross-study generalization of microbiome-based prediction models - Nature Microbiology
DEBIAS-M corrects technical variability in microbiome data in a manner both interpretable and suitable for machine learning. In extensive benchmarks, DEBIAS-M facilitates robust analyses that generali...
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