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Tracking luminescent reporter light intensity is a fast, easy way to quantify population decline at high concentrations and tends to be a better proxy for biomass than for cell number.

Contrary to previous belief, the cyanobacterium Synechocystis lacks the Entner-Doudoroff pathway for glucose metabolism.

Age-specific templates improve the quality of functional alignment using hyperalignment algorithms, and the improvement is consistent across age groups, validation analyses, and datasets.

Modeling the metabolic microenvironment of pancreatic tumors leads to the identification of polyunsaturated fatty acid metabolism as a vulnerability of pancreatic cancer.

Modeling the metabolic microenvironment of pancreatic tumors leads to the identification of polyunsaturated fatty acid metabolism as a vulnerability of pancreatic cancer.

Cooperation between individual virions of human cytomegalovirus at infecting cells leads to nonlinear scaling of cell infection probability with virion concentration.

Parallelized, cloud-compatible pipelines reduce spike sorting of large-scale neural recordings from weeks to hours, and enable systematic benchmarking of algorithms on hybrid data.

Probiotic communities designed to inhibit a lung pathogen through niche exclusion show promise as a novel method of preventing respiratory infection.

Prolonged oxycodone abstinence strengthens paraventricular thalamus to nucleus accumbens shell glutamatergic transmission in both sexes, yet only females show enhanced relapse, dissociating shared synaptic...

In-situ glial cell-surface proteomics reveals DIP-β as a glial longevity factor that enhances intercellular communication and extends lifespan in aging Drosophila.

DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.

Heterogeneity in outcomes of differently located activating mutations of Notch indicates the need and potential for mutant specific targeting of Notch in cancer.

DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.

Face-selective neural activity occurs concurrently across the human ventral occipito-temporal cortex, challenging traditional hierarchical models of visual object recognition where response latencies...

Leiomodin 1 acts as a critical molecular switch during early muscle stem cell differentiation by sequestering the deacetylase SIRT1 in the cytoplasm to initiate the myogenic program.

Genetic influences on how the brain processes complex naturalistic stimuli can be traced back to inherited control over stable spatial and temporal features of brain function.

Genetic deletions in mouse models and human neuron co-cultures reveal that astrocytic neuroligins are dispensable for synapse formation and maintenance of normal astrocyte morphology, suggesting neuroligins...

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Synesthetes' pupils reflect the brightness of colors that they only see internally, making their hidden perceptual experience objectively measurable.

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Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.

Repurposed drugs show promise as a faster treatment for snakebites in Latin America

Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.

Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.

Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.

Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.

A novel computational pipeline reveals patterns of tissue movement and growth in early heart formation and advances virtual modeling of development.

A novel computational pipeline reveals patterns of tissue movement and growth in early heart formation and advances virtual modeling of development.

Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as...

Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as...

Leveraging the smooth variation of internal noise makes comprehensive characterization of color discrimination practical, offering an efficient framework for studying perceptual limits across various...

Combining intracranial recordings with no-report paradigms and computational models offers the clearest path yet to isolating genuine neural correlates of consciousness from their prerequisites and consequences.

Titin-associated muscle ankyrin repeat proteins limit stretch-induced longitudinal muscle hypertrophy and link titin mechanosensing to mTOR signaling.

Titin-associated muscle ankyrin repeat proteins limit stretch-induced longitudinal muscle hypertrophy and link titin mechanosensing to mTOR signaling.

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eLife publishes research on the mechanisms and biological significance of environmentally driven epigenetic inheritance.

Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered...

Our author explainer videos allow you to illustrate your research and figures, bringing them to life, but what makes a good explainer video? Read our top tips.

Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered...

A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.

A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.