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Reposted by Antho Leon

Chourrout lab @appygenetics.bsky.social · 18/08/2025

Check the last preprint from @simonhenriet.bsky.social & colleagues‬. By studying appendicularians, they revealed the events that permitted non-canonical splicing in these organisms: . Duplication & divergence of U2AF splicing factors . Gain & loss of chemical modifications on the spliceosomal RNA

biorxiv.org

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and re-patterning of snRNA m6A modification

In eukaryotes, splicing is a critical step of gene expression that produces transcripts competent for protein synthesis by removing introns from pre-mRNA. The spliceosome defines target splice sites b...

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