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Background The results of randomized controlled trials (RCTs) regarding the effect of vitamin D supplementation on mortality reduction are conflicting. Objective The aim of this study was to assess.....

Société Française de Pharmacologie et de Thérapeutique

Société Française de Pharmacologie et de Thérapeutique

Société Française de Pharmacologie et de Thérapeutique

Société Française de Pharmacologie et de Thérapeutique

Société Française de Pharmacologie et de Thérapeutique

Société Française de Pharmacologie et de Thérapeutique

The recent decision to establish a single pivotal trial as the default evidentiary standard for Food and Drug Administration (FDA) approval marks a substantive shift in the architecture of regulatory....

Background The systematic conversion of adverse drug reactions (ADRs) into new therapeutic indications represents one of the oldest and most productive sources of repositioned drugs; however, it has...

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Background Midazolam (MDZ) is used for sedation in critically ill patients. Although previous studies have examined MDZ pharmacokinetics in ICU patients, the differential effects of acute kidney inj...

Cardiovascular complications of diabetes mellitus (DM) are responsible for morbidity and mortality in DM patients. Recent evidence highlights the pathophysiological role of the renin-angiotensin-ald...

The current and former editors-in-chief of the Fundamental & Clinical Pharmacology journal share their experience and perspectives regarding the present landscape of scientific publishing and the cha...

This study aimed to evaluate whether TAAR1 (trace amine–associated receptor 1)–associated trace amines (β-phenylethylamine, tryptamine, octopamine, tyramine, and N-methyltyramine) produced cutaneous ....

Société Française de Pharmacologie et de Thérapeutique

Purpose Lower extremity ischemia-reperfusion injury (IRI) triggers systemic inflammation and oxidative stress, causing myocardial remote ischemia-reperfusion injury (MIRI). Current treatments are li...

Colorectal cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the need for novel therapeutic agents with multitarget anticancer activity. Probucol is a pheno...

The effects of obesity on the vasculature and perivascular adipose tissue (PVAT) function vary according to the vascular territory. Nebivolol is a third-generation β-blocker that exerts vasculoprotec...

Background Ketamine is increasingly prescribed in an off-label manner to treat psychiatric disorders, raising concerns about direct-to-consumer advertising and the proliferation of clinics offering ...

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Société Française de Pharmacologie et de Thérapeutique

Background There is a complex link between environmental factors, anxiety levels, and ethanol consumption. Social conditions such as loneliness, peer influence, and housing environment shape drinkin...

Société Française de Pharmacologie et de Thérapeutique

Background Visceral hypersensitivity and impaired intestinal barrier function are hallmark features of irritable bowel syndrome (IBS), linked to activation of corticotropin-releasing factor (CRF), T...

Topics for this call for papers include but are not restricted to:

Objective The objective of this study is to evaluate the influence of alogliptin treatment on the healing process of traumatic oral ulcers. Methods Four experimental groups were used: control grou...

Resistance to B-Raf inhibitors in melanoma poses a significant challenge to effective treatment. This study investigates the synergistic effects of capivasertib, an Akt pathway inhibitor, in combinat...

Société Française de Pharmacologie et de Thérapeutique

Background The soluble guanylate cyclase (sGC)/GMPc pathway plays an important in pulmonary arterial hypertension (PAH). Objective We investigated whether trans-4-methoxy-β-nitrostyrene (T4MN), a ...

Cocaine use has increased both globally and nationally. This trend is accompanied by a rise in clinical complications. The objective of our study was to identify factors observed to be associated wit...

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Background Repositioning offers a cost-effective approach to discovering new therapeutic applications for existing medications. Ambroxol, primarily used as a mucolytic for respiratory diseases, has ...

Introduction The French National Agency for Medicines and Health Products Safety implemented in 2021 a nationwide experimentation for medical cannabis (MC), designed to assess the feasibility of imp...

Hyoscine butylbromide (HB), popularly known as Buscopan, is a common anticholinergic antispasmodic used worldwide for gastrointestinal disorders. While the interaction between the cholinergic system ...

Background Sodium glucose co-transporter type 2 inhibitors (SGLT2i) were initially developed as glucose-lowering drugs for diabetic patients. A few years after their market authorization in Europe, ...

Background Statin-induced liver injury is frequent and usually not severe. The aim of the present study was to describe the safety of statin rechallenge after atorvastatin-induced liver injury becau...

Background Dupilumab is reimbursed in France for adult patients with moderate-to-severe atopic dermatitis (AD), in cases of failure, intolerance or contraindication to cyclosporin A (CsA). The Frenc...

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