iiinova — where your digital self keeps evolving

EVOQUANT @evoquant.bsky.social · 21/04/2026

Heading to Stanford next week for #SDDS2026. In 7 months, Evoquant has built: - A 5.2M biosynthetic gene cluster atlas - An AI platform predicting natural product–target interactions - A wet-lab pipeline with confirmed bioactivity in 6/6 validation cases (15 in progress) 🧵

"A Platform for the Discovery of Novel Microbial Natural Product Chemical Scaffolds and Their Biological Targets"

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EVOQUANT @evoquant.bsky.social · 24/03/2026

The biosynthetic gene cluster universe (5 million BGCs)

Graph depiction the relation of 5 million BGCs

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EVOQUANT @evoquant.bsky.social · 27/02/2026

First extracts went out for antibiotic testing this week. Still waiting for some additional pipettes from Thermo Fisher (to the point they are sending loaners in the meantime) at which point we can finally start our anticancer and immune modulator assays.

Photo of PCR plate with chemical extracts

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EVOQUANT @evoquant.bsky.social · 13/02/2026

Claude is in a tizzy

$Given the user says both should be int, and chembl_id is a string, the molecule uid should likely be molregno. But in load_molecules, chembl_id is renamed to uid and used throughout. Let me check the compound section where ChemblMolecule(properties={"uid": row.chembl_id}) is used — that's a string. The user wants int, so these should use molregno instead, or the chembl_id should not be renamed. Actually, re-reading: the user is just saying the types are int — meaning str() wrapping on TAXID uid is wrong, and the chembl_id rename to uid in molecules is wrong (should keep molregno as uid). But wait — in the original code, molecules used chembl_id as uid too. And in compounds, ChemblMolecule(properties={"uid": row.chembl_id}) uses the string chembl_id.$

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EVOQUANT @evoquant.bsky.social · 06/02/2026

Not enough people seem to be concerned about the cost of owning computers right now. The price of the RAM in Evoquant's workstation computer:

Alt text: Line chart showing a two-year price history for a computer component, with prices around $250–$320 through 2024–2025 before sharply rising above $1,100 by early 2026.

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EVOQUANT @evoquant.bsky.social · 30/01/2026

Evoquant's first set of bacterial strains are growing. We now have several strains in culture as we begin evaluating our novel strategy for obtaining bioactive and novel natural products. Photo is of one of the strains growing on a minimal agar media.

Photo of bacteria colonies growing on agar

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EVOQUANT @evoquant.bsky.social · 16/09/2025

🚀 Evoquant has been awarded a $300k Small Business Grant from the National Institutes of Health for our project: "Leveraging Large-Scale Bioinformatics & AI for Natural Product Drug Discovery and Target Selection" Hitting the ground running 🏃and excited for the year to come!

Public Health Relevance Statement
This research addresses challenges in predicting bioactivity in natural product drug discovery by leveraging advanced AI, computational biology, and multi-omics knowledge graphs. This approach has the potential to accelerate the discovery of new, effective drugs for treating a range of conditions, including cancer, infections, and immune-related diseases, by identifying promising leads that could inform the next generation of therapeutics.

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