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Francesca Chandler

@francescachandler.bsky.social

Reposted by Francesca Chandler

Elton Zeqiraj @zeqiraj.bsky.social · 17/03/2025

A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch. youtu.be/wuFVeW6eCPg?...

youtu.be

Molecular Glues: drugging the undruggable

YouTube video by Phospho Biomedical Animation

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Reposted by Francesca Chandler

Elton Zeqiraj @zeqiraj.bsky.social · 17/03/2025

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

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Francesca Chandler @francescachandler.bsky.social · 17/03/2025

Very happy to share the work from my PhD is out today in @naturesmb.bsky.social ! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...

nature.com

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology

The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

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