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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 16/12/2025

They used the C word ... Q: What CAUSES insulin resistance? A: The toxic enzymes of gum disease bacteria. (Note: Other mechanisms of insulin resistance involving the biological actions of dysbiotic oral bacteria are available.)

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/12/2025

The mouth is an immune organ. Gum disease is an open wound. Ignoring gum disease and the bacteria which inhabit inflammed gums means ignoring the driver of multiple systemic diseases. #OralHealth matters! 5/5

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/12/2025

Gum disease is not just a local problem for the mouth - it’s a central hub of systemic disease. And what goes around comes around. It is not just a bidirectional (two-way) process. Multiple systemic diseases are the same as gum disease, just in different parts of the body. 4/5

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/12/2025

The bacteria of #GumDisease / #OralDysbiosis don’t just travel - they subvert our immune system, fuel systemic inflammation, and contribute to cardiovascular disease, Alzheimer’s, diabetes, autoimmunity, gut diseases, lung diseases, cancers, and pregnancy complications ... 3/5

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/12/2025

Chronic gum inflammation and #OralDysbiosis go hand in hand, leading to inflammatory bacteria repeatedly seeding the gut, lungs, and body organs via the bloodstream (our blood vessels, brain, pancreas, liver, joints, kidneys, placenta etc.) ... 2/5

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/12/2025

We obsess about probiotics and food for gut health, but ignore the harmful ecosystem we are actively cultivating in our own mouths ... 1/5

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 11/07/2025

Not as much as there should have been. Do you have something in mind? Or a question?

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 05/06/2025

True. Just saying, to study the gut microbiome without also studying the oral microbiome is like studying the tubes of a trombone without its mouthpiece and wondering where the music comes from. The oral microbiome determines the gut microbiome. And the oral microbiome translocates systemically.

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 04/06/2025

Hi David. Correct! But the gut microbiome is downstream from … The oral microbiome. See this study from 2021 👇 pmc.ncbi.nlm.nih.gov/articles/PMC... And remember … 👇 Oral pathobionts have direct systemic vascular entry (bypassing the liver) via oral mucosa/diseased gums.

pmc.ncbi.nlm.nih.gov

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID

In the COVID-19 pandemic, caused by SARS-CoV-2, many individuals experience prolonged symptoms, termed long-lasting COVID-19 symptoms (long COVID). Long COVID is thought to be linked to immune dysregu...

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Reposted by Dr Graham Lloyd-Jones

Dr Rae Duncan @sunny-rae1.bsky.social · 21/04/2025

Published today after 2years of work behind the scenes by us at WHN/DELPHI Executive team : Our Global Expert DELPHI Consensus document on Long Covid. 179 Experts from 28 countries around the Globe Participated. Please share. Happy Easter! link.springer.com/article/10.1...

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 18/04/2025

Dear #MedBlueSky Black and white EITHER/OR debates limit us. Nuanced AND/BOTH debates provide answers. Let's not oversimplify the human body. It is too complicated to be understood in terms of binary EITHER/OR stances. The nuance of AND/BOTH is the way forward. Thanks

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

… to ensure correct language is used to describe a disease (not old and potentially misleading language) And … To allow challenges to incorrect concepts, to stop them propagating and becoming fixed dogma in the medical literature. 25/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

I'm now working with likeminded radiologists on an invited review of #COVID imaging for a major radiology journal. We propose formation of a system by which all medical/scientific specialties collaborate to build understanding when we encounter a new disease … 24/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

My frustration with the world of medicine (my world) is that we are pathologically unable/unwilling to shift ideas or to see the body holistically. Our blinkered and siloed approach kills people! Oral health is the most siloed of all areas of medicine. 23/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

In summary, gum disease bacteria escape the mouth all the time and are directly implicated in biological mechanisms of numerous common diseases of the body including cardiovascular disease, diabetes, 22/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

What have I learned from COVID-19? … That our lack of understanding of the biology of the mouth and the importance of #OralHealth is the biggest missing link in the whole of medicine. youtu.be/yLhtBZIaAIk 21/25

youtu.be

COVID-19 and the Salisbury Oral Care Pathway

YouTube video by Salisbury District Hospital

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

The concept of pathogens escaping the mouth and travelling to the rest of the body is now my major area of interest (writing a book). 20/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

This question led to hypothesizing that the virus is getting to the lungs from the upper respiratory tract (nose and mouth) via the bloodstream. And this explains why gum disease is a major risk factor for death from COVID-19. link.springer.com/article/10.1... 19/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

The pattern of lung disease we saw on medical imaging in people with #COVID-19 tells us that the disease is NOT pneumonia, it is a vasculopathy (disease of blood vessels). This raises another question … How does this happen? 18/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

You might think that medical organisations asked – what are we dealing with? They didn’t! They assumed it was just like influenza. They kept calling the disease ‘pneumonia’. This was a fatal error. 17/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

At the outset of the pandemic, ‘experts’ were called on to advise on population level planning. This is fine (if you like graphs), but we also need a multidisciplinary approach to attempt to understand the biological mechanisms of the disease we are dealing with. 16/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

Not ... What old language can we use to describe this disease? But ... What is different? What is new? What don't we understand? And ... How can we collaborate to build a multidisciplinary understanding of diseases processes? 15/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

I am posting this story now so that we (humans) can learn some lessons. When we encounter a new disease, we should all stop and ask .... What are we dealing with? Not ... How is this similar to other diseases we know about? 14/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

Here is our conclusion … (Remember, this is 2020 data which could have been published in early 2021) 13/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

After many attempts to get published we were eventually accepted this month (April 2025!) in an institutional journal. (Thanks to @UMJBelfast. And thanks especially to my colleague Alastair Watson for not giving up hope of publication.) bit.ly/4j6fIpx 12/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

The airways of the lungs were NORMAL! Unlike influenza, there was no inflammation in the lung airways in people with #COVID-19. The blood vessels were damaged. And yet the world of medicine carried on treating it as if it were flu. 11/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

This led to an invitation to join the REACT COVID-19 research group based in Southampton, UK. I was initially the sole radiologist on the project. People from across the world sent me examples of COVID-19 cases. I looked at thousands of images. The same pattern was repeated … 10/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

In November 2020 I was invited to speak at the @BritSocHaem annual conference. The talk highlights that #COVID-19 is NOT a pneumonia. It is a pulmonary vasculopathy (disease of the lung blood vessels). youtu.be/2jROYLwUK20 9/25

youtu.be

COVID-19 Lung Disease: A Pulmonary Vasculopathy

YouTube video by Radiology Masterclass

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

So I published informally as a blog on the Radiology Masterclass website and shared my ideas widely. bit.ly/3E6PX9D 8/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

In June 2020 I wrote to a UK radiology journal to raise the alert. The title of my letter was – ‘Acute COVID-19 lung disease: A pulmonary vasculopathy not a pneumonia’ I was told it would be too ‘time-consuming’ to be put forward for publication. 7/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

Soon the autopsy papers showed that clotting in the lungs was occurring in the capillaries (the smallest blood vessels). This means that we would not be able to detect clotting in the lungs using standard imaging techniques. bit.ly/3XSg8aM 6/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

I wanted to know WHY #COVID-19 caused this weird ‘pneumonia’. The areas of lung damage looked like what we see when someone has blood clots in the lungs. bit.ly/4j6fIpx 5/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

The early papers from China showed distinct patterns of lung damage on CT scans which helped to make the diagnosis, but this was not the main question I had. bit.ly/43PTfZi 4/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

In early 2020 I had an obvious job to do – teach doctors to make the diagnosis of COVID-19 on a chest X-ray or CT scan. Making the diagnosis is easy because COVID-19 causes a lung disease which is totally unlike other ‘pneumonias’. bit.ly/3XSvMmr 3/25

bit.ly

COVID-19 Image Gallery

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

Firstly, who am I? I am an educator in medical imaging, best known for founding Radiology Masterclass, a leading online resource for radiology education. www.radiologymasterclass.co.uk 2/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 13/04/2025

If in Dec 2020 you had told me it would take until April 2021 to get my #COVID research published, I’d have been disappointed. It has now been published (April 2025), 4 years later. bit.ly/4j6fIpx 👇 Here's my epic COVID-19 failure story … Long thread 1/25

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 29/03/2025

My heart is in my mouth, my friend, and yours is in yours🤩

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 29/03/2025

Only for doctors who might be interested in biological mechanisms of cardiovascular risk… But it can’t be important coz it’s about the mouth. And we all know the mouth is not really a part of the body, right? #OralMicrobiome #EnteroSalivaryNOPathway www.ahajournals.org/doi/10.1161/...

ahajournals.org

Nitrite Generating and Depleting Capacity of the Oral Microbiome and Cardiometabolic Risk: Results from ORIGINS | Journal of the American Heart Association

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 25/03/2025

IndieSage did a great job and I was glad to play a small role. As well as a system to understand options for populations we need a collaborative multidisciplinary system for understanding the pathogenesis of a new disease. Next time let’s not assume it is influenza and describe using old language.

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Reposted by Dr Graham Lloyd-Jones

British Dental Association @thebda.bsky.social · 15/03/2025

A Question to Which the Answer is Yes #QTWTAIY Industry have been flogging products sugarier than Coke to of infants. We lifted the lid on this scandal in 2022. 👇 www.theguardian.com/society/2025/ma…

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Reposted by Dr Graham Lloyd-Jones

The Food Foundation @foodfoundation.bsky.social · 06/03/2025

🥣 Did you know only 3% of breakfast cereals and 5% of yogurts marketed to children are low in sugar? We'd like retailers to reformulate products and stop marketing unhealthy food to children. Read more: bit.ly/3PR0Gal #BrokenPlate #HFSS

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 06/03/2025

It’s almost as if neurodegenerative diseases are not ‘non-communicable’ after all. What could be going on? #PGingivalis #TranslocationFromMouthToBrainViaBloodstream #BloodBrainBarrierIsntABarrier

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 06/03/2025

It is not possible to understand #Alzheimer’s disease without understanding the involvement of #OralMicrobiome pathogens. Not only is Alzheimer’s a disease, it is a microbial ecosystem. #PGingivalis #OralBacterialTranslocation #OuterMembraneVesicles #Lactoferrin #Neuroinflammation #IronMetabolism

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 25/02/2025

Interesting! Will this be available to watch online too?

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 25/02/2025

You and Alice did a great job, Caroline. There’s at least another 8 hours of material if you want it 😀 (Do you know anyone who could do a podcast?)

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 23/02/2025

Some Sunday listening for you. In this BBC Radio 4 programme I talk about the importance of oral health for the health of your body. Presented by @carolinesteel.bsky.social and featuring her visit to Salisbury Hospital 👇👇👇 bbc.co.uk/sounds/play/m00283bm

bbc.co.uk

Mouth Organ - BBC Sounds

Caroline Steel finds out why we need to put the mouth back in the body.

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Reposted by Dr Graham Lloyd-Jones

Caroline Steel @carolinesteel.bsky.social · 19/02/2025

I’m on Radio 4 NOW learning about how the bacteria in our mouths affect our overall health. There are links between our mouth health and diabetes and Alzheimer’s 🤯 With @drgrahamlj.bsky.social www.bbc.co.uk/programmes/m...

bbc.co.uk

BBC Radio 4 - Mouth Organ

Caroline Steel finds out why we need to put the mouth back in the body.

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Dr Graham Lloyd-Jones @drgrahamlj.bsky.social · 20/02/2025

In simple terms, #COVID is all* about oral biology and damage to endothelial cells (cells which line our blood vessels), and nothing* to do with inflammation in the airways of the lungs. 4/4 *caveats are available

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