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European Journal of Neurology @europeanjournalofneurology.ean.org · 8h

🌊 Emerging evidence suggests transcranial ultrasound stimulation may drive sustained neural remodeling raising the possibility that it could eventually contribute to disease-modifying strategies. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 18/10/2026

💤 In a longitudinal cohort of presymptomatic carriers of ALS-associated gene mutations followed over 2.3 ± 1.5 years, sleep alterations worsened at follow-up for both macro- and microarchitecture sleep. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 17/10/2026

🩻 In 52 adults with complete thoracic SCI vs 55 matched controls, cervical morphometry at C2–C3 showed significantly reduced cross-sectional area (CSA) and AP/RL diameters, consistent with remote atrophy, and increased eccentricity. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 15/10/2026

💊 A German–Austrian panel of 18 neurologists provides practical recommendations for managing active gMG in adults, focusing on C5-I (eculizumab, ravulizumab, zilucoplan) and FcRn-I (efgartigimod, rozanolixizumab). 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 13/10/2026

🤖 About 80% of people with epilepsy live in low-and-middle-income countries where the treatment gap is high. AI may help address that through scalable, low-cost solutions for diagnosis, investigation, management, and monitoring 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 10/10/2026

🚑 In 4,854 neurological visits, seizures and headaches comprised 64% of chief complaints. Neurological patients had a nearly fivefold increased risk of requiring immediate lifesaving interventions compared to non-neurological patients. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 30/09/2026

Check out the September issue of European Journal of Neurology! 📚 Read now: onlinelibrary.wiley.com/toc/14681331... #EurJNeurol #Neurology #EJoN @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 28/09/2026

🦴 In 30 patients with unexplained facial pain, internal jugular vein entrapment caused superior petrosal sinus dilation and spinal trigeminal nucleus venous congestion. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 27/09/2026

🌍 The EAN Environmental Influences in Neurology Task Force outlines core concepts and 10 strategic priorities adapted from the WHO framework to build climate-resilient neurology and safeguard brain health. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #BrainHealth #ClimateChange

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European Journal of Neurology @europeanjournalofneurology.ean.org · 25/09/2026

🧠 Is PLS purely a motor disorder? A population-based registry study reveals cognitive and/or behavioral impairment in nearly 30% of 32 PLS patients at diagnosis, predominantly affecting executive function and social cognition. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #PLS

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European Journal of Neurology @europeanjournalofneurology.ean.org · 23/09/2026

🏥 The FERES initiative demonstrates that large-scale, multinational stroke research and benchmarking can be conducted in Europe using a privacy-preserving federated approach. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Stroke

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European Journal of Neurology @europeanjournalofneurology.ean.org · 21/09/2026

🛡️ Does adult thymectomy increase long-term cancer or mortality risk? In a 10-year propensity-matched cohort study, thymectomy was not associated with excess mortality or extrathymic malignancy compared to cardiothoracic surgery controls 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 19/09/2026

🔬 A Belgian multidisciplinary consensus establishes a stepwise diagnostic pathway integrating blood-based biomarkers, CSF, and amyloid-PET to ensure accurate, timely, and equitable early-stage diagnosis. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #AlzheimersDisease #Dementia

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European Journal of Neurology @europeanjournalofneurology.ean.org · 17/09/2026

⚡ Evaluating diagnostic rigor in CIDP: In 339 patients and 339 controls, the revised 2021 EAN/PNS criteria demonstrated higher specificity (86% vs 78%) for definite/probable CIDP compared to the 2010 EFNS/PNS guidelines. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 15/09/2026

🩸 Arterial pathology in Neuro-Behçet's syndrome may be more common than recognized. Vessel wall imaging revealed arterial involvement in 41% of patients, predominantly in the posterior circulation with a concentric thickening pattern. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 12/09/2026

💊 In the prospective INLEVO-LIFE PD study, inhaled levodopa (CVT-301) enhanced health-related quality of life (PDQ-39) and reduced daily OFF time by 1.6 hours. Adverse events related to CVT-301 were reported in 35% of the patients. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 10/09/2026

🤖 The new EAN Task Force on AI launches a multidisciplinary initiative featuring a modular European educational curriculum, survey-driven gap analysis, and tailored ethical-regulatory guidelines. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #ArtificialIntelligence #DigitalHealth

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European Journal of Neurology @europeanjournalofneurology.ean.org · 31/08/2026

Check out the August issue of European Journal of Neurology! 📚 Read now: onlinelibrary.wiley.com/toc/14681331... #EurJNeurol #Neurology #EJoN @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 29/08/2026

🧠 In a target trial emulation direct MT was not non-inferior to IVT + MT treatment beyond 4.5 h from symptom onset or at wake-up, with IVT before MT yielding higher successful recanalization rates. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Stroke #Thrombectomy #Neurology

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European Journal of Neurology @europeanjournalofneurology.ean.org · 27/08/2026

🗣️ Intensive speech-language therapy significantly improves post-stroke dysphagia. While adjunctive tDCS did not show an overall additional benefit, exploratory findings suggest it may help patients with infratentorial strokes. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 25/08/2026

📚 Read the recently published article "Neuropsychiatric Adverse Events Associated With Foslevodopa/Foscarbidopa Continuous Subcutaneous Infusion in Clinical Practice: A Multicenter Study" by Campo-Caballero & Rodriguez-Antiguedad et al.: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 25/08/2026

💊 In a cohort of advanced Parkinson's disease, neuropsychiatric adverse events from foslevodopa/foscarbidopa were mild-to-moderate. Except for impulse control disorders, baseline cognitive impairment or prior hallucinations did not increase the risk of new psychotic events.

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European Journal of Neurology @europeanjournalofneurology.ean.org · 22/08/2026

🧩 A new systematic review highlights that targeted neuropsychological tests focusing on visuoperceptual and attentional domains can successfully differentiate prodromal DLB from Alzheimer's disease and healthy aging. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #LewyBodyDementia

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European Journal of Neurology @europeanjournalofneurology.ean.org · 20/08/2026

🔬 Novel diffusion MRI shows that the neurite density index (NDI) of corticospinal subfibers, especially combined with serum NfL, effectively identifies upper motor neuron degeneration in prediagnostic ALS. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #ALS #Neuroimaging

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European Journal of Neurology @europeanjournalofneurology.ean.org · 18/08/2026

🩸 Exploring blood biomarkers for genetic FTD: A multiplex CNS panel reveals distinct plasma proteomic signatures, identifying unique alterations like elevated GFAP and VCAM1 in GRN-FTD, and reduced NPTXR in C9orf72-FTD. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 16/08/2026

📉 Do systemic inflammatory markers predict the efficacy of anti-CGRP therapies? A large real-world study shows that baseline serum hs-CRP and TNF-α levels do not predict treatment response to erenumab in migraine prevention. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Migraine

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European Journal of Neurology @europeanjournalofneurology.ean.org · 14/08/2026

🌐 Open science is key to tackling neurodegenerative diseases. This review outlines the current barriers to sharing brain imaging data and advocates for unified legal frameworks and a new academic credit system to reward data stewardship 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 12/08/2026

💊 In an open-label trial of cenobamate, patients taking fewer concomitant antiseizure medications experienced significantly fewer, milder, and faster-resolving adverse events, underscoring the benefits of treatment simplification. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 31/07/2026

Check out the July issue of European Journal of Neurology! 📚 Read now: onlinelibrary.wiley.com/toc/14681331... #EurJNeurol #Neurology #EJoN @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 29/07/2026

🔄 Switching to ocrelizumab provides durable, long-term disease control in early relapsing multiple sclerosis with suboptimal response to previous therapies. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #MultipleSclerosis #MS

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European Journal of Neurology @europeanjournalofneurology.ean.org · 27/07/2026

🧬 Vutrisiran and patisiran demonstrate superior efficacy over older pharmacological interventions in improving neuropathy impairment and QoL in ATTRv-PN, although these findings should be regarded as hypothesis-generating 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Amyloidosis

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European Journal of Neurology @europeanjournalofneurology.ean.org · 25/07/2026

🧪 Electrochemical skin conductance (ESC) serves as a sensitive, noninvasive biomarker for disease progression and survival in multiple system atrophy (MSA). 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #MultipleSystemAtrophy #MovementDisorders #Biomarkers #Autonomic #Neurology

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European Journal of Neurology @europeanjournalofneurology.ean.org · 23/07/2026

⚡ Noninvasive neuromodulation shows promising efficacy for migraine and cluster headache management. However, a systematic review reveals substantial variability in study designs and inconsistent adherence to guidelines. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 21/07/2026

🚶 Lesion network mapping reveals that post-stroke falls are driven by disruptions in cortical networks supporting voluntary motor control and whole-body coordination, rather than subcortical gait-modulating structures. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Stroke

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European Journal of Neurology @europeanjournalofneurology.ean.org · 18/07/2026

🏥 Mechanical thrombectomy in acute ischemic stroke due to cervical artery dissection achieves high recanalization rates and favorable 90-day outcomes, comparable to non-dissection strokes despite more tandem occlusions. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 16/07/2026

⚖️ Both erenumab and onabotulinumtoxinA produce significant, comparable reductions in headache and migraine frequency after 6 months in chronic migraine. Erenumab demonstrated greater improvements in MIDAS, anxiety, and depression scores 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 14/07/2026

🦽 Delaying wheelchair dependence is a critical milestone in #SPMS. Post hoc analysis of the Phase 3 EXPAND trial reveals that siponimod reduces the risk of reaching sustained EDSS ≥ 7.0 by 40% overall, and by 51% in active SPMS. 📚 onlinelibrary.wiley.com/doi/10.1111/... @EANeurology @WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 11/07/2026

⚠️ Falls are prevalent and disabling in motor #FND, affecting 62% of patients. Absent plantar sensation, greater pain severity and anxiety independently predict recurrent falls, highlighting the need for multidimensional rehabilitation. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 30/06/2026

Check out the June issue of European Journal of Neurology! 📚 Read now: onlinelibrary.wiley.com/toc/14681331... #EurJNeurol #Neurology #EJoN @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 27/06/2026

🏃 A new study reveals that very high physical activity increases the risk of cryptogenic ischemic stroke in young adults. Notably, for patients without a high-risk PFO, very low activity is also a risk factor. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Stroke

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European Journal of Neurology @europeanjournalofneurology.ean.org · 25/06/2026

🧪 Plasma p-tau217 serves as a robust biomarker for Alzheimer's disease in Chinese elderly populations, with strong longitudinal correlation with amyloid pathology and cognitive decline. 📚 Read the recently published article now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 23/06/2026

Pain is a frequent and highly disabling symptom in Functional Motor Disorders (FMD) that correlates with anxiety, depression, fatigue, and significantly reduced quality of life. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #FunctionalNeurologicalDisorder #FMD #Pain

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European Journal of Neurology @europeanjournalofneurology.ean.org · 20/06/2026

Prehospital blood pressure and its difference from hospital-arrival blood pressure show time-dependent associations with in-hospital outcomes in acute spontaneous intracerebral hemorrhage. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #Stroke #IntracerebralHemorrhage

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European Journal of Neurology @europeanjournalofneurology.ean.org · 18/06/2026

A systematic review and meta-analysis confirms that qualitative and quantitative MRI features of plexus imaging as valuable supportive markers for diagnosing CIDP. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #CIDP #Neuroimaging #MRI #Neuropathy #Neurology

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European Journal of Neurology @europeanjournalofneurology.ean.org · 16/06/2026

🧪 CSF Aβ40 and Aβ42 provide complementary diagnostic value for identifying Cerebral Amyloid Angiopathy, both in isolation and with Alzheimer's disease co-pathology. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #CerebralAmyloidAngiopathy #AlzheimersDisease

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European Journal of Neurology @europeanjournalofneurology.ean.org · 13/06/2026

💻 An explainable deep learning model trained on baseline MRI and clinical data can predict long-term neurocognitive disorder progression and cognitive worsening in patients with Multiple Sclerosis. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #MultipleSclerosis

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European Journal of Neurology @europeanjournalofneurology.ean.org · 11/06/2026

Pregnancy-associated PRES and RCVS can result in hemorrhagic stroke. PRES ± RCVS is strongly associated with preeclampsia with severe features, whereas puerperal RCVS seems to be a separate condition. 📚 onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #PRES #RCVS #Stroke #Pregnancy

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European Journal of Neurology @europeanjournalofneurology.ean.org · 09/06/2026

📉 Men with Multiple Sclerosis (MS) experience a lower income trajectory compared to controls at an earlier age than women with MS, with the gap increasing throughout their entire working age. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #MultipleSclerosis #Neurology

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European Journal of Neurology @europeanjournalofneurology.ean.org · 30/05/2026

Check out the May issue of European Journal of Neurology! 📚 Read now: onlinelibrary.wiley.com/toc/14681331... #EurJNeurol #Neurology #EJoN @ean.org #WileyNeuro

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European Journal of Neurology @europeanjournalofneurology.ean.org · 27/05/2026

Digital tools may improve chronic rare brain disorder care when they are embedded into patient pathways, support education, and strengthen communication between patients, caregivers, and clinicians. 📚 Read now: onlinelibrary.wiley.com/doi/10.1111/... @ean.org #WileyNeuro #DigitalHealth

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