Reflecting on the publications in PLOS One in 2025, the diversity and quality of the work is demonstrated in articles ranging from…

Psychedelics can cause long-lasting challenging experiences. In certain settings, they can be transformative

During or after intense psychedelic experiences – typically elicited by taking a high dose, or a synergistic drug combination – one may find oneself in a state known as ontological shock. This is when...

Psychedelic induced mystical experiences have been largely assumed to drive the therapeutic effects of these substances, which may in part be mediated by changes in metaphysical beliefs. However, ther...

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Psychedelic substances are increasingly recognized for their potential to catalyse transformative shifts in worldviews. Central to these transformations are states of awe, a self-transcendent, epistem...