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dorisloh.bsky.social

@dorisloh.bsky.social
221 followers 5 following 17 posts
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dorisloh.bsky.social @dorisloh.bsky.social · 21/09/2026
New melatonin research redefines mechanical regulation of cellular energetic engines. If you thought phase separation was groundbreaking, this perspective will open doors to new horizons you never imagined existed. Ready to tumble down the thermodynamic rabbit hole? 🔗https://tinyurl.com/bddhmhts
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dorisloh.bsky.social @dorisloh.bsky.social · 19/09/2026
Melatonin is the only endogenous, non-lipid molecule that can choreograph biophysical reactions across both 3D and 2D cellular spaces. Next week, we will unveil a novel, unexplored dimension where melatonin governs cellular energy across the 2D lipid landscape & 3D condensate axes. Stay tuned...
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dorisloh.bsky.social @dorisloh.bsky.social · 27/06/2026
Is melatonin just a sleep hormone? After you watch this mic-dropping video, you may have different ideas about melatonin. 🎬 Beyond the Sleep Hormone: How Melatonin Controls Cancer Cell Networks Watch: youtu.be/EgrLDqqBZ30 Listen: sl1nk.com/uc92c0x #SciSky #AcademicSky #Biophysics #Oncology
youtu.be
Beyond the Sleep Hormone: How Melatonin Controls Cancer Cell Networks
YouTube video by Doris Loh
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dorisloh.bsky.social @dorisloh.bsky.social · 19/06/2026
Cancer cells form phase-separated condensates that evade endogenous suppression and exogenous treatments. Melatonin is the Master Regulator that resculpts the cancer landscape to expose vulnerabilities that can be targeted by oncostatic therapies. Open Access onlinelibrary.wiley.com/doi/10.1111/...
An infographic diagram detailing the melatonin Sovereign Singularity framework, illustrating the multi-axial biophysical control systems and dynamic landscapes of a cancer cell cell.
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dorisloh.bsky.social @dorisloh.bsky.social · 17/06/2026
"Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines" is published at the Journal of Pineal Research. Here, melatonin is presented as a master biophysical regulator, dictating the physical boundaries of oncogenic phase separation and completely shifts the current paradigm.
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dorisloh.bsky.social @dorisloh.bsky.social · 19/02/2026
New Findings: Aging starts at the condensate level. Aged cells form protective but persistent stress granules (SGs) that are more viscous and contain less RNA. Removal of these aberrant SGs was achieved by restoring RNA metabolism and concentration. biorxiv.org/lookup/doi/10.64898/2026.02.16.705223
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dorisloh.bsky.social @dorisloh.bsky.social · 07/02/2026
Proud to announce our bioRxiv preprint: tinyurl.com/2k5a459h Kudos to co-authors Chuffa, Seiva, and Reiter for demonstrating a universal regulator that restores normal cellular phase behavior—disrupting the condensates cancer cells exploit. #PhaseSeparation #CancerResearch #Biophysics #Melatonin
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dorisloh.bsky.social @dorisloh.bsky.social · 17/06/2025
100 mg/kg melatonin achieved better results than 50 mg/kg in suppressing aggressive Ehrlich ascites carcinoma in mice. The question is, how much is a 100 mg/kg mouse dose for a 65kg human? Answer: 4600 mg (with adjustment for body surface area, metabolic rate, bioavailability, and administration).
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dorisloh.bsky.social @dorisloh.bsky.social · 27/05/2025
Why do cancer cells develop resistance to chemo drugs like doxorubicin? Doxorubicin interacts with the tumor suppressor gene p53 (wildtype and mutants) to cause phase separation and accelerated aggregation, leading to increased survival and proliferation. pubmed.ncbi.nlm.nih.gov/38435052/
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dorisloh.bsky.social @dorisloh.bsky.social · 17/05/2025
www.frontiersin.org/journals/pai...
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dorisloh.bsky.social @dorisloh.bsky.social · 21/04/2025
Worried about your pathogenic SNPs? Peer-reviewed 2025 paper shows how phase separation mediates non-coding SNP interactions with their target genes. When the transcription factor RUNX2 phase separates, it can recruit SNP rs4683184, associated with osteoporosis, to increase osteoblast production.
advanced.onlinelibrary.wiley.com
RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation
A GWAS intergenic SNP (rs4683184) acts as an enhancer, altering the binding affinity of the transcription factor RUNX2 and resulting in changes in XCR1 expression and osteoblast differentiation. RUNX....
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dorisloh.bsky.social @dorisloh.bsky.social · 09/04/2025
ATP is biphasic: low levels promote & high levels inhibit protein aggregation. Novel discovery shows a-Syn amyloids fully degrade ATP at normal cellular concentrations (2 mM), using it to stabilize pathological aggregations. tinyurl.com/e7626sc4 Melatonin complexes with ATP to inhibit aggregation.
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