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Early-life Immune Network Europe

@efis-eline.bsky.social
51 followers 63 following 33 posts

EFIS study group on early-life immune development. We will announce our seminar series here and update you on recent literature. Website: www.efis-eline.eu/home

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Early-life Immune Network Europe @efis-eline.bsky.social · 25/06/2026
Excited for our seminar next week - July 2, 4 pm CEST - with two fantastic early life speakers and topics: 🎤 Muzlifah Haniffa - Decoding the tissue ecosystems of the human body 🎤Evita Lou - Searching for immunomodulatory metabolites in early life Register here: www.efis-eline.eu/seminars
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Early-life Immune Network Europe @efis-eline.bsky.social · 08/06/2026
Interesting review on early life immune development: www.nature.com/articles/s41...
nature.com
Immune development in early life - Nature Immunology
Palma et al. discuss the current state of the field on early immune development in humans.
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Early-life Immune Network Europe @efis-eline.bsky.social · 04/06/2026
Looking forward to our seminar today, 4 pm CEST! Join us and register here: www.efis-eline.eu/seminars
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Early-life Immune Network Europe @efis-eline.bsky.social · 26/05/2026
In our next seminar on June 4, 4 pm CEST, we focus on B cells with 2 fantastic speakers: 🎤Joan Yuan - Mapping the early-life imprinting of adult B cells 🎤Reem Naamneh - Shaping Early-Life Oral Immunity: Uncovering a Novel Role for Maternal Antibodies Register here: www.efis-eline.eu/seminars
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Early-life Immune Network Europe @efis-eline.bsky.social · 30/04/2026
#EarlyLifeImmunity #Immunology #EFIS #ELINE
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Early-life Immune Network Europe @efis-eline.bsky.social · 30/04/2026
One week until our next seminar, Thursday, May 7, 4 pm CET🤩 Register here: www.efis-eline.eu/seminars
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Early-life Immune Network Europe @efis-eline.bsky.social · 15/04/2026
#EarlyLifeImmunity #Immunology #EFIS #ELINE
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Early-life Immune Network Europe @efis-eline.bsky.social · 15/04/2026
Looking forward to our next seminar on May 7🎉 🎤Tobias Kollmann - Why do newborns die? What we can do about it: Shift focus from pathogen to host 🎤Clara Delaroque - Microbiome in Heritage: How Maternal Microbiome Transmission Impacts Next-Generation Health Registration: www.efis-eline.eu/seminars
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Early-life Immune Network Europe @efis-eline.bsky.social · 26/03/2026
1 week until our next seminar! 🎉 Register here: www.efis-eline.eu/seminars
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
Hopefully, this will help to push the severe E.coli infection numbers below 1 of 1000 in the future! (7/7) Read the full paper here: www.nature.com/articles/s41...
nature.com
Natural maternal immunity protects neonates from Escherichia coli sepsis - Nature
Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual&nbsp...
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
Levels of E. coli specific IgGs were similar in maternal blood pre birth and cord blood, opening an angle for prenatal screening for babies at potentially high risk of E. coli infections/sepsis as well as potential probiotic use of E. coli during pregnancy to prevent infections (6/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
While total IgG amounts did not differ, E. coli specific IgGs, especially OmpA-specific (highly conserved, abundant outer membrane protein of E.coli and other Gram-negative bacteria) did: Babies who later on developed sepsis had decreased levels of these specific IgGs. (5/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
To show that this is relevant in human neonates as well, dried blood spots from routine neonatal screening were used to investigate the relationship between antibodies and later E. coli infections and sepsis: (4/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
Nissle induced IgG was transfered to the offspring via the placenta, protecting neonatal mice born to Nissle colonized dams from E.coli UTI89 infection. This depended on FcgR and complement system in the pups, showing that the maternal antibodies opsonize pathogenic E. coli (3/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
The authors employed a trait of specific pathogen free mice often seen as a disadvantage - being devoid of commensal E.coli colonization. They colonized female mice with E. coli Nissle. This induced a IgG responses and protected against infection with other E. coli strains via cross-reactivity (2/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 18/03/2026
Nearly every baby is colonized by various E. coli at birth, but luckily only 1 in 1000 develops a severe infection: A new paper in Nature shows how maternal IgG specific to mum`s gut E.coli protects neonates. Read here: www.nature.com/articles/s41... #EFIS #ELINE #NeonatalImmmunology (1/7)
nature.com
Natural maternal immunity protects neonates from Escherichia coli sepsis - Nature
Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual&nbsp...
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Early-life Immune Network Europe @efis-eline.bsky.social · 12/03/2026
Save the date for our second seminar: April 2, 4 pm CET 🎤 Adrian Erlebacher - Mechanisms of parturition timing in mice 🎤 Dan Corral – Maternal Immune Regulation of Lactation Register here: www.efis-eline.eu/seminars #EarlyLifeImmunity #Immunology #EFIS
efis-eline.eu
EFIS-ELINE - Seminars
Seminars run on the first Thursday of every month at 16:00 CET. We kick off with a 15-minute spotlight talk from an early-career researcher, then a senior scientist takes the stage for a deeper dive, ...
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
Link: www.science.org/doi/10.1126/... #ELINE #EarlyLifeImmunity #Vaccines #MucosalImmunology #BCG #TrainedImmunity #Immunology (7/7)
science.org
Mucosal vaccination in mice provides protection from diverse respiratory threats
Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
At ELINE, we are interested in how these principles translate to infants. Understanding the unique organization of the neonatal immune system is essential to determine whether similar immune programs can be induced early in life and how these concepts can be integrated into vaccine strategies. (6/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
At the same time, key questions remain. In particular, we still need to understand how antigen-specific T cells can drive apparently antigen-independent protection, and how such immune circuits are established and maintained. (5/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
Together with work on trained immunity, these findings support a broader view of vaccine action in which adaptive immune memory, innate cell programming, and tissue niches cooperate to generate pathogen-agnostic protection. (4/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
This paper provides an intriguing mechanistic perspective such effects: The authors show that mucosal vaccination can establish lung-resident memory T cells that imprint alveolar macrophages and tissue environment, generating a durable immune state with rapid response to diverse pathogens. (3/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
Some vaccines provide benefits beyond protection against their intended pathogen: BCG vaccination in children showed that BCG scar formation/positive tuberculin response were associated with reduced childhood mortality in general, not only protection from tuberculosis. (2/7)
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/03/2026
Most vaccines are designed to protect against a single pathogen - this new study proposes a different concept: mucosal vaccination providing broad protection against multiple respiratory pathogens. www.science.org/doi/10.1126/... Reminds us of BCG vaccination in neonates! (1/7)
science.org
Mucosal vaccination in mice provides protection from diverse respiratory threats
Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...
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Early-life Immune Network Europe @efis-eline.bsky.social · 01/03/2026
Interestingly, in another setting and model, postnatal skin CD301b+ DC2 have been described as well in Treg induction to skin commensals, with priming happening in the lymph nodes. Further reading here (5/5): pubmed.ncbi.nlm.nih.gov/37028427/
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Early-life Immune Network Europe @efis-eline.bsky.social · 01/03/2026
This adds to the growing evidence that early life immunity is qualitatively different from adult on tissue-specific level - definitely worth a read for everyone thinking about postnatal maturation of tissue immunity and mechanisms or developmental windows of atopic disease/allergy induction (4/5)
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Early-life Immune Network Europe @efis-eline.bsky.social · 01/03/2026
They show that CD301b+ cDC2 in a distinct state - so called “peripheral immune-inducer” DCs - can prime IL17+ gdT cells locally in the skin, without migration to lymph nodes. This process was limited to the first 2 weeks after birth and controlled by corticosterone signalling (3/5)
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Early-life Immune Network Europe @efis-eline.bsky.social · 01/03/2026
When challenging neonatal mice with house-dust mite as well as other common allergen injection to the skin, the authors observed a much more aggravated inflammatory reaction than in adults - why? (2/5)
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Early-life Immune Network Europe @efis-eline.bsky.social · 01/03/2026
New exciting #NeonatalImmunology paper: Peripheral immune-inducer dendritic cells drive early-life allergic inflammation (1/5) www.nature.com/articles/s41...
nature.com
Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature
Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...
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Early-life Immune Network Europe @efis-eline.bsky.social · 26/02/2026
One week until our the kick-off of our seminar series! Stay tuned and register here: www.efis-eline.eu/seminars #EarlyLifeImmunity #Immunology #EFIS
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/02/2026
What do we do? 💡 monthly open online seminar series to foster exchange, visibility, and new collaborations across the community and showcase work of early career researchers and established PIs in neonatal immunology 🌆 Stay tuned for in-person meeting dealing with neonatal immunology!
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/02/2026
What is ELINE? We are a brand new EFIS study group: ELINE stands for Early Life Immunity Network Europe - our goal is to connect researchers and clinicians across Europe working on immunity in the newborn and infant period.
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Early-life Immune Network Europe @efis-eline.bsky.social · 06/02/2026
We are excited to kick-off of our seminar series on March 5, 4pm CET 🥳 🎤 Petter Brodin – A seeding reaction to colonizing microbes in human newborns 🎤 Eva Stange – Neonatal liver niches program T cell tolerance Register here: www.efis-eline.eu/seminars #EarlyLifeImmunity #Immunology #EFIS
efis-eline.eu
EFIS-ELINE - Seminars
Seminars run on the first Thursday of every month at 16:00 CET. We kick off with a 15-minute spotlight talk from an early-career researcher, then a senior scientist takes the stage for a deeper dive, ...
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