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Eunhee Choi

@eunheechoilab.bsky.social

100 followers 152 following 13 posts

Cell biologist with an interest in insulin/IGF signaling and cell division. Assistant professor @Columbia University

Posts Replies Media

Eunhee Choi @eunheechoilab.bsky.social · 30/10/2025

Thank you, Neel!

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Eunhee Choi @eunheechoilab.bsky.social · 30/10/2025

Collaboration with John Wad (Melbourne), Marc Tatar (Brown), & Xiaochen Bai (UTSW). Congratulations Michelle and Kai!

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Eunhee Choi @eunheechoilab.bsky.social · 30/10/2025

We discovered that different insulin-like peptides induce distinct active conformations of the same receptor, tuning signaling strength and physiological outcomes. Nature’s clever design — many signals, one receptor. 🌿

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Eunhee Choi @eunheechoilab.bsky.social · 30/10/2025

Humans have three IR-family receptors (IR, IGF1R, and IRR) — structurally similar, yet functionally distinct. Flies, however, have just one receptor activated by multiple insulin-like peptides, making them a powerful system to decode how ligand diversity drives receptor function.

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Eunhee Choi @eunheechoilab.bsky.social · 30/10/2025

Excited to share our new publication in Nature Communications! 🧬 We explored how evolution shaped the structure–function relationship of the insulin receptor (IR) family using a simplified model — the fruit fly. 🪰 rdcu.be/eM7zG

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Eunhee Choi @eunheechoilab.bsky.social · 30/10/2025

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Eunhee Choi @eunheechoilab.bsky.social · 14/10/2025

Proud collaboration with the Baker Lab (UW) and Bai Lab (UTSW). #ProteinDesign #InsulinReceptor #MolecularCell #BiasedAgonism #TranslationalScience

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Eunhee Choi @eunheechoilab.bsky.social · 14/10/2025

Mechanistically, these ligands reveal how different IR conformations drive distinct signaling outcomes — offering both mechanistic insight and potential therapies for diabetes, cancer, and severe insulin resistance syndromes.

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Eunhee Choi @eunheechoilab.bsky.social · 14/10/2025

⚙️ Balanced agonists mimic insulin’s full activity on metabolism and growth. ⚖️ Partial/biased agonists activate only the metabolic branch, without triggering receptor endocytosis or proliferation. 🚫 Antagonists block insulin-dependent activation.

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Eunhee Choi @eunheechoilab.bsky.social · 14/10/2025

🎉 Excited to share our new paper just published in Molecular Cell! Using computational protein design, we developed de novo ligands that induce distinct active conformations of the insulin receptor (IR). 🔗 Read the paper: authors.elsevier.com/sd/article/S...

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Eunhee Choi @eunheechoilab.bsky.social · 14/10/2025

Using computational protein design, we developed de novo ligands that induce distinct active conformations of the insulin receptor (IR) — including balanced agonists, partial/biased agonists, and antagonists.

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Eunhee Choi @eunheechoilab.bsky.social · 11/02/2025

Thank you for your great comments for this Review!

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Eunhee Choi @eunheechoilab.bsky.social · 10/02/2025

Excited to share our recent review on the insulin-IGF receptor signaling!

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