Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying meta...

The global increase in life expectancy has resulted in a growing proportion of older individuals at increased risk of severe disease outcomes following viral infections. CD8+ T cells play a vital role...

Circadian rhythms orchestrate a wide array of behavioral and physiological functions, coordinating cellular and organismal processes on an approximate…

A blood protein measured in midlife may predict future dementia risk and reveal immune pathways tied to vascular brain damage.

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Microplastics and nanoplastics (MNPs) have emerged as pervasive dietary contaminants, yet their implications for human health remain poorly defined. This review synthesized current evidence on MNP int...

Abstract. Philosophy of biology has the potential to contribute to biology by improving scientific reasoning. However, this potential is largely unrealized

The AMP-activated protein kinase (AMPK) may have arisen soon after the endosymbiosis event that generated eukaryotes, perhaps to allow the archaeal host to communicate its requirements for ATP to the ...

Long-term in vivo production of therapeutic proteins and development of vaccines that elicit protective levels of broadly neutralizing antibodies (bNAbs) against major pathogens face challenges. In th...

Here they show that extended serial somatic cell cloning imposes a threefold increase in de novo mutations compared to natural reproduction, progressively reducing birth rates and ultimately limiting ...

Repeated cloning cannot be sustained indefinitely in mammals, according to the findings of a twenty-year study on mice conducted in Japan. Serial cloning of mice led to an accumulation of lethal DNA m...

A la retinosi pigmentària, una malaltia rara de la visió, els pacients noten els primers símptomes al final de l'adolescència. El que s'inicia com ceguesa nocturna i visió en túnel desemboca en cegues...

Liu et al. investigated the relationship between two hallmarks of aging (chronic inflammation and DNA methylation alterations) in four independent cohorts covering different ages and health conditions...

Liu et al. investigated the relationship between two hallmarks of aging (chronic inflammation and DNA methylation alterations) in four independent cohorts covering different ages and health conditions...

Background and Aims The current study aimed to assess the associations between (i) total and specific sugar intake, (ii) dietary exposures that met Global Burden of Diseases, Injuries, and Risk Fact...

The New England Centenarian Study (NECS) provides a unique resource for the study of extreme human longevity (EL). To gain insight into biological pathways related to EL, chronological age and surviva...

The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

Studies have revealed an association between elevated neuronal cholesterol and neuronal dysfunction, in particular, mitochondrial impairment. However,…

This translational science review summarizes current evidence about the primary biologic pathways by which obesity may promote development of cancer and interventions that may reduce obesity-associate...

Paradigm clash plays a crucial role in science by strengthening existing conceptual models or facilitating adoption of more useful ones. Here, I argue that this salutary process tends to stagnate in t...

Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.

Endothelial cells (ECs) are key metabolic gatekeepers, yet their role in metabolic health remains unclear. Given their central involvement in energy m…

This double-controlled study, incorporating pre- versus post-infection and uninfected symptom data, found a low risk of PCC among a community-dwelling adult population infected during the autumn 2023 ...

Redox therapy may restore brain energy deficits, underscoring the need for in vivo biomarkers to guide personalized treatments.

Abstract. Foods and beverages sweetened with non-nutritive sweeteners (NNSs) are increasingly common in modern diets and widely promoted as healthy alterna

Healthy dietary patterns are linked to longer life expectancy and can be adapted to personal preferences and cultural traditions.

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the major omega-3 polyunsaturated fatty acids (ω-3 PUFAs), derived from fish oil are widely used as dietary supplements and are United State...

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

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The human gut microbiome is important for host health, yet over 60% of gut species remain uncultured and inaccessible to experimental manipulation. He…

L'obesitat no és una fallada de la voluntat, com està estigmatitzada socialment, ni un problema individual: és una malaltia amb arrels complexes en un cervell adaptat a sobreviure en l'escassetat.

This prospective cohort study investigates whether coffee and tea intake are associated with dementia risk and cognitive function in female participants from the Nurses’ Health Study and male particip...

Large-scale computational and in vitro analyses identify commensal type III secretion systems and substrates in the human gut microbiome that can interact with human proteins to modulate immune pathwa...

AbstractContext. Coffee contains various bioactive compounds, including chlorogenic acids (CGAs), caffeine, and hydroxyhydroquinone (HHQ), which may differ

Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA- and nDNA-ba....

Genetic variants altering brain function have been considered the primary cause of many neurological disorders. Therefore, current therapeutics target…

In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...

BACKGROUND: Depression is linked to major adverse cardiac events (MACE), yet the role of stress-related neural activity–previously implicated in stress and anxiety—in mediating this association remain...

Chronic overnutrition promotes excessive hepatic triglyceride accumulation, subsequently leading to insulin resistance and systemic metabolic dysfunction.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Hydrogen sulfide is a gasotransmitter with biological functions, including roles in antioxidant defenses, mitochondrial bioenergetics, and cellular si…