α-synuclein clearance and propagation are mediated by glymphatic function and aquaporin-4 mis-localization observed in the presence of human synucleinopathy may contribute to the development and propagation of Lewy body pathology
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Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation
Braun et al. report that human synucleinopathy is associated with mislocalization of the astroglial water channel aquaporin-4 and glymphatic clearance of a