iiinova — where your digital self keeps evolving

Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 18/09/2026

Super excited for this new chapter in London! Life is great, science is great, no notes.

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 03/09/2025

Inspired by the all the amazing science at the Argonaute meeting, I painted an argonaut!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 01/09/2025

Haven’t got enough of Argonaute in the past few days. Found more in the National Museum in Prague. It was such a great meeting!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 26/08/2025

So excited for all the fun science in the next 4 days!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 23/08/2025

Sciece is my profession but also my hobby. Another hobby of mine is watercolor and I’ve been thinking I should share more that here. Painting has big influence on how I do science and vice versa. More on this later 🎨🧬🔬🥼

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 11/08/2025

In any case, the surviving progeny in ne299 is very small (~10) after one generation at 25C (upshift at L2 stage), nearly 0 when I scored only day 2 adults. pmc.ncbi.nlm.nih.gov/articles/PMC...

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 11/08/2025

We found that introducing the ancestral alleles of these genes back into N2 partially rescues rde-4 fertility defects at high temperature, suggesting that small RNAs buffer the deleterious effects of lab domestication! The domesticated alleles boost fitness in comfy lab but reduce stress tolerance.

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 11/08/2025

Here, We found that rde-4 mutants have severe, temperature-sensitive defects in both sperm and oocyte development. Rescuing RDE-4 ONLY IN THE NEURONS partially restored fertility! Most surprisingly, we could rescue the sterility in rde-4 mutants by blocking the O2-sensing neurons!🧠->🥚

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 24/03/2025

First piece result from my clay class:

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 08/03/2025

😂 very standard technique in C. elegans lab. It gives much control and precision (discretion advised)

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/01/2025

I made a thing in my art class today! 🪱🔬 #celegans #worm

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 02/01/2025

Tried my first art class yesterday. My teacher said that I have a double life - science by day, painting by night. But I thought, in many ways, they aren’t all that different: in both, we reveal the light by creating contrast (ruling out alternative explanations). Loved every moment of it!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/12/2024

10/12 Finally, we found that pals-22 regulates the expression of germline Argonuates, affecting germline mortality upon heat stress typically linked to defective epigenetic inheritance.

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/12/2024

9/12 Interestingly, removing both pals-22 and endo-siRNA causes DOWNregulation of immune genes, suggesting a non-canonical role of siRNAs in promoting gene expression in the absence of pals-22!!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/12/2024

8/12 When we removed pals-22 alone, immune genes are massively upregulated. Similarly, removing components of the endogenous siRNA pathway, immune genes are upregulated, indicating that immune genes are normally targeted by RNAi.

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/12/2024

7/12 we also found that removing the mysterious argonaute VSRA-1, which had no clear function, rescues pals-22(-) silencing phenotype AND interestingly, loss of pals-22 causes HUGE upregulation of vsra-1, changing its activity and tissue specificity!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/12/2024

6/12 Let’s take a few steps back…First, we found that PALS-22 suppresses the antiviral RNAi pathway that involves DRH-1 (RIG-I homolog in worm)! Removing drh-1 or RdRP rescues pals-22’s silencing phenotype.

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 06/12/2024

4/12 One of the members, PALS-22, has been found to be a potent suppressor of the transcriptional response against intracellular pathogens (namely virus and microsporidia) but the loss of pals-22 also causes downregulation of transgenes - hinting at a role in RNAi-mediated gene silencing!

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Ethan (Chee Kiang) Ewe @ethanewe.bsky.social · 24/11/2024

Post a non-religious photo you think of as holy

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