iiinova — where your digital self keeps evolving

Reposted by Elsie Place

Seth Blackshaw @sethblackshaw.bsky.social · 11/01/2025

We begin the New Year with two preprints on hypothalamic development. The first, part of a long-term collaboration with Marysia Placzek’s group, investigates the organization of the developing forebrain, and show that current models are (mostly) incorrect./1 www.biorxiv.org/content/10.1...

biorxiv.org

Resolving forebrain developmental organisation by analysis of differential growth patterns

The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...

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Reposted by Elsie Place

Seth Blackshaw @sethblackshaw.bsky.social · 12/01/2025

Our second preprint, which was spearheaded by @thomasdwkim.bsky.social, uses single-cell multiomic analysis to identify gene regulatory networks controlling neurogenesis and cell fate specification in mouse hypothalamus and prethalamus./1 biorxiv.org/cgi/content/...

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Reposted by Elsie Place

Elizabeth Manning @emmanning.bsky.social · 13/01/2025

Brought to life through the magic of Blender... For more details and more movies go to our preprint www.biorxiv.org/content/10.1...

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Elsie Place @elsieplace.bsky.social · 13/01/2025

Excited to present our new preprint clarifying forebrain developmental organisation. Complex growth patterns shape the forebrain but distort the A-P + D-V axes, hence prior confusion over brain layout. Big love for chicken embryos, simpler to interpret than mouse 🐣1/3 www.biorxiv.org/content/10.1...

biorxiv.org

Resolving forebrain developmental organisation by analysis of differential growth patterns

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