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Donner Lab

@donnerlab.bsky.social
568 followers 1.2K following 74 posts

The goal of our research is to understand how brain states shape decision-making, and how this process goes awry in certain neurological & psychiatric disorders | tobiasdonner.net | University Medical Center Hamburg-Eppendorf, Germany

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Donner Lab @donnerlab.bsky.social · 14/09/2026
🎉🎓 Big congrats to @josefinehebisch.bsky.social who successfully defended her thesis " Through the Eye of the Beholder: Pupil-Linked Arousal in Memory Formation and Decision-Making" last week and earned her PhD "summa cum laude"! So proud of your accomplishments!
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Donner Lab @donnerlab.bsky.social · 25/08/2026
Sounds played during the presentation of images had a positive influence on image recall immediately after encoding. This positive effect could only be observed for images as this onset timing was not applied in the words task due to the auditory nature of word stimuli. 6/10
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Donner Lab @donnerlab.bsky.social · 25/08/2026
We replicated earlier correlational relationships. Higher task-evoked pupil-linked arousal during encoding of words predicted better recall one day later. Pupil responses during recognition decisions correlated with the old/new bias for both recognition decisions about words and images. 4/10
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Donner Lab @donnerlab.bsky.social · 03/11/2025
It fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
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Donner Lab @donnerlab.bsky.social · 03/11/2025
Our model combines sensory adaptation, leaky accumulation with feed-forward inhibition, and an asymmetric readout of the DVs in confidence formation.
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Donner Lab @donnerlab.bsky.social · 03/11/2025
We next used single-trial regression to predict confidence from the winning and losing DVs, controlling for evidence strength. Both DVs made a significant, unique contribution to confidence. However, in contrast to standard models, the magnitude of the winning DV was stronger.
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Donner Lab @donnerlab.bsky.social · 03/11/2025
Despite the independent inputs, we found intrinsic negative correlations between the two DVs within trials, a signature of inhibition between the sensory-motor pathways supporting the two alternative choices. The strength of this correlation on each trial predicted confidence.
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Donner Lab @donnerlab.bsky.social · 03/11/2025
We tracked the competition between neural decision variables (DVs) in the human frontal cortex, combining a novel task with atlas-based multivariate decoding of source-level MEG data to track two neural DVs for alternative choices in left and right premotor/motor cortex (PMd/M1).
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Donner Lab @donnerlab.bsky.social · 03/11/2025
It fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
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Donner Lab @donnerlab.bsky.social · 03/11/2025
Our model combines sensory adaptation, leaky accumulation with feed-forward inhibition, and an asymmetric readout of the DVs in confidence formation.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
We next used single-trial regression to predict confidence from the winning and losing DVs, controlling for evidence strength. Both DVs made a significant, unique contribution to confidence. However, in contrast to standard models, the magnitude of the winning DV was stronger.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
Despite the independent inputs, we found intrinsic negative correlations between the two DVs within trials, a signature of inhibition between the sensory-motor pathways supporting the two alternative choices. The strength of this correlation on each trial predicted confidence.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
We tracked the competition between neural decision variables (DVs) in the human frontal cortex, combining a novel task with atlas-based multivariate decoding of source-level MEG data to track two neural DVs for alternative choices in left and right premotor/motor cortex (PMd/M1).
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
It fits the behavioral data better than a range of alternatives, and reproduces a number of behavioral and neural signatures, including the concurrently measured dynamics of the encoding of contrast samples in visual cortex.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
Our model combines sensory adaptation, leaky accumulation with feed-forward inhibition, and an asymmetric readout of the DVs in confidence formation.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
We next used single-trial regression to predict confidence from the winning and losing DVs, controlling for evidence strength. Both DVs made a significant, unique contribution to confidence. However, in contrast to standard models, the magnitude of the winning DV was stronger.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
Despite the independent inputs, we found intrinsic negative correlations between the two DVs within trials, a signature of inhibition between the sensory-motor pathways supporting the two alternative choices. The strength of this correlation on each trial predicted confidence.
100
Donner Lab @donnerlab.bsky.social · 03/11/2025
We tracked the competition between neural decision variables (DVs) in the human frontal cortex, combining a novel task with atlas-based multivariate decoding of source-level MEG data to track two neural DVs for alternative choices in left and right premotor/motor cortex (PMd/M1).
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Donner Lab @donnerlab.bsky.social · 12/07/2025
Ayelet Arazi - 📍 Poster 3.5 | Wed (July 16th): Cortex-wide changes in neural dynamics in early-stage psychosis relate to GABA-A or NMDA receptor expression and function, and to clinical symptoms.
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Donner Lab @donnerlab.bsky.social · 12/07/2025
Gina Monov - 📍 Poster 2.13 | Tue (July 15th): Come explore our latest findings on cortical working memory dynamics in aging and MCI!
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Donner Lab @donnerlab.bsky.social · 12/07/2025
Alessandro Toso - 📍 Poster 1.4 | Mon (July 14th): Through pharmacological manipulations in humans, we showed that GABA-A and NMDA receptors shape perceptual decision-making at distinct timescales — within-trial and across-trial, respectively.
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