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Evan Pepper

@e-pepper.bsky.social
42 followers 70 following 2 posts

PhD Candidate in Molecular Engineering at the University of Washington and the Institute for Systems Biology with the Baliga Lab. Researching evolution of antimicrobial resistance in tuberculosis. #AMR #TB

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Evan Pepper @e-pepper.bsky.social · 18/05/2026
Reposting because I'm still so thrilled to have this work out and open access for anyone to view. Still so much work to do to combat #AMR – identifying the evolutionary mechanisms by which bacterial pathogens acquire drug resistance will prove to be an important step toward this effort!
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Evan Pepper @e-pepper.bsky.social · 07/05/2026
I’m excited to share our research published today with @springernature.com in @natcomms.nature.com! Here, we find that oxidative stress generated by the host immune system can prime tuberculosis to rapidly evolve antibiotic resistance, revealing how resistance may emerge before treatment #TB #AMR
nature.com
Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution - Nature Communications
This study challenges the paradigm that resistance mutations precede fitness compensatory adaptations, showing that pre-existing alterations in mycobacterial oxidative stress responses can prime rapid...
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