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FOR5159

@for5159.bsky.social
41 followers 76 following 397 posts

We're a group of enthusiastic scientists aiming to uncover the dynamic principles of prefrontal processing underlying cognitive flexibility!

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Reposted by FOR5159
Armin Lak @laklab.bsky.social · 18/02/2025
This review has turned into my go-to paper for rodent PFC circuit. Useful in the lab and for teaching. Thanks @panastasiades.bsky.social and @carterlab.bsky.social for writing this. www.cell.com/trends/neuro...
cell.com
Circuit organization of the rodent medial prefrontal cortex
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons a...
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FOR5159 @for5159.bsky.social · 15/03/2025
Congratulations to the authors!
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FOR5159 @for5159.bsky.social · 15/03/2025
Literature highlight, this week from our consortium! Muyers et al. used an olfaction-guided spatial memory task in mice to show that prefrontal neurons encode both generalized and trajectory-specific aspects of task structure. www.cell.com/cell-reports...
cell.com
Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...
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FOR5159 @for5159.bsky.social · 10/01/2025
Congratulations to the authors!
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FOR5159 @for5159.bsky.social · 10/01/2025
choice www.nature.com/articles/s41593-024-…
nature.com
Context-dependent decision-making in the primate hippocam...
The brain uses different valuation schemes across context...
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FOR5159 @for5159.bsky.social · 10/01/2025
Literature highlight of the week: Elston and Wallis used a state-dependent choice task in monkeys to show that the hippocampus relays context-based information via theta waves to the orbitofrontal cortex, which informs valuation and...
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FOR5159 @for5159.bsky.social · 03/01/2025
Congratulations to all the authors!
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FOR5159 @for5159.bsky.social · 03/01/2025
elegans. www.cell.com/cell/fulltext/S0092-86…
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FOR5159 @for5159.bsky.social · 03/01/2025
Literature Highlight of the Week: Almoril-Porras and Calvo et al. demonstrate the necessity of gap junctions in the temperature gradient migration strategies of C....
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FOR5159 @for5159.bsky.social · 31/12/2024
Congratulations to all the authors!
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FOR5159 @for5159.bsky.social · 31/12/2024
Mugan et al. investigate the effects of environmental complexity on ensemble firing and local field potential in the dmPFC, hippocampus, and dlstriatum of freely moving rats during a foraging task. www.sciencedirect.com/science/artic…
sciencedirect.com
ScienceDirect
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FOR5159 @for5159.bsky.social · 20/12/2024
Congratulations to all the authors!!!
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FOR5159 @for5159.bsky.social · 20/12/2024
Qian et al. explore the dynamic interplay between relevant information and distractor representations in the lateral prefrontal cortex (LPFC) and prearcuate cortex (PAC) of macaque monkeys. www.jneurosci.org/content/early/202…
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FOR5159 @for5159.bsky.social · 07/12/2024
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FOR5159 @for5159.bsky.social · 07/12/2024
Literature highlight of the week: Chen et al. explore thalamic representation and thalamocortical interactions that contribute to hierarchical cognitive control in humans journals.plos.org/plosbiology/artic…
journals.plos.org
The thalamus encodes and updates context representations ...
The cortico-striatal-thalamic circuit is involved in upda...
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FOR5159 @for5159.bsky.social · 01/12/2024
Congratulations to the authors!
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FOR5159 @for5159.bsky.social · 01/12/2024
Literature highlight of the week: Xu et al. show how robustness and sensitivity coexist in neural networks by analyzing neural dynamics in the monkey prefrontal cortex and using comptational approaches www.pnas.org/doi/epub/10.1073/pnas.…
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FOR5159 @for5159.bsky.social · 23/11/2024
Congratulations to the authors @toonvdm @GiovanniPezzulo
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FOR5159 @for5159.bsky.social · 23/11/2024
www.nature.com/articles/s41467-024-…
nature.com
A hierarchical active inference model of spatial alternat...
How cognitive maps of physical and task space interact wh...
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FOR5159 @for5159.bsky.social · 23/11/2024
Literature highlight of the week: Van de Maele et al. propose a hierarchical active inference model clarifying how the hippocampal-medial prefrontal cortex circuit solves spatial interaction tasks by bridging physical and task-space maps....
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FOR5159 @for5159.bsky.social · 15/11/2024
Congratulations to the authors! @HalassaLab
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FOR5159 @for5159.bsky.social · 15/11/2024
change www.nature.com/articles/s41586-024-…
nature.com
Prefrontal transthalamic uncertainty processing drives fl...
By examining neural responses from tree shrews performing...
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FOR5159 @for5159.bsky.social · 15/11/2024
Literature highlight of the week: Lam et al. used a decision task with rule reversals in tree shrews and found that relevant thalamic neurons drive prefrontal reconfiguration following a reversal by attributing errors to an environmental...
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FOR5159 @for5159.bsky.social · 08/11/2024
Congratulations to the authors!
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FOR5159 @for5159.bsky.social · 08/11/2024
tasks www.nature.com/articles/s41586-024-…
nature.com
A cellular basis for mapping behavioural structure - Nature
Mice generalize complex task structures by using neu...
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FOR5159 @for5159.bsky.social · 08/11/2024
Literature highlight of the week: El-Gaby et al. identify an algorithm that relates medial frontal cortex role in schema formation and sequence memory, by internally organizing mnemonic activity according to an abstract structure shared by different...
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FOR5159 @for5159.bsky.social · 01/11/2024
Congratulations to the authors! @adredish
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FOR5159 @for5159.bsky.social · 01/11/2024
cortex www.sciencedirect.com/science/artic…
sciencedirect.com
ScienceDirect
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FOR5159 @for5159.bsky.social · 01/11/2024
Literature highlight of the week: Mugan et al. show that complex naturalistic environments modulate decision-making strategies, neural representations, and interactions among the hippocampus, dorsolateral striatum, and dorsomedial prefrontal...
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FOR5159 @for5159.bsky.social · 27/10/2024
Congratulations to all authors!
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FOR5159 @for5159.bsky.social · 27/10/2024
Literature highlight of the week: Hansen et al. show that multiple organizational features of cortical activity can be traced back to the brainstem and that cortical functional architecture reflects brainstem influence. www.nature.com/articles/s41593-024-…
nature.com
Integrating brainstem and cortical functional architectur...
Hansen et al. used in vivo functional imaging of the huma...
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FOR5159 @for5159.bsky.social · 18/10/2024
Congratulations to the authors! @jonathan_daume @UeliRutishauser @AMamelak
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FOR5159 @for5159.bsky.social · 18/10/2024
encoding. www.cell.com/neuron/fulltext/S0896-…
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FOR5159 @for5159.bsky.social · 18/10/2024
Literature highlight of the week: Daume et al., show that activity of hippocampal neurons that are selective for specific image categories in a task performed by humans during working memory maintenance predicts the success of long-term memory...
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FOR5159 @for5159.bsky.social · 11/10/2024
Congratulations to the authors! @HalassaLab @GuangyuRobert
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FOR5159 @for5159.bsky.social · 11/10/2024
www.nature.com/articles/s41467-024-…
nature.com
Rapid context inference in a thalamocortical model using ...
The neural mechanism responsible for context inference re...
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FOR5159 @for5159.bsky.social · 11/10/2024
Literature highlight of the week: Zheng et al. show that The MD enhances context-relevant recurrent inputs and suppresses context-irrelevant neuronal activities in PFC neurons, making the PFC modular for different temporal contexts...
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FOR5159 @for5159.bsky.social · 04/10/2024
Congratulations to all the authors!
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FOR5159 @for5159.bsky.social · 04/10/2024
memory. www.science.org/doi/10.1126/science…
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FOR5159 @for5159.bsky.social · 04/10/2024
Literature highlight of the week: Tian et al. shed light on the neural processes underlying the mental manipulation of multiple items with different ordinal ranks in working...
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FOR5159 @for5159.bsky.social · 27/09/2024
Congratulations to all the authors!
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FOR5159 @for5159.bsky.social · 27/09/2024
Literature highlight of the week: Tang et al. study the roles of the orbitofrontal cortex (OFC), ventral striatum (VS), amygdala (AMY), and mediodorsal thalamus (MDt) in symbolic outcome learning. www.sciencedirect.com/science/artic…
sciencedirect.com
ScienceDirect
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FOR5159 @for5159.bsky.social · 20/09/2024
Congratulations to the authors! @ccplab_wustl
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FOR5159 @for5159.bsky.social · 20/09/2024
humans www.jneurosci.org/content/44/38/e03…
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FOR5159 @for5159.bsky.social · 20/09/2024
Literature highlight of the week: Crawford et al. use two distinct versions of a cognitive effort decision-making paradigm during fMRI and show that the dorsal anterior cingulate cortex is the key locus of cognitive effort-based decision-making in...
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FOR5159 @for5159.bsky.social · 13/09/2024
Congratulations to the authors!
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FOR5159 @for5159.bsky.social · 13/09/2024
Literature highlight of the week: Laquitaine et al. reveal the neural and computational mechanisms underlying switching behaviors in humans www.nature.com/articles/s41467-024-…
nature.com
Optimal level of human intracranial theta activity for be...
Direct electrophysiological recordings in the human prefr...
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FOR5159 @for5159.bsky.social · 06/09/2024
Congratulations to the authors!
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FOR5159 @for5159.bsky.social · 06/09/2024
Literature highlight of the week: Gava et al. show that plastic organization of hippocampal coactivity supports a network trade-off between robust and flexible computations. www.science.org/doi/10.1126/science…
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FOR5159 @for5159.bsky.social · 30/08/2024
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