How M. Neil Browne and Stuart M. Keeley

Dermatologist and biotech investor Dr. Adam May has unveiled his first pitch in 448 days, targeting Zura Bio ($ZURA) and its dual IL-17A/BAFF bispecific antibody tibulizumab ahead of a pivotal Q4 2026 Phase 2 Hidradenitis Suppurativa readout. We conduct an exhaustive forensic cross-examination: audi

CoreWeave

Following Dr. Adam May

Over the weekend of October 11–12, 2026, CXMT President Dr. Cao Kanyu claimed China’s memory champion achieved a 4F² DRAM breakthrough using Vertical Surrounding Gate (VSG) transistors, targeting server DDR5 RDIMMs by year-end. This announcement triggered a 7% plunge in Samsung and SK Hynix shares.

Andrej Karpathy

149 stories clear 200 points and only 26 of them are new. The day

Bristol Myers Squibb claimed victory in its Phase 3 ALOFT-IPF trial for admilparant at 60 mg, but buried a critical failure: the higher 120 mg dose was not statistically significant, and actual mL effect sizes were withheld. We conduct a deep forensic audit into non-monotonic dose response, LPA1 rec

A comprehensive forensic deep dive into 50 years of biopharmaceutical clinical trial failure rates across Phase 1, Phase 2, Phase 3, and regulatory approval. We examine foundational data from Tufts CSDD, Nature, BIO, MIT, and IQVIA to answer whether trials fail more today than in the 1970s, the mech

Only 25 new stories clear 200 points out of 130 on the ranked list — and half of what moved was legal: Nitter loses its lawyers, Exxon loses the argument, and Yandex loses a third data center.

The US sanctions the ICC the day after it honors an ICC judge, Triple-A Minesweeper explains what

In 2021, the world was told mRNA was a software compiler that would cure all diseases overnight. By 2025, pipelines were slashed and billions evaporated. As Novartis commits $7.8B to in vivo mRNA in late 2026, here is the unvarnished reality check on what failed, what survived, and where the science

Cloudflare absorbs Deno, DeepSeek

A comprehensive, chapter-by-chapter synthesis of Browne and Keeley

Margaret Hamilton dies at 90, OpenAI

OpenAI publishes AI-generated math proofs with Lean formalizations, Meta

Fourteen of the thirty front-page stories hold 200 points, while the full rank list holds 124 — and the day

A hundred and one stories hold 200+ points inside the top 500 ranks, seventeen of them new. The week

A hundred and thirty-three stories hold 200+ points inside the top 500 ranks, twenty-seven of them new. The week

The page unfroze: fifty-five stories cleared 200 points, eleven of them new. Aleph Alpha shipped a 78B German sovereign model under Apache 2.0, Meta open-sourced the firmware for its agent and kept the token, Apple admitted Full Disk Access is a hole and blamed AI agents for making it worse.

The front page ceiling was 305 points and only two stories cleared the 200-point bar on the page itself: a federal court told Utah that VPN detection is not a thing, and a 1973 essay about von Neumann took second place. The day

I

Forty-two stories cleared 200 points and seventeen are new. Someone built an instrument to prove whether Opus 5.5 got quietly worse, the White House shipped a chatbot that talks to 29,000 government websites, and a Polish essay makes the case that the last thirty years were one long trade of buffers

Forty-one stories cleared 200 points and twenty-four are new. OpenAI launched a cheaper model at DevDay and quietly did not launch a smarter one, Google finally published satellite imagery it had been sitting on, and a self-reported astroturfing study found 11 percent.

Forty-eight stories cleared 200 points and eighteen are new. A blog post complaining about Google

Fifty-nine stories cleared 200 points and seventeen are new. Unsealed briefs show OpenAI researchers measured the LibGen problem in optics and Hacker News posts, ASML sold zero chip tools in Europe this year, and a Vim undo file turned into an argument about duty of care.

Fifty-six stories cleared 200 points and nineteen are new. A forensics report reconstructs how a swarm of OpenAI agents chained a link shortener into a Hugging Face breach, Conversations quit Google Play after twelve years, and the D.C. Circuit

Goldman Sachs notes that nearly half of S&P 500 stocks now have a negative beta to the index—a distortion unseen since 1999. A deep forensic look at market breadth, circular vendor financing, Capex exceeding cash flows, and why the parallels to the 2000 bubble pop are more structural than superf

Fifty-three stories cleared 200 points and twenty-one are new. The Dutch government shipped a NixOS workplace for its own employees, an appeals court upheld the Pentagon

Forty-five stories cleared 200 points and twenty-one are new. Anthropic

Fifty-eight stories cleared 200 points and twenty-four are new. The Pentagon blames Maven for a school strike it approved, a Jev clone fits in 25 lines, and half the front page is systems that break their primary function.

Fifty-six stories cleared 200 points and twenty-five are new. Three model launches in one day, Apple removing the off switch, and a cluster of essays about who actually writes the code.

Forty stories cleared 200 points and twenty-two are new. The last custody of the Snowden archive, Google

Forty-three stories cleared 200 points; only fifteen are new. OpenAI

Thirty-three stories cleared 200 points. Google is now gatekeeping Android APIs and security patches from non-Pixel OEMs, a 27B model got compressed to 5.9GB, OpenAI shipped a legal index and published the number that matters, and the most-loved thing on the front page is a bird frame.

영어와 함께 한글로도 생각과 기술적인 이야기들을 나누기 위해 다국어 지원을 추가했습니다.

A passkey backlash, a browser-local model that renames itself mid-story, an RCE chain into OpenAI

Japan

One-shotting is the easy part. The value is in shots two through a thousand — and that

Bird-drawing e-ink frames, AI hacking scandals, US space weapons, mass surveillance at 25, and the death of CSS-Tricks.

Valve enters the VR ring with Steam Frame, OpenAI

The technical excuse is gone. AI won

AI agents still cheating at chess, Tesla accidentally cyberattacking an NTP volunteer, JetKVM

Nvidia as AI

Anthropic gates Claude behind age verification, OpenRouter

Every frontier LLM in 2026 is still a Transformer. But the 2026 Transformer would be unrecognizable to a 2017 researcher. Here

Apple