iiinova — where your digital self keeps evolving

Dr Lipid @drlipid.bsky.social · 10/05/2026

Here is the link to the full National Lipid Day Podcast with Peter H Jones interviewing me --www.youtube.com/watch?v=pLASk62Xu1c @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social @nationallipid.bsky.social @menopausesociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 02/05/2026

Lp(a) and Women: - "it is crucial that the risks associated with elevated Lp(a) levels in women are appropriately recognized by health care professionals to ensure the effective management of CVD risk and optimal CVD prevention in clinical practice" www.jacc.org/doi/10.1016/j.jacadv.2026.102744

jacc.org

Lipoprotein(a) and Women’s Cardiovascular Health: A Review

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Dr Lipid @drlipid.bsky.social · 27/04/2026

Thanks to my brainiac friend Dr Kellyann Niotis for alerting me about this freebee. AD Facts and Figures 2026 edition. Remember controlling CV health is essential to keeping the brain healthy. www.alz.org/getmedia/ef8... @nationallipid.bsky.social @eassociety.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 26/04/2026

Continuing with my graphics on the relationship of NMR lipoprotein particle metrics that relate to insulin resistance. Here is Part (2) still looking at VLDL Particle metrics pubmed.ncbi.nlm.nih.gov/12540621/ @nationallipid.bsky.social @aspcardio.bsky.social @eassociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 26/04/2026

Here is the relationship of NMR lipoprotein particle metrics that relate to insulin resistance. Over next few days I will graphically display the findings. Part (1) looks at VLDL Particles, specifically Large VLDL-P & VLDL size pubmed.ncbi.nlm.nih.gov/12540621/ @nationallipid.bsky.social

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Dr Lipid @drlipid.bsky.social · 15/04/2026

2002 vs 2026 Evidence - In current issue, evidence links heart disease to inflammation—and drugs can stop it | Scientific American www.scientificamerican.com/article/new-evidence-links-heart-disease-to-inflammation-and-drugs-can-stop-it/ @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 14/04/2026

More on the amazing story of CETP inhibition with obicetrapib - was associated with attenuated decline in kidney function in patients at high CV risk: Post hoc pooled results from the BROADWAY and BROOKLYN trials doi.org/10.1016/j.aj... @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 08/04/2026

To sum up the Metabolic Vulnerability Index (MVX), we are fortunate to have my friend and developer of the MVX technology, Jim Otvos, provide his great comments (CLICK to ENLARGE). Test is available @Labcorp. I will be getting my test this week @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 03/04/2026

Metabolic Vulnerability Index: MVX - Final Tutorial: UK Biobank Data. Test available @Labcorp pubmed.ncbi.nlm.nih.gov/41220154/ doi.org/10.1016/j.re... @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @eassociety.bsky.social @menopausesociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 02/04/2026

Metabolic Vulnerability Index (MVX) Tutorial #5: Data from CATHGEN and Intermountain Health Studies. More to come in Tutorial #6. MVX is available @Labcorp Paper is Open Access at pubmed.ncbi.nlm.nih.gov/36738747/

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Dr Lipid @drlipid.bsky.social · 30/03/2026

New mega-analysis showing statin therapy is associated with reduced risk of AD and related out comes, pubmed.ncbi.nlm.nih.gov/41761642/ @nationallipid.bsky.social @aspcardio.bsky.social @fabyollaveras.bsky.social @menopausesociety.bsky.social @eassociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 28/03/2026

Metabolic Vulnerability Index (MVX) Tutorial #3: Moving on to the Metabolic Malnutrition Index (MMX) component of the MVX available at Labcorp Open Access at pubmed.ncbi.nlm.nih.gov/36738747/ @nationallipid.bsky.social @aspcardio.bsky.social @eassociety.bsky.social @menopausesociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 28/03/2026

AFib and n3FA?? STRENGTH Trial tested high dose n3 carboxylic fatty acid (CA) drug (Epanova). Amongst 6,000 ω-3 CA group and 6,012 placebo group patients without history of AF, 126 (2.1%) and 75 (1.2%) developed AF. SMALL RISK RISKwww.sciencedirect.com/science/article/pii/S2666667726001777

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Dr Lipid @drlipid.bsky.social · 27/03/2026

Metabolic Vulnerability Index (MVX) Tutorial #2: After GlycA, one needs to learn more about the Inflammatory Vulnerability Index (IVX) component of the MVX @Labcorp Paper is Open Access at pubmed.ncbi.nlm.nih.gov/36738747/ @nationallipid.bsky.social @aspca.org @eassociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 27/03/2026

For Lipidologists: How are HDLs lipidated via the sterol efflux transporter ABCA1? Here is an advanced review by several notable HDL researchers www.ahajournals.org/doi/10.1161/... @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @eassociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 26/03/2026

Before continuing with the MVX discussion I first have to go deep into some clinical chemistry re one of its key components, specifically the stable & reliable inflammatory test called GlycA Open access at pubmed.ncbi.nlm.nih.gov/32363327/ @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 25/03/2026

Metabolic Vulnerability Index (MVX) Tutorial #1: More to follow. Test is available at @Labcorp Paper is Open Access at pubmed.ncbi.nlm.nih.gov/36738747/ @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @escardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 24/03/2026

See this new useful panel offered at @Labcorp namely the Metabolic Vulnerability Index (MVX). It consists of 6 NMR biomarkersthat help predict mortality rather independent of other risk factors. Stay tuned for much more www.labcorp.com/tests/123590/metabolic-vulnerability-index-mvx-by-nmr

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Dr Lipid @drlipid.bsky.social · 20/03/2026

Here is a fabulous "PERSPECTIVE" in Clinical Chemistry superbly written by The NIH Lipid lab team of Rafael Zubiran and Alan Remaley. It fabulously discusses nuances and complexities of CRISPR editing in general and for ANGPTL3 Article is at drive.google.com/file/d/1_hj0... @nationallipid

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Dr Lipid @drlipid.bsky.social · 19/03/2026

Do yourself a big favor and listen to this wonderful and informative~30 minute interview with one of the giants of lipidology @JohnKastelein www.youtube.com/watch?v=Bdl-InjA2_s @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social @eassociety.bsky.social

youtube.com

E29: John J.P. Kastelein

YouTube video by EAS - European Atherosclerosis Society

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Dr Lipid @drlipid.bsky.social · 16/03/2026

Brain Awareness Week is celebrated annually in the third week of March globally. Here is a reminder that cholesterol homeostasis is critical to brain health lnkd.in/e7Mn-XSW @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @menopausesociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 09/03/2026

Statins enter every cell in the body including the brain as they can pass thru the BBB. Statin's CV benefit comes from reducing apoB, by inhibiting HEPATIC cholesterol synthesis which in turn upregulates LDL receptor & the liver, has far more LDLRs than other peripheral tissues.

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Dr Lipid @drlipid.bsky.social · 09/03/2026

Nice to join several top neurologists on this paper. A Preventive Neurology Perspective on Promoting Brain Health and Preventing Cardiovascular Disease. Clin Geriatr Med 2026 doi.org/10.1016/j.cg... @nationallipid.bsky.social @aspcardio.bsky.social @eassociety.bsky.social

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Dr Lipid @drlipid.bsky.social · 02/03/2026

There are 2 forms of cholesterol - An alcohol ending in -OL (the active "free" form) & an ester ending in -YL (the storage/transportation form). The esterifying enzymes attach an acYL group (fatty acid) to free cholesterol are ACAT 1 & 2 in specific cells & LCAT (alpha and beta) within lipoproteins

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Dr Lipid @drlipid.bsky.social · 02/03/2026

CIMT can be even more important than CAC as vascular pathology appears before calcification. A significant proportion of low-risk individuals may have undetected plaque, justifying reconsideration of early screening strategies. Open access at pubmed.ncbi.nlm.nih.gov/41449009/

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Dr Lipid @drlipid.bsky.social · 01/03/2026

More Basics: Apart from biochemistry there is Clinical Chemistry and the cellular machinery that control everything. @nationallipid.bsky.social @aspcardio.bsky.social @familyheartfdn.bsky.social

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Dr Lipid @drlipid.bsky.social · 27/02/2026

This is a 9-minute podcast in the famed Lipid Curious series by Visha Priya Pulipati that sort of positions who I am and how I got there. I stumbled into and tried to master the importance of lipids before most clinicians. Enjoy. www.buzzsprout.com/2508586

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Dr Lipid @drlipid.bsky.social · 22/02/2026

More of my teaching slides to help all better understand lipid and lipoprotein complexities. Wish you could view the animated versions. Note: lab lipoprotein cholesterol assays measure both free and esterified cholesterol. See if you can figure out why one of obicetrapib's trials was called TULIP.

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Dr Lipid @drlipid.bsky.social · 19/02/2026

New AHA pediatric hypertriglyceridemia guideline - www.ahajournals.org/doi/10.1161/ATV.0000000000000195 @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 17/02/2026

Part of the HDL story not usually taught: After receiving TG from apoB particles via CETP, HDLs undergo lipolysis via the actions of hepatic & endothelial lipase. Ultimately the products of lipolysis are very small HDLs & apoA-I which are handled by the Megalin/Cubam complex in the renal tubules

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Dr Lipid @drlipid.bsky.social · 15/02/2026

These HDL slides illustrate some of the many complex pathways used by HDL's as it contributes to cholesterol homeostasis. Of course, the HDL-C metric tells you nothing about whether these pathways are occurring or not. If you are using any ratio that includes HDL-C, please cease immediately.

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Dr Lipid @drlipid.bsky.social · 08/02/2026

To help all better understand lipoprotein concentrations. Moles are a way of counting #s & 1 mole is the # of particles or 10 to the 23rd power & a nanomole is a billionth of a mole or 10 to the 9th power. HDLs BY FAR are the most numerous particles in plasma & VLDLs & IDLs are by far the fewest.

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Dr Lipid @drlipid.bsky.social · 30/01/2026

Here is where we are with PCSK9 inhibitors: 3 on the market, another (new class of drugs) just approved and coming in the near future an oral one. @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social

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Dr Lipid @drlipid.bsky.social · 26/01/2026

Demand your labs to start using this NIH developed extremely accurate LDL-C calculation (Modified Sampson) even when TG are high. Stop ordering direct LDL-C. LabCorp. is now using this equation. myadlm.org/cln/articles/2026/januaryfebruary/update-to-equation-for-estimating-ldl-c-proposed

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Dr Lipid @drlipid.bsky.social · 26/01/2026

Here is another of my graphics: this time on atherogenesis. The sine qua non means there cannot be atherosclerosis unless there are cholesterol molecules in the arterial wall. Over a long time, they are delivered by apoB-containing vehicles called lipoproteins, the vast majority of which are LDLs.

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Dr Lipid @drlipid.bsky.social · 24/01/2026

Here is a learning experience on a crucial topic to put at the top of your list. I so enjoyed listening to two of my favorite colleagues discussing the brain during the menopause transition. @_CynthiaThurlow and Dr Kellyann Niotis www.cynthiathurlow.com/podcast/epis...

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Dr Lipid @drlipid.bsky.social · 22/01/2026

Had 2 hours with Dr Frederick Feit on SiriusXM radio this morning. I spun a lot of lipids/lipoproteins & took several calls. If you are a subscriber to that channel, the chat is archived there for relistening. www.siriusxm.com/player/episode-audio/entity/98cd4f0e-aad6-e0ae-566c-77c64cd526c7

siriusxm.com

Lipidology, Cholesterol, Treatment | SiriusXM

Interventional Cardiology

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Dr Lipid @drlipid.bsky.social · 20/01/2026

Tomorrow from 6-8 AM, on @SIRIUSXM I will be a guest of famed cardiologist Dr Frederick Feit on Doctors Radio channel. I am the official historian and "Honorary Battalion Chief at the 211-year old Paterson NJ Fire Department. See www.patersonfirehistory.com/pfh-contribu...

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Dr Lipid @drlipid.bsky.social · 15/01/2026

Set your alarm clocks - I will be interviewed by renowned cardiologist Dr Frederick Feit on SiriusXM Doctor's Radio (Channel 110) live between 6:00 and 8:00 AM EST next Wednesday, January 21 (repeated periodically). Discussing what else - lipids, Menopausal Health & answering caller's questions.

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Dr Lipid @drlipid.bsky.social · 01/01/2026

Happy New Year to Lipidaholics - First lesson of 2026 providing some basics on Low Density Lipoproteins (LDLs): (1) Structure (2) Properties (3) Particle & cholesterol metrics (4) Changing apoB mass metrics (mg/dL) to particle numbers (nmol/L). @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 30/12/2025

I am happy to be included on this excellent 2025 Wrap Up with various podcast clips by some key experts @theproof discussing ASCVD, Lipids, Lipid targets, Lp(a), Hypertension, Keto trial, Nutrients, Cancer and much more. youtu.be/GMB9zFdaiaA?... @nationallipid.bsky.social @aspcardio.bsky.social

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Dr Lipid @drlipid.bsky.social · 23/12/2025

For Lipidologists and lipid interested folks: More on Lysine binding domains on apo(a) component of Lp(a) and the assay measuring oxPL-apoB (oxidized phospholipids on apoB) @nationallipid.bsky.social @aspcardio.bsky.social @escardio.bsky.social @familyheartfdn.bsky.social

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Dr Lipid @drlipid.bsky.social · 11/12/2025

Among 450,177 individuals with fibroids and 2,250,885 controls (mean age: 41 years, SD 6.3), uterine fibroids were associated with sustained increased ASCVD risks up to 10 years postdiagnosis, supporting targeted ASCVD prevention: OPEN ACCESS www.ahajournals.org/doi/10.1161/JAHA.125.044014

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Dr Lipid @drlipid.bsky.social · 06/12/2025

For those interested in quickly increasing their understanding of lipids and lipoproteins take a peak at this site called Lipid Curious" by endocrinologist/Lipidologist Vishnu Priya Pulpati that offers 10 concise podcasts www.buzzsprout.com/2508586/epis... or podcastindex.org/podcast/7364...

buzzsprout.com

LipidCurious

Podcast dedicated to demystifying lipids for medical boards and real-world clinical practice.

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