Tu et al. present a systematic analysis of the tumor microenvironment across 14,837 breast cancers, identifying distinct cellular patterns that predict disease-specific survival independently of genom...

This study develops a semi-supervised classifier integrating multi-genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer....

In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.