SLE neutrophil transcriptome and activated phenotype is regulated by small noncoding RNAs and alternative splicing of genes.

In this study we have combined RNAseq with functional experiments to describe the phenotype of neutrophils from people with frailty. We found that frailty

Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y...

IntroductionAmyloid deposition and inflammation are associated with many human diseases, with inflammatory cells found co-localised with amyloid in a range o...

In this study we have taken a multiomics approach to study metabolism (NMR Metabolomics) and gene expression (RNA sequencing) in blood neutrophils from adu

Background: Immune function alters with age, and is often accompanied by chronic, low-grade inflammation (inflammageing). In individuals with frailty, inflammageing is increased, reducing immune funct...

All the highlights from our Early Career Researcher event in central London on 19 November 2025, including the speakers and panel.

We spoke to three Vivensa-funded researchers about the power of patient, carer and public involvement and engagement (PPIE).

AbstractObjectives. Activation of neutrophils and release of neutrophil extracellular traps (NETs), proteases and reactive oxygen species (ROS) is pathogen

Introduction Rheumatoid arthritis (RA) is an auto-immune disease which causes irreversible damage to tissue and cartilage within synovial joints. Rapid diagnosis and treatment with disease-modifying t...

Rheumatoid arthritis neutrophils have heterogeneous gene expression profiles associated with neutrophil polarization and activation states, which we propos

Drowning is not the violent, splashing call for help that most people expect.