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Reposted by Gabriel da Silva

Catarina Marques @marquescata.bsky.social · 01/10/2026

@emmamariebriggs.bsky.social and I paired up for a scRNAseq exp eons ago to look at cell cycle regulated genes in Leish... The analysis evolved over time, incorporated other datasets in the lab, and looked for life cycle forms in vitro. We now bring you what we found! www.biorxiv.org/content/10.6...

biorxiv.org

Single-cell transcriptomics reveals life cycle and cell cycle gene expression dynamics during in vitro growth of two Leishmania species

Leishmania species are transmitted between mammals by sand flies, within which they undergo a complex developmental programme involving transitions between replicative and non-replicative life cycle f...

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Gabriel da Silva @gabriel93dasilva.bsky.social · 21/08/2026

This week I had the opportunity to present some of our data about Origin Recognition Complex (ORC) interactome in T. Brucei at #ICOPA2026 in Montreal/CA. Incredible meeting with fine scientists from all over the world 🌎, with exciting discussions from all fields of Parasitology! #UoG #ICOPA2026

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Gabriel da Silva @gabriel93dasilva.bsky.social · 08/12/2025

I am trilled to share my latest publication where we contribute to the knowledge of how ATR kinase, a DNA damage response factor, modulates DNA replication timing during stress in Leishmania major. Huge thanks to @rmc9z.bsky.social, @LuizTosi and the collaborators for the support and guidance!

dx.plos.org

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major

Author summary A series of protein kinases act at the pinnacle of eukaryotic cells’ DNA damage response, organising and guiding repair. One such kinase is ATR, which recognises single-stranded DNA for...

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Reposted by Gabriel da Silva

Jeziel D. Damasceno @jezieldamasceno.bsky.social · 06/08/2025

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. www.cell.com/cell-reports...

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