iiinova — where your digital self keeps evolving

Jennifer Estall @dnachicken.bsky.social · 08/02/2026

Join us in Vancouver for the Keystone MASLD/MASH meeting. On top of great science, it’ll definitely be warmer than the east coast :)

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Reposted by Jennifer Estall

Keystone Symposia @keystonesymposia.bsky.social · 05/12/2025

⏰ Deadline Dec 9 (11:59pm MST)! Apply for a scholarship or submit a short talk for Keystone Symposium on Fueling MASH this April. Join top researchers on MASH/NASH, liver metabolism & fibrosis. 🔗 Register: keysym.us/KSMASH26 @dnachicken.bsky.social #KSMASH26 #LiverDisease #KeystoneSymposia

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Jennifer Estall @dnachicken.bsky.social · 27/09/2025

You are exactly right! More works needed to understand how all these diets change your physiology. Thank you!

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Jennifer Estall @dnachicken.bsky.social · 27/09/2025

Weight loss is generally associated with reduced liver fat. So if IF leads to weight loss in someone, likely their total liver fat has gone down too. It would be interesting to see long term if persistent fasting hormones reprogram the fasting response in liver.

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Jennifer Estall @dnachicken.bsky.social · 27/09/2025

I think there’s a lot we still need to know. Is glucagon signaling persistent in IF and does it desensitize? How do other fasting hormones factor in (like cortisol and adrenaline). I would love to see a longitudinal study on liver fat changes over the course of different IF protocols.

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Jennifer Estall @dnachicken.bsky.social · 26/09/2025

This research is the result of over 10 years of work, numerous collaborations and the tireless efforts of many people in my lab. Thank you to everyone!! In particular, first author Dr Aysim Gunes, and Clemence Schmitt whose talents allow us to tell our story in pictures. 6/6

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Jennifer Estall @dnachicken.bsky.social · 26/09/2025

In mice, high PGC-1A4 causes accumulation of large lipid droplets, drives a MASLD-like lipid signature, and worsens liver disease with a western diet. In people living with MASLD, high levels of PGC-1A4 in liver correlate with more steatosis and larger lipid droplets. 5/6

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Jennifer Estall @dnachicken.bsky.social · 26/09/2025

Fasting increases PPARγ levels in liver, facilitating lipid uptake and allowing lipid droplets to expand by increasing levels of Fsp27/Cidec. 4/6

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Jennifer Estall @dnachicken.bsky.social · 26/09/2025

How does the liver know when to burn or store? We found this is driven by glucagon and PPARγ, and coordinated by the PGC-1A family of co-activators. One family member (PGG-1A1) drives lipid catabolism, while another (PGC-1A4) promotes lipid storage, at different times. 3/6

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Jennifer Estall @dnachicken.bsky.social · 26/09/2025

Why is this important? The liver burns lipids during fasting for energy. But the liver accumulates fat during fasting, which may seem paradoxical. The lipids it stores are needed when other energy sources become scarce, especially if the fast goes on for a long time. 2/6

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Jennifer Estall @dnachicken.bsky.social · 24/09/2025

Just thought I would share this recent study in 2.5M children, if people want to see some of the research. Spoiler: No association was found. Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability url: jamanetwork.com/journals/jam...

jamanetwork.com

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

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Reposted by Jennifer Estall

CIRTN-R2FIC @cirtn.bsky.social · 15/09/2025

🧵(3/3) Cont' beginning of Sept 2025: 1) www.cell.com/cell-stem-ce... 2) academic.oup.com/edrv/advance... 3) www.nature.com/articles/s41...

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Reposted by Jennifer Estall

CIRTN-R2FIC @cirtn.bsky.social · 15/09/2025

🧵(2/3) Cont' beginning of Sept 2025: 2) “Glycerol and glycerol-3-phosphate: multifaceted metabolites in metabolism, cancer and other diseases” PMID: 40927981 3) “Osteocalcin has many tricks to get γ-carboxylated” PMID: 40913186 Links in last thread

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Reposted by Jennifer Estall

CIRTN-R2FIC @cirtn.bsky.social · 15/09/2025

🧵(1/3) Our first post highlighting publications coming from CIRTN groups (first half of September 2025)! We have works from the labs of Drs. Marc Prentki, Timothy Kieffer and Mathieu Ferron. 1)“From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony” PMID 40912231

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Jennifer Estall @dnachicken.bsky.social · 11/04/2025

An amazing line up, as always! This is a highly recommended conference for anyone in metabolism.

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