Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME...

Schröder et al. describe the molecular functions of the Tbx factor Eomes, which, together with the SWI/SNF chromatin remodeling complex, establishes enhancer accessibility at mesoderm and endoderm (ME) genes during lineage specification of pluripotent cells. Eomes enables broad ME lineage competence for gene activation that relies on additional signal-induced transcription factors.