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John Tyson

@drt1973.bsky.social

178 followers 144 following 3 posts

Senior Scientist BCCDC in Microbial Genomics and itinerant Nanopore tinkerer

Posts Replies Media

Reposted by John Tyson

Josh Quick @scalene.bsky.social · 22/05/2026

New preprint from us! 🦠 Clinical metagenomics is great for sequencing pathogens directly from patient samples but for some protocols sensitivity for RNA viruses lags behind bacteria & fungi. We have shown why, and how to fix it. www.medrxiv.org/content/10.6...

medrxiv.org

Library preparation strategy critically impacts RNA virus sensitivity in clinical metagenomics

Clinical metagenomics uses sequencing for culture-independent identification of pathogens directly from clinical specimens. While a number of protocols claim to be pathogen agnostic, sensitivity for R...

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Reposted by John Tyson

Kristian G. Andersen @kgandersen.bsky.social · 24/02/2026

New preprint from our Gates-funded Modjadji initiative showing that whole-genome surveillance of measles virus from wastewater greatly expands our ability for monitoring and control. Here, with our colleagues in South Africa - U.S., unfortunately, likely up next. www.medrxiv.org/content/10.6...

medrxiv.org

Integrating measles wastewater and clinical whole-genome sequencing enables high-resolution tracking of virus evolution and transmission

Measles outbreaks have surged globally in recent years, but current surveillance systems have limited capacity to monitor measles virus (MeV) transmission and evolution at population scale. Although M...

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John Tyson @drt1973.bsky.social · 24/02/2026

In light of recent P2 solo developments have dusted off an old image and updated it a little …….. 😉 @nanoporetech.com

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Reposted by John Tyson

Chris Kent @chris.primalscheme.com · 25/05/2024

Very excited to be using the soon-to-be released MK1D for HBV sequencing from Uganda!

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Reposted by John Tyson

Jared Simpson @jaredsimpson.bsky.social · 29/02/2024

For a few years I've been thinking about calling somatic mutations without matched normals using long read haplotypes. I've posted a preprint with my experiments to explore when this works (and when it doesn't) and developing a prototype mutation caller ("smrest"): www.biorxiv.org/content/10.1...

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