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Epilepsia Open @epilepsia-open.bsky.social · 16/01/2026

Research priorities in epilepsy: a consensus position paper from the European Reference Network ERN EpiCARE. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #Epilepsy #ERN #EpiCARE #EU4Health #HealthUnion #genetics #rareandcomplexepilepsies #researchfunding @stephane_auvin

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Epilepsia Open @epilepsia-open.bsky.social · 15/01/2026

Patients receiving PER MT were more likely to achieve seizure freedom but had a higher incidence of dizziness than those receiving LEV MT. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #Chinesepatients #focalonsetseizures #Levetiracetam #Perampanel #monotherapy #seizurefreedomrate

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Epilepsia Open @epilepsia-open.bsky.social · 12/01/2026

This case shows the potential of SqEEG to guide treatment decisions in the perioperative setting. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #epilepsysurgery #epilepsytreatment #objectiveseizuredocumentation #subcutaneousEEG #ultralongtermEEGmonitoring

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Epilepsia Open @epilepsia-open.bsky.social · 15/12/2025

URE patients had a median of six failed treatment strategies, including surgery or neurostimulation. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #antiseizuremedication #drugresistantepilepsy #neurostimulation #resectivebrainsurgery #ultrarefractoryepilepsy

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Epilepsia Open @epilepsia-open.bsky.social · 12/12/2025

In the cavernous sinus, eEEG detected IEDs with higher amplitude than scalp EEG, indicating its diagnostic potential. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #EP01 #focalonsetepilepsy #localizedepileptogenicity

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Epilepsia Open @epilepsia-open.bsky.social · 12/12/2025

Introducing a systematic sample handling protocol to assess tissue epileptogenicity at structural, functional and molecular levels. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #electronmicroscopy #electrophysiology #histology #MRI #multiscale #omics

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Epilepsia Open @epilepsia-open.bsky.social · 11/12/2025

The overall pooled prevalence of active cases of IESS was 3.33 per 100 000 population (95% CI, 1.46–5.82) in India. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #burden #infantilespasms #prevalence

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Epilepsia Open @epilepsia-open.bsky.social · 10/12/2025

Dravet Syndrome is now diagnosed earlier but this has not led to earlier initiation of stiripentol treatment.⁠ doi.org/10.1002/epi4... ⁠ #epilepsy #ILAE #epilepsiaopen #efficacy #healthcareutilization #qualityoflife #statusepilepticus #stiripentol #DravetSyndrome⁠

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Epilepsia Open @epilepsia-open.bsky.social · 09/12/2025

The ELUCID Study is a prospective, multi-site, longitudinal observational study on late-onset unexplained epilepsy (LoUE). doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #cognition #dementia #elderly #lateonset

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Epilepsia Open @epilepsia-open.bsky.social · 08/12/2025

New in Epilepsia Open – December 7, 2025 mailchi.mp/ilae/epileps... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Open @epilepsia-open.bsky.social · 04/12/2025

Martinique status epilepticus incidence: 25.2/100000—ourfold higher than mainland France. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #mobileintensivecareunit #mortality #prehospitalcare #statusepilepticus #WestIndies

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Epilepsia Open @epilepsia-open.bsky.social · 21/11/2025

We performed epilepsy surgery in experimental models of focal onset seizures to investigate the effectiveness of surgeries using neurophysiological and metabolic changes before and after the surgery. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #DBS #kainicacid #kindling

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Epilepsia Open @epilepsia-open.bsky.social · 21/11/2025

RNS with neocortical depth leads achieved 66.7% seizure reduction at 1 year and 77.5% at long term follow up. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #depthelectrode #neocortex #networkremodeling #responsiveneurostimulation #RNS #seizure #sEEG

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Epilepsia Open @epilepsia-open.bsky.social · 20/11/2025

This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel

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Epilepsia Open @epilepsia-open.bsky.social · 19/11/2025

Epilepsy is associated with significantly increased long-term risk of cardiovascular disease. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #cardiovasculardiseases #riskfactors #SouthKorea

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Epilepsia Open @epilepsia-open.bsky.social · 17/11/2025

This is a pediatric case series of patients suffering from multifocal or generalized drug-resistant epilepsy treated with centromedian RNS. doi.org/10.1002/epi4... #epilepsy #ilae #epilepsiaopen #centromediannucleus #thalamus #drugresistantepilepsy #pediatric #responsiveneurostimulation

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Epilepsia Open @epilepsia-open.bsky.social · 17/11/2025

We compared the early adjuvant treatment outcomes of IV lacosamide and levetiracetam for status epilepticus after benzodiazepine use. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #antiseizuremedication #diagnosisprocedurecombination #overlapweighting #propensityscore #seizure

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Epilepsia Open @epilepsia-open.bsky.social · 13/11/2025

Combined multimodal imaging (82–100% sensitivity) outperforms single modalities for localizing epileptogenic foci in surgical candidates. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #multimodalimaging #neuroimaging #radiosurgery #stereotactic

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Epilepsia Open @epilepsia-open.bsky.social · 12/11/2025

The study compared the effectiveness of 5 mg melatonin versus partial sleep deprivation in inducing sleep during nap-time EEG in children with epilepsy. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #melatonin #napEEG #sleepinduction #sleeplatency

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Epilepsia Open @epilepsia-open.bsky.social · 11/11/2025

This review provides a practical approach to assessing and selecting PROMs, and discusses how they may be incorporated into clinic workflows. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #mooddisorders #patientreportedoutcome #qualityoflife #seizure

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Epilepsia Open @epilepsia-open.bsky.social · 10/11/2025

New in Epilepsia Open – November 9, 2025 mailchi.mp/ilae/epileps... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Open @epilepsia-open.bsky.social · 07/11/2025

Global adolescent epilepsy burden increased 1990–2021, with marked regional and SDI disparities. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #adolescenthealth #globalburdenofdisease #healthpolicy #publichealth

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Epilepsia Open @epilepsia-open.bsky.social · 07/11/2025

Approximately, 26% patients with unexplained seizures or epilepsy deterioration tested positive for autoimmune or paraneoplastic antibodies. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #antibodytesting #APEscore #autoimmuneencephalitis #EEG #paraneoplasticencephalitis

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Epilepsia Open @epilepsia-open.bsky.social · 06/11/2025

After a median follow-up of 20 months, CBD was globally effective and safe in 107 patients with LGS, DS, TSC, and other DEEs. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #CBD #DEE #Dravetsyndrome #LennoxGastautsyndrome #realworld #cannabidiol

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Epilepsia Open @epilepsia-open.bsky.social · 05/11/2025

This MR study assessed causal links between thousands of plasma proteins and epilepsy risk. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #causalinference #GWAS #MR #plasmaproteins

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Epilepsia Open @epilepsia-open.bsky.social · 04/11/2025

The preponderance of evidence indicates that the KD is effective in targeting IESS. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #acidosis #infantileepilepticspasms #ketogenicdiet #microbiome #tryptophan

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Epilepsia Open @epilepsia-open.bsky.social · 03/11/2025

Serum phosphate measurements are rarely included in the acute evaluation of Transient Loss of Consciousness (TLoC). doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #biomarker #electrolyte #hypophosphatemia #seizure #telemedicine

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Epilepsia Open @epilepsia-open.bsky.social · 28/10/2025

Letter and Response - Addressing "SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications" Letter: doi.org/10.1002/epi4... Authors’ Response: doi.org/10.1002/epi4... Original Article: doi.org/10.1002/epi4... #Epilepsiaopen #Epilepsy #ILAE

doi.org

To the editors: SCN1A gain‐of‐function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications

Click on the article title to read more.

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Epilepsia Open @epilepsia-open.bsky.social · 27/10/2025

New in Epilepsia Open – October 26, 2025 mailchi.mp/ilae/epileps... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Open @epilepsia-open.bsky.social · 27/10/2025

The degree and frequency of language decline reported in research literature are influenced by the protocols used to assess language functions. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #confrontationnaming #languageoutcomes #reliablechange #temporallobeepilepsy #verbalfluency

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Epilepsia Open @epilepsia-open.bsky.social · 23/10/2025

69.8% of epilepsy patients preferred in-person care despite high digital literacy and environmental concern. doi.org/10.1002/epi4... #epilepsy #ilae #epilepsiaopen #climatechange #telemedicine #digitalliteracy #enviromentalawareness

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Epilepsia Open @epilepsia-open.bsky.social · 22/10/2025

Progressive clonic slowing is associated with marked oxygen desaturation during bilateral tonic–clonic seizures. doi.org/10.1002/epi4... #epilepsy #ilae #epilepsiaopen #SUDEP #Progressiveclonicslowing #PostictalImmobility #Tonicclonicseizure #Respiratorydysfunction

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Epilepsia Open @epilepsia-open.bsky.social · 21/10/2025

The multiple-hit rat model is a model of structural etiology drug-resistant infantile epileptic spasms syndrome (IESS). doi.org/10.1002/epi4... #epilepsy #ilae #epilepsiaopen #Sivelestat #fingolimod #methylprednisolone #topiramate #insulingrowthfactor

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Epilepsia Open @epilepsia-open.bsky.social · 20/10/2025

To target seizure freedom, physicians should aim to optimize treatment, minimize delays, and improve medication adherence. doi.org/10.1002/epi4... #epilepsy #epilepsiaopen #ILAE #antiseizuremedications #inflammation #qualityoflife #seizure

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Epilepsia Open @epilepsia-open.bsky.social · 17/10/2025

Although most became eligible to drive after VNS implantation without significant medication changes, some required additional medication changes to achieve seizure control. doi.org/10.1002/epi4... #epilepsy #epilepsiaopen #ILAE #driving #drugresistantepilepsy #vagusnervestimulation #VNS

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Epilepsia Open @epilepsia-open.bsky.social · 17/10/2025

We present the largest series reporting on the off-label use of Cenobamate (CNB) in 16 adults with drug-resistant idiopathic generalized epilepsy, including 12 with JME. onlinelibrary.wiley.com/doi/10.1002/... #epilepsy #ilae #epilepsiaopen #antiseizuremedication #Cenobamate #healthcareutilization

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Epilepsia Open @epilepsia-open.bsky.social · 16/10/2025

Norwegian respondents prescribed buccal midazolam at higher doses and amidst a greater range of comorbidities than UK respondents. onlinelibrary.wiley.com/doi/10.1002/... #epilepsy #ilae #epilepsiaOpen #benzodiazepine #epilepsymortality #epilepsyrisk#rescuetherapy

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Epilepsia Open @epilepsia-open.bsky.social · 15/10/2025

Late-onset epilepsy of unknown etiology (LOEU) is less likely to receive ASM polytherapy than acquired lesional late-onset epilepsy (LOE). doi.org/10.1002/epi4... #epilepsy #ilae #epilepsiaOpen #Alzheimersdisease #cerebrovasculardisease #elderly #lateonsetepilepsy #neurodegenerativedisease

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Epilepsia Open @epilepsia-open.bsky.social · 13/10/2025

New in Epilepsia Open – October 12, 2025 mailchi.mp/ilae/epileps... Subscribe - eepurl.com/iLSrNc #epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

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Epilepsia Open @epilepsia-open.bsky.social · 10/10/2025

Two patients had both Lafora disease and distinct rare neurodevelopmental disorders related to pathogenic variants in TRIO and SHANK3. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #nextgenerationsequencing #NGS #PhelanMcDermidsyndrome #myoclonusepilepsy #WES #wholegenomesequencing #WGS

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Epilepsia Open @epilepsia-open.bsky.social · 10/10/2025

Limited data exist on managing pregnancy in Women with Epilepsy (WwE) in rural areas of LMICs. doi.org/10.1002/epi4... #epilepsy #ILAE #Epilepsiaopen #antiseizuremedications #preconception #pregnancy

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Epilepsia Open @epilepsia-open.bsky.social · 09/10/2025

Real-world data are lacking on nonseizure symptom impacts on patients with Dravet (DS) and Lennox–Gastaut syndromes (LGS) and caregivers. doi.org/10.1002/epi4... #epilepsy #ILAE #Epilepsiaopen #caregiver #diseaseburden #Dravetsyndrome #LennoxGastautsyndrome #nonseizuresymptoms

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Epilepsia Open @epilepsia-open.bsky.social · 08/10/2025

PGES occurred in 52% of patients with focal or generalized epilepsy after GTCS. doi.org/10.1002/epi4... #epilepsy #ILAE #Epilepsiaopen #corticalsubcorticalparcellation epilepsy #GTCS #PGES #thalamus

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Epilepsia Open @epilepsia-open.bsky.social · 07/10/2025

Most respondents consider surgery in Lennox–Gastaut Syndrome (LGS) after failure of 3–4 medications and ketogenic diet, later than ILAE-recommended guidelines. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #epilepsysurgery #LennoxGastautsyndrome #neuromodulation #surgicaldecisionmaking

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Epilepsia Open @epilepsia-open.bsky.social · 06/10/2025

SE consists of prolonged seizures that can cause hippocampal injury and respiratory compromise. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #benzodiazepines #AMPAreceptors #GABAAreceptors #NMDAreceptors #receptortrafficking

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Epilepsia Open @epilepsia-open.bsky.social · 03/10/2025

Knowledge about epilepsy is still low among adults in Sudan. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #beliefs #misconceptions #practices #Sudan

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Epilepsia Open @epilepsia-open.bsky.social · 03/10/2025

PMX53 and ACTH analogs show promise; personalized treatments may depend on IESS subtype and sex of the patient. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #ACTH #EEG #estradiol #hypothalamus #IESS

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Epilepsia Open @epilepsia-open.bsky.social · 02/10/2025

Findings underscore the need to better characterize and support patients with diagnostically ambiguous seizure events. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #costofillness #healthservicesresearch #healthcareaccess #healthcaredisparities

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Epilepsia Open @epilepsia-open.bsky.social · 01/10/2025

A total of 70.3% of patients were seizure-free after 12 months on perampanel monotherapy. doi.org/10.1002/epi4... #epilepsy #ILAE #epilepsiaopen #monotherapy #perampanel

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