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Genoa Instruments @genoainstruments.bsky.social · 02/10/2026

This work highlights the potential of time-resolved detection to provide additional contrast in fluorescence microscopy by separating signals in time. 🎉 Congratulations to all the authors.

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Genoa Instruments @genoainstruments.bsky.social · 02/10/2026

PRISM Add-on was used for confocal time-gated imaging in HeLa cells, enabling selective detection of the long lifetime and improving image contrast.

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Genoa Instruments @genoainstruments.bsky.social · 02/10/2026

Busato et al. developed a new Eu(III)-based luminescent probe for multicolor and time-gated immunofluorescence, exploiting its long emission lifetime to distinguish the probe signal from short lifetime cellular autofluorescence.

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Genoa Instruments @genoainstruments.bsky.social · 02/10/2026

🔬 New publication featuring PRISM Add-on for time-gated imaging. We are pleased to see PRISM Add-on used in a new study published in Chemical & Biomedical Imaging. 📄 Read the full publication: pubs.acs.org/cbihbp/artic...

pubs.acs.org

A Bioconjugable Eu(III)-Based Luminescent Probe for Multicolor and Time-Gated Immunofluorescence

Abstract. We present a π-conjugated ligand endowed with blue emission and the ability to form a self-assembled red-emitting europium(III) complex with a lo

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Genoa Instruments @genoainstruments.bsky.social · 29/09/2026

Missed the live session? The full webinar recording is now available on our LinkedIn page. For any questions about FLIM, FLISM or our technology, contact us at info@genoainstruments.com

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Genoa Instruments @genoainstruments.bsky.social · 29/09/2026

We had a great session exploring Fluorescence Lifetime Imaging Microscopy (FLIM), from its fundamental principles and biological applications to instrumentation and FLISM.

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Genoa Instruments @genoainstruments.bsky.social · 29/09/2026

🔬 Thank you for joining our FLIM webinar! A big thank you to everyone who joined us on Wednesday for “Getting Started with FLIM: From Concepts to Applications.”

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Genoa Instruments @genoainstruments.bsky.social · 22/09/2026

There’s still time to register via LinkedIn. Don’t miss it! 👇 www.linkedin.com/events/getti...

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Genoa Instruments @genoainstruments.bsky.social · 22/09/2026

If you’re interested in FLIM and want to learn more, join us for a practical introduction to the technique — from the fundamentals of fluorescence lifetime to instrumentation, acquisition, and data analysis.

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Genoa Instruments @genoainstruments.bsky.social · 22/09/2026

🔬 JOIN US TOMORROW! Our webinar Getting Started with FLIM: From Concepts to Applications is happening tomorrow! 📅 September 23rd ⏰ 3:00 PM CEST 💻 Online on LinkedIn

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Genoa Instruments @genoainstruments.bsky.social · 08/09/2026

👉 Register for the event via LinkedIn and join us! We look forward to seeing you there! www.linkedin.com/events/getti...

linkedin.com

https://www.linkedin.com/events/gettingstartedwithflim-fromconc7490436873425956864/theater/

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Genoa Instruments @genoainstruments.bsky.social · 08/09/2026

We’ll cover FLIM fundamentals, biological applications, instrumentation and acquisition workflows, and take a look at how FLIM can be combined with Image Scanning Microscopy (ISM).

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Genoa Instruments @genoainstruments.bsky.social · 08/09/2026

Whether you are new to Fluorescence Lifetime Imaging Microscopy (FLIM) or looking to strengthen your understanding of the technique, this webinar will provide a practical introduction to the key concepts you need to get started.

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Genoa Instruments @genoainstruments.bsky.social · 08/09/2026

🔬 IT’S WEBINAR MONTH! We’re getting ready for our upcoming Genoa Instruments webinar: Getting Started with FLIM: From Concepts to Applications. 📅 September 23rd 🕒 3:00 PM CEST 💻 Online

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Genoa Instruments @genoainstruments.bsky.social · 03/09/2026

☀️ Back from the summer break! We hope everyone had a relaxing summer. At Genoa Instruments, we’re back and getting ready for the months ahead. We’ve been working on something new to support FLIM users. We can’t reveal too much just yet, but it’s almost time. 🔬 Something new is coming. Stay tuned.

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Genoa Instruments @genoainstruments.bsky.social · 28/08/2026

📩 Interested in exploring label-free super-resolution imaging for your experiments? Contact us at sales@genoainstruments.com

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Genoa Instruments @genoainstruments.bsky.social · 28/08/2026

🔗 This work was performed as part of the DRUPE project, exploring innovative technologies for precision and sustainable olive growing. Learn more about Genoa Instruments' contribution: www.genoainstruments.com/drupe.html

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Genoa Instruments @genoainstruments.bsky.social · 28/08/2026

📷 In this image, a living olive leaf was imaged using the PRISM Add-on system, exploiting its intrinsic autofluorescence to visualize tissue organization and cellular morphology.

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Genoa Instruments @genoainstruments.bsky.social · 28/08/2026

🌱 What can PRISM approach offer to plant biology? • Label-free imaging. • Up to 2× higher spatial resolution via Image Scanning Microscopy (ISM). • Up to 8× higher signal collection via SPAD-array detection. • Up to 70% less photodamage via gentler illumination conditions.

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Genoa Instruments @genoainstruments.bsky.social · 28/08/2026

This makes autofluorescence imaging particularly attractive for studying living plant samples, where preserving the native state of the tissue is essential.

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Genoa Instruments @genoainstruments.bsky.social · 28/08/2026

🌿 🔬 Label-Free Super-Resolution Imaging in Plant Biology. Plant tissues contain naturally fluorescent molecules that can provide valuable structural and functional information without the need for external fluorescent labels.

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Genoa Instruments @genoainstruments.bsky.social · 20/08/2026

📩 Interested in applying multicolor ISM to your samples? Contact us at sales@genoainstruments.com

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Genoa Instruments @genoainstruments.bsky.social · 20/08/2026

All three fluorescence channels were acquired simultaneously, with CARMA software-controlled laser switching within each pixel dwell time. From individual structures to their spatial relationships, seeing multiple cellular components together can provide a more complete picture of cell organization

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Genoa Instruments @genoainstruments.bsky.social · 20/08/2026

📷 In these HeLa cells, nuclei🟦, microtubules 🟪 and mitochondria 🟨 were imaged with the PRISM Add-on, providing a multicolor super-resolution view of nuclear, cytoskeletal and mitochondrial organization.

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Genoa Instruments @genoainstruments.bsky.social · 20/08/2026

This is where multicolor Image Scanning Microscopy (ISM) can provide additional information. By combining multichannel fluorescence imaging with enhanced spatial resolution, ISM enables a more detailed view of how different cellular components are organized within the same cell.

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Genoa Instruments @genoainstruments.bsky.social · 20/08/2026

Labelling multiple structures at once allows us to visualize their organization and investigate how their distribution and morphology relate to one another. But when cellular structures are densely packed, conventional fluorescence imaging struggles to provide sufficient spatial resolution.

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Genoa Instruments @genoainstruments.bsky.social · 20/08/2026

🔬 Multicolor super-resolved ISM for Cell Biology The cytoskeleton, organelles and nucleus continuously interact to maintain cell function and respond to changes in the cellular environment. This is why multicolor imaging is so important in cell biology.

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Genoa Instruments @genoainstruments.bsky.social · 06/08/2026

💬 What cellular structures or biological processes would you like to investigate with super-resolution ISM? 📩Contact us and let us know at sales@genoainstruments.com

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Genoa Instruments @genoainstruments.bsky.social · 06/08/2026

Whether you are investigating cytoskeletal organization, quantifying morphological changes or studying dynamic cellular processes, improved image quality can provide more reliable and informative data.

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Genoa Instruments @genoainstruments.bsky.social · 06/08/2026

By upgrading a conventional confocal microscope with Image Scanning Microscopy (ISM), PRISM enhances spatial resolution and image contrast, revealing finer structural details while preserving the familiar confocal workflow.

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Genoa Instruments @genoainstruments.bsky.social · 06/08/2026

Visualizing these filamentous networks with high contrast and resolution is essential for studying cellular organization, dynamics and morphological changes. The image below shows actin filaments in a HeLa cell, acquired using the PRISM Add-on from Genoa Instruments.

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Genoa Instruments @genoainstruments.bsky.social · 06/08/2026

🔬 Seeing the cytoskeleton with greater clarity Actin filaments are fundamental components of the cytoskeleton, providing structural support, maintaining cell shape and driving processes such as cell migration, adhesion and contractility.

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Genoa Instruments @genoainstruments.bsky.social · 28/07/2026

Do you want to learn more about our advanced imaging solutions? 📩 Contact us at sales@genoainstruments.com.

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Genoa Instruments @genoainstruments.bsky.social · 28/07/2026

Every PRISM system is the result of continuous design, prototyping, testing and refinement. Each iteration at the optical bench helps improve performance, reliability and usability for advanced microscopy applications. This is part of the daily work at Genoa Instruments.

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Genoa Instruments @genoainstruments.bsky.social · 28/07/2026

At Genoa Instruments, our engineering combines: • Optical design and precision alignment • SPAD-based photon detection • High-speed electronics and synchronization • Real-time acquisition, image reconstruction and analysis software

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Genoa Instruments @genoainstruments.bsky.social · 28/07/2026

🔬 Building an advanced microscopy system requires engineering optical technologies that deliver reliable and high-quality imaging. From optical design to high-speed electronics and real-time acquisition software, every subsystem is engineered to operate as part of a single imaging platform.

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Genoa Instruments @genoainstruments.bsky.social · 23/07/2026

📩 Get in touch to learn more at sales@genoainstruments.com.

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Genoa Instruments @genoainstruments.bsky.social · 23/07/2026

Advantages • Deterministic hardware-based control • Low-latency signal generation and acquisition • Independent analog and digital I/O channels for flexible configurations (7 analog: 5 outputs, 2 inputs; 7 digital: 5 outputs, 2 inputs) • Integration with PRISM, CARMA and FPGA platforms

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Genoa Instruments @genoainstruments.bsky.social · 23/07/2026

Whether you're building a new system or upgrading an existing one, AFE PHOTON-DRIVE integrates seamlessly with Genoa Instruments' PRISM platform and CARMA software and is compatible with FPGA solutions, making it easy to incorporate into established research workflows.

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Genoa Instruments @genoainstruments.bsky.social · 23/07/2026

Its firmware-less architecture minimizes latency and delivers deterministic hardware control, while independent asynchronous channels provide the flexibility required for complex experimental setups.

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Genoa Instruments @genoainstruments.bsky.social · 23/07/2026

⚙️ Developing or upgrading a custom microscopy system? AFE PHOTON-DRIVE, our Analog Front End for advanced microscopy, provides hardware control for high-speed signal generation and acquisition, helping synchronize detectors, scanners and other instrumentation.

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Genoa Instruments @genoainstruments.bsky.social · 21/07/2026

For Genoa Instruments, as project coordinator, IMPACT is an important step in extending technologies originally developed for scientific research toward real clinical applications, helping bridge the gap between photonics, advanced microscopy and precision medicine.

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Genoa Instruments @genoainstruments.bsky.social · 21/07/2026

We are excited to share the launch of the IMPACT website. The project is a major initiative that aims to transfer optical super-resolution microscopy from the laboratory toward diagnostic and preclinical applications in oncology and histopathology.

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Genoa Instruments @genoainstruments.bsky.social · 21/07/2026

🚀 The IMPACT project website is now live! IMPACT brings together optical innovation, cancer biology, clinical pathology and artificial intelligence to develop a new generation of high-resolution tissue imaging technologies. www.genoainstruments.com/impact/#rese...

genoainstruments.com

IMPACT Project | Advanced Microscopy for Precision Pathology

A FISA-funded research project bringing advanced optical microscopy, cancer biology, clinical pathology and AI closer to precision tissue analysis.

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Genoa Instruments @genoainstruments.bsky.social · 16/07/2026

With CARMA FLIM, researchers can visualize lifetime maps as they acquire data, enabling immediate assessment of sample and faster experimental decisions. 🎥 Watch the video to see CARMA FLIM in action and get in touch at sales@genoainstruments.com to learn more and to request a live demo.

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Genoa Instruments @genoainstruments.bsky.social · 16/07/2026

The power of fluorescence lifetime image scanning microscopy (FLISM) comes not only from the microscope but also from the software that controls the acquisition, synchronizes the lasers and delivers real-time fluorescence lifetime information during experiments.

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Genoa Instruments @genoainstruments.bsky.social · 16/07/2026

Fluorescence lifetime adds quantitative information that cannot be captured by intensity alone.

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Genoa Instruments @genoainstruments.bsky.social · 16/07/2026

Check-out the new CARMA FLIM software in action during acquisition.

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Genoa Instruments @genoainstruments.bsky.social · 13/07/2026

We wish all the organizers, speakers and participants an inspiring, collaborative and highly productive conference! 🚀

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Genoa Instruments @genoainstruments.bsky.social · 13/07/2026

We are pleased to support an event that brings together researchers working at the forefront of biophysics and advanced imaging. 📅 28th SIBPA Conference 📍 Catania, Italy

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