iiinova — where your digital self keeps evolving

Reposted by Everett Moding, MD, PhD

Stanford Radiation Oncology @stanfordradonc.bsky.social · 06/08/2025

We are thrilled to share that Everett Moding, MD, PhD, Assistant Professor of Radiation Oncology, has received a MERIT R37 Award from the NIH! This award is a long-term grant for investigators with outstanding research accomplishments and high productivity. Congratulations!

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Reposted by Everett Moding, MD, PhD

Steven Artandi @stevenartandi.bsky.social · 23/05/2025

SCI member @everettmoding.bsky.social & others demonstrate that radiation therapy exerts selective pressures on undifferentiated pleomorphic sarcomas and suggest that targeting radioresistant subclonal populations could improve outcomes after radiotherapy. aacrjournals.org/cancerres/ar...

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Reposted by Everett Moding, MD, PhD

Stanford Radiation Oncology @stanfordradonc.bsky.social · 01/05/2025

Congratulations to @everettmoding.bsky.social and colleagues for being featured online at the @theaacr.bsky.social for their study “Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer.” aacrjournals.org/cancerdiscov...

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

Congrats again to Faith Ryu on the gorgeous cover and our amazing team in the lab (Erik Blomain, Shaghayegh Soudi, Ziwei Wang, Anish Somani, and many more!). Thank you to all of our collaborators and grant support for making this possible! (8/8)

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

Key takeaway ✅: We think targeting resistant subclones will be critical to improve the response of sarcomas and other cancers to radiotherapy, and we are optimistic that tools like ctDNA analysis can help us identify approaches to help radiation kill these cells. (7/8)

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

Finally, we demonstrated that circulating tumor DNA can accurately measure subclonal architecture and non-invasively monitor sarcoma evolution during radiotherapy. (6/8)

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

By analyzing genes mutated in radiosensitive subclones that contracted during radiotherapy, we observed an enrichment in mutations affecting the calcium signaling pathway. Inhibiting calcium transporters made sarcoma cells more sensitive to radiotherapy. (5/8)

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

Using metrics of genetic divergence between regions to measure selection pressure, we found that radiotherapy increased evolutionary selection and led to the expansion of resistant subclonal cancer cells. (4/8)

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

We observed evidence of strong selection during sarcoma development with most untreated UPS displaying initial linear evolution followed by branching evolution later in tumor development. (3/8)

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Everett Moding, MD, PhD @everettmoding.bsky.social · 17/03/2025

First post on @bsky.app to share that our study made the cover of @theaacr.bsky.social Cancer Research! Congrats Faith Ryu on this beautiful artwork showing the effect of #radiotherapy on #sarcoma evolution. A 🧵 of key findings from the most recent story from the lab. (1/8)

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