iiinova — where your digital self keeps evolving

Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 25/09/2026

Register now for our welfare webinar exploring the role of anaesthesia and analgesia as key refinements for fish used in research. 📅 22 October, 12.30 – 13.30.  🙋🏻‍ For researchers, animal technicians and veterinarians 📜 Certificates of attendance available 👉 nc3rs.org.uk/events/welfa...

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Esther Pearl @drejpearl.bsky.social · 23/09/2026

Would you like a little extra help designing in vivo experiments? Join me on 29 September as I demonstrate how to use the @nc3rs.bsky.social's Experimental Design Assistant (EDA). nc3rs.org.uk/events/exper...

nc3rs.org.uk

Experimental Design Assistant virtual workshop

An interactive online workshop on using the Experimental Design Assistant (EDA), online software to help design rigorous in vivo experiments.

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Esther Pearl @drejpearl.bsky.social · 18/09/2026

Looking forward to joining the panel for the ‘Rigorous by design: Strengthening research that involves animals’ webinar from the @nationalacademies.org. Register to hear about improving the reliability of results by carefully planning and reporting your experiments. 👇

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 17/09/2026

Join us at next week’s welfare webinar to hear about the latest evidence and practical advice on skin swabbing as a refined alternative to fin clipping for fish DNA sample collection. 📅 Thursday 24 September, 12.00 – 13.00 ⏰ Registration closes: Wednesday 23 September 👉 nc3rs.org.uk/events/welfa...

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Esther Pearl @drejpearl.bsky.social · 15/09/2026

I attended my first @royalstatsoc.bsky.social conference last week. An amazing conference! Everyone was so welcoming. Many talks mentioned the need for well designed experiments and emphasised that statisticians should get talking to researchers early on and plan projects together. 100% agree.

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Esther Pearl @drejpearl.bsky.social · 10/09/2026

Do you work with Xenopus? Want to know the latest best practices in housing and husbandry? Want tips for implementing reduction and refinement? Check out the new Xenopus protocols book 👇

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Esther Pearl @drejpearl.bsky.social · 07/09/2026

I’ve ARRIVEd (!) at the 2026 @royalstatsoc.bsky.social conference. Looking forward to a great meeting! Are you at the conference and wondering what sessions to attend? Tomorrow, Penny Reynolds, William Browne and I are talking about biomedical research study design. Join us!

Image of pocket sized ARRIVE guidelines in front of the RSS conference welcome banner

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Esther Pearl @drejpearl.bsky.social · 01/09/2026

I am excited to be attending my first ever @royalstatsoc.bsky.social conference this year! Drs Penny Reynolds, William Browne and I will be presenting 'Biomedical research study design: Back to basics in the age of AI'. 🗓️ Tuesday 8 Sept 15.40 - 17.00 I hope to see you there!

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 25/08/2026

Register now for our upcoming welfare webinar on fish skin swabbing for refined DNA sampling. 📅 24 September, 12.00 – 13.00 🧑‍🔬 For researchers, animal technicians and veterinarians 📜 Certificates of attendance available 👉 nc3rs.org.uk/events/welfa...

Skin swabbing a zebrafish as a refined technique for DNA sampling.

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 21/08/2026

In our latest blog Fiona Sewell, NC3Rs Head of Toxicology, discusses collaborating with the global community on one of the most challenging questions in regulatory science – how to balance assuring human reproductive health with avoiding unnecessary animal suffering: nc3rs.org.uk/news/finding...

Timeline showing NC3Rs-led collaboration to improve dose-level selection in developmental and reproductive toxicity (DART) studies. Between 2022 and 2026, publications, workshops, symposia and stakeholder engagement helped clarify regulatory guidance, contributing to ECHA updating its advice and supporting more consistent, scientifically justified dose setting that reduces unnecessary animal suffering and minimises the risk of additional animal use in further studies.

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Esther Pearl @drejpearl.bsky.social · 31/07/2026

📄Transparently and comprehensively reporting animal research is important for both research quality and the 3Rs. ✍️Penny Reynolds and I have recently written an article looking at the progress we have made in reporting research involving animals, what we still need to tackle and future directions. 👇

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Esther Pearl @drejpearl.bsky.social · 22/07/2026

Do you serve on, support, or advise an Animal Research Governance Committee (e.g., AWERB, IACUC, or Animal Welfare Committee) that reviews in vivo research applications? Would you like support to help you check if research protocols are sex-inclusive?

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 01/07/2026

The fifth annual Galleria mellonella workshop returns with a two-day programme including a research seminar and hands-on laboratory sessions. Organised by @gmrc.bsky.social to support the use of Galleria as a partial replacement model. 📅 8 – 9 September 📍 Exeter, UK 👉 nc3rs.org.uk/events/galle...

Wax moth larvae, Galleria mellonella, in a laboratory petri dish.

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Reposted by Esther Pearl

Xenbase @xenbase.bsky.social · 25/06/2026

2026 Xenopus Researcher Survey - OPEN NOW - forms.gle/uDUkGCrhpXCc... Your feedback is highly valuable. Help us make Xenbase more helpful to your research! #science #devbio #cellbio #xenopus #frogs

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 25/06/2026

3Rs leaflets are available to engage public audiences about efforts to replace, reduce and refine animal use in research: nc3rs.org.uk/3rs-resource... Created by Dr Yu Liu @mrc-lms.bsky.social with the support of the NC3Rs Communications Team and funding through our public engagement award scheme.

Information leaflets on the replacement, reduction and refinement of animal research, created through an NC3Rs public engagement award.

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Reposted by Esther Pearl

Lowe Lab @lowelab.bsky.social · 30/05/2026

Please repost !! SANTA CRUZ DEVELOPMENTAL BIOLOGY CONFERENCE 2026. Deadline to register your abstracts for the meeting is Monday June 1. Please get those abstracts in ! scdb2026.sites.ucsc.edu

scdb2026.sites.ucsc.edu

Santa Cruz Developmental Biology Meeting

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Esther Pearl @drejpearl.bsky.social · 28/05/2026

Very pleased to hear that Nature is expanding Registered Reports to all fields they publish. Registered reports put the focus on the research question and the quality of methods AND peer review helps you improve the methodology before you get started! What's not to like?? www.cos.io/initiatives/...

cos.io

Registered Reports

Peer review before results are known to align scientific values and practices.

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Esther Pearl @drejpearl.bsky.social · 11/05/2026

Want help making teaching experimental design more interactive? Join us in June for the NC3Rs/iRISE Train-the-Trainer workshop: Reproducibility & the Experimental Design Assistant (EDA)! 👇

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Esther Pearl @drejpearl.bsky.social · 11/05/2026

Looking for a way to make teaching experimental design more interactive? Join me, Gillian Currie and Sarah Morgan for the online Reproducibility and the Experimental Design Assistant Train-the-Trainers course 👇

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Esther Pearl @drejpearl.bsky.social · 06/05/2026

Earlier this year I ran an EDA train-the-trainers course for a group of enthusiastic trainers from CAMARADES Turkiye. They have gone on to train a further 178 researchers from 57 different institutions 🎉. This week? I am training a group from Argentina!

Graphic showing that CAMARADES Turkiye have 12 EDA trainers and they have trained 178 people from 57 institutes in 34 different cities. Participants were from 28 different research fields.

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 28/04/2026

The countdown is on! The deadline for applications to our international 3Rs Prize, sponsored by GSK, is fast approaching. Submit your publication for consideration by Monday 4 May 2026: nc3rs.org.uk/internationa...

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 13/04/2026

We are thrilled to be returning to @pintofscience.uk for our twelfth year as festival sponsors! Join us in Newcastle, Bristol and London as NC3Rs-funded scientists showcase innovations in replacement approaches and explore the future of alternatives to animals. 🎟️ pintofscience.co.uk/sponsor/nc3rs/

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Esther Pearl @drejpearl.bsky.social · 01/04/2026

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Esther Pearl @drejpearl.bsky.social · 19/02/2026

Join me next month to learn how to improve the rigour of your experiments with the EDA! 📅 Wednesday 4 March, 16.00 – 18.00 (GMT) Register here 👇

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Esther Pearl @drejpearl.bsky.social · 12/02/2026

Want a bit of extra help designing your next in vivo experiment? Join me on 4 March for a demonstration of the @nc3rs.bsky.social Experimental Design Assistant: nc3rs.org.uk/3rs-resource...

nc3rs.org.uk

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Esther Pearl @drejpearl.bsky.social · 16/01/2026

Join me next week at #LoveMethods26. I am running a workshop demonstrating the features of the online tool the Experimental Design Assistant including how it can help us clearly describe our experimental plans with collaborators, funders, ethical review bodies and in our publications. 👇

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Esther Pearl @drejpearl.bsky.social · 09/01/2026

Is your New Year’s Resolution to design more reliable experiments? Join me at my #LoveMethods26 Experimental Design Assistant workshop. You will have time to design your own experiment, with me on hand to answer questions and give you support. Register here: nc3rs.org.uk/events/love-...

nc3rs.org.uk

Love Methods Week: Rigorous experiments and clear communication with the Experimental Design Assistant

An online workshop including a demonstration of the EDA and live guidance to design your own experiment.

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Reposted by Esther Pearl

Rene Bernard @renebernard.bsky.social · 17/12/2025

Have you registered for #LoveMethods26 yet? Join us from Jan 19-23, 2026 with 19 online workshops and seminars focused on improving method reproducibility and transparency. Check it out: excelscior.uc.pt/love-methods...

excelscior.uc.pt

Love Methods Week 2026 – Excelsior

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Esther Pearl @drejpearl.bsky.social · 03/12/2025

Yesterday we were at @kingscollegelondon.bsky.social Faculty of Life Sciences & Medicine to help teach Masters’ students experimental design best practices. The @nc3rs.bsky.social’s Experimental Design Assistant helped students consider key concepts and understand how to implement them in practice.

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Esther Pearl @drejpearl.bsky.social · 27/11/2025

Looking forward to the @unistrathclyde.bsky.social 3Rs day where I will be helping people design more rigorous experiments with the help of the @nc3rs.bsky.social's Experimental Design Assistant.

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 12/11/2025

The NC3Rs has a strong track record in investing in in vitro models of human disease that replace the use of animals. We have recently partnered with the MRC, Wellcome and Innovate UK on a £15.9M funding call to develop human in vitro models of complex disease. nc3rs.org.uk/news/nc3rs-g...

nc3rs.org.uk

NC3Rs grant holders receive funding in MRC call

£15.9M awarded to develop human in vitro models of complex disease.

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 10/11/2025

❗Survey deadline extended: Friday 12 December❗ If you have experience of the monocyte activation test as a replacement for the rabbit pyrogen test, please take 30 minutes to share your insights: nc3rs.org.uk/our-portfoli...

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 03/11/2025

⏳ Pyrogenicity testing survey closing on Thursday 7 November. Please take 30 minutes to share your insights into the monocyte activation test and support our work to drive wider adoption of non-animal approaches in biologics quality control testing. Take the survey: nc3rs.org.uk/our-portfoli...

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Esther Pearl @drejpearl.bsky.social · 31/10/2025

Looking for a more interactive way to teach experimental design for researchers? Make the @nc3rs.bsky.social's Experimental Design Assistant (EDA) part of your course! For ideas check out how Inserm designed their course, including tips for others wanting to do something similar 👇

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Esther Pearl @drejpearl.bsky.social · 22/10/2025

Part of an ethical review body? Want more information on key considerations to help improve rigour and reproducibility of animal research? Check out the new chapter in the 4th edition of the IACUC Handbook: ‘Research Reproducibility and the Role of the IACUC’ www.taylorfrancis.com/chapters/oa-...

taylorfrancis.com

Research Reproducibility and the Role of the IACUC | 39 | v4 | The IAC

Institutional Animal Care and Use Committees (IACUCs) and equivalent oversight bodies, such as the United Kingdom (UK) Animal Welfare and Ethical Review Body

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Esther Pearl @drejpearl.bsky.social · 23/09/2025

The @nc3rs.bsky.social's Experimental Design Assistant (EDA) is back online following planned maintenance. Thank you for your patience.

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Esther Pearl @drejpearl.bsky.social · 23/09/2025

🚨⚠️ The @nc3rs.bsky.social's Experimental Design Assistant will be offline for planned maintenance today (Tuesday 23 September) from 4pm BST. Please ensure your work is saved before 4pm. We apologise for any inconvenience caused and will notify you when the EDA is back online. ⚠️🚨

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Esther Pearl @drejpearl.bsky.social · 19/09/2025

🚨⚠️The @nc3rs.bsky.social's Experimental Design Assistant (EDA) will be offline for planned maintenance on Tuesday 23 September from 4pm BST. We anticipate it will be back online by the morning of Wednesday 24 September. We apologise for any inconvenience caused.⚠️🚨

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Reposted by Esther Pearl

The Learning Curve (Development) Ltd @tlcdevelopment.bsky.social · 15/09/2025

Spaces still available for this excellent scientific webinar later this week - register via link below 👇

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 11/09/2025

Join us next week to learn more about misconceptions around sex-inclusive research and how the Sex Inclusive Research Framework can be used by scientists, ethical review bodies and funders: nc3rs.org.uk/events/tackl... 📅 18 September, 15.00 – 16.00 📜 One hour of continuing professional development

A black mouse with a litter of pups in a laboratory cage.

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Esther Pearl @drejpearl.bsky.social · 09/09/2025

Interested in tools to help teach experimental design? Is your institution part of the UKRN Open Research Programme? www.ukrn.org/partner-inst... 👇 Register for the online workshop on how to use, and teach others to use, the Experimental Design Assistant (EDA). Registrations close 17 September. 👇

ukrn.org

Partner Institutions

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 03/09/2025

We are supporting in-person training workshops to promote the use of skin swabbing as a refined approach for genotyping zebrafish. 🐟 Suitable for technical staff and researchers 🤝 Personalised support in small groups 📍 Delivered at your facility (UK only) Find out more: nc3rs.org.uk/training-wor...

A zebrafish is held in a hand net and swabbed.

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Esther Pearl @drejpearl.bsky.social · 01/09/2025

The @nc3rs.bsky.social contingent has ARRIVEd in Brazil for #WC13. Yesterday kicked off with the opening ceremony. Today join me in session 118: Ethics in action. I will be highlighting resources to support reduction and how ethical review bodies can use them.

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Reposted by Esther Pearl

NC3Rs @nc3rs.bsky.social · 26/08/2025

⏳ Registration closing on Thursday 28 August! Interested in driving the uptake and impact of 3Rs models and technologies through cross sector collaborations? Join us and the BBSRC in London on September 12 as we launch our new joint funding initiative. Find out more: nc3rs.org.uk/events/nc3rs...

Icons representing NC3Rs Networks in oncology, cardiovascular science and new approach methodologies for safety assessment.

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Esther Pearl @drejpearl.bsky.social · 22/08/2025

Now that the 20th International Xenopus conference is over it is time to rest my geeky earrings. I had a great time catching up with people and discussing welfare research priorities. Interested in the amphibian welfare webinars I mentioned? Here’s the link: nc3rs.org.uk/3rs-resource... #IXC25

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Esther Pearl @drejpearl.bsky.social · 19/08/2025

Having some great conversations about Xenopus welfare at the 20th International Xenopus conference. Also got to wear my Xenopus earrings!! #IXC25

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