iiinova — where your digital self keeps evolving

Dinler Antunes @dinler.bsky.social · 20/06/2026

The #AntunesLab at @uh.edu is actively working on new methods and tools for advancing the design of better and safer cancer immunotherapies. #NCI, #ITCR, #CIP-Net, #HEALTH-RCMI, @itcrtraining.bsky.social

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Dinler Antunes @dinler.bsky.social · 20/06/2026

We conclude that TCR-focused computational approaches are becoming a central pillar of precision immuno-oncology, but realizing their full potential will require tighter integration of experimental and computational methods, larger datasets, and shared community standards.

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Dinler Antunes @dinler.bsky.social · 20/06/2026

AI is having a major impact on the field, particularly in structural modeling and specificity prediction. At the same time, many of the key bottlenecks remain biological: limited ground-truth datasets, TCR cross-reactivity, benchmarking, and generalization to unseen antigens.

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Dinler Antunes @dinler.bsky.social · 20/06/2026

One major challenge is that TCR analysis is no longer just a sequencing problem. Understanding T-cell responses increasingly requires integrating repertoire sequencing, structural biology, antigen specificity, and clinical data into a coherent framework.

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Dinler Antunes @dinler.bsky.social · 20/06/2026

We reviewed 40+ computational tools and organized them into a unified workflow for TCR analysis: • Data acquisition • TCR reconstruction & inference • Clustering • Structural modeling • Specificity prediction • Clinical integration

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Dinler Antunes @dinler.bsky.social · 20/06/2026

The idea and opportunity to write this review came after a I was invited to participate in the @sitcancer.bsky.social panel “Leveraging the Power of Artificial Intelligence to Foster Progress in Immuno-oncology.”

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Dinler Antunes @dinler.bsky.social · 20/06/2026

Excited to share our invited review on computational TCR analysis, now published in #JITC. Huge thanks to my lab and collaborators, especially #PamellaBorges, who led this huge effort. 🧵 A few thoughts on our journey and the landscape today: jitc.bmj.com/content/14/6...

jitc.bmj.com

Mapping the TCR landscape: computational tools empowering translational immunology and therapy design

T cell receptors (TCRs) are central to adaptive immunity, yet their vast sequence and structural diversity present a significant challenge to fully understand immune responses. The application of high...

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Dinler Antunes @dinler.bsky.social · 20/06/2026

Fun development: This panel participation @sitcancer.bsky.social led to an invited review paper on mapping the computational landscape for TCR analysis, which is now online at #JITC. Big thanks to my trainee Pamela Borges, who led the effort, and all the co-authors. jitc.bmj.com/content/14/6...

jitc.bmj.com

Mapping the TCR landscape: computational tools empowering translational immunology and therapy design

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Dinler Antunes @dinler.bsky.social · 13/03/2026

Paper: www.nature.com/articles/s41... GitHub: github.com/AntunesLab/r... RMSX + Flipbook connect time → residue → structure, compatible with GROMACS, NAMD, AMBER and OpenMM.

nature.com

High resolution mapping of protein motions in time and space with RMSX and Flipbook - Scientific Reports

Scientific Reports - High resolution mapping of protein motions in time and space with RMSX and Flipbook

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Dinler Antunes @dinler.bsky.social · 13/03/2026

Research @uh.edu Work by @finnberuldsen.bsky.social at #AntunesLab @uh.edu led to the development of RMSX + Flipbook for time-resolved MD trajectory analysis. Watch a quick walkthrough of the tools 👇 See how residue-level motion evolves over time. www.youtube.com/watch?v=UoN0...

youtube.com

Visualizing Protein Motion in MD: Beyond RMSD & RMSF

YouTube video by Finn Beruldsen

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Dinler Antunes @dinler.bsky.social · 12/03/2026

Ever seen an RMSD spike in a molecular dynamics simulation and wondered: What actually moved? Which residues? Our new @springernature.com paper introduces RMSX + Flipbook for time-resolved MD trajectory analysis 👇 #MolecularDynamics #ComputationalChemistry #ScientificPython #OpenScience

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Dinler Antunes @dinler.bsky.social · 11/11/2025

We had a very productive week at the 40th @sitcancer.bsky.social 2025 meeting. Learned a lot from experts sharing cutting-edge research in immunotherapy, and loved to see my team engaging with attendees from all over the globe. #AntunesLab @uh.edu

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Dinler Antunes @dinler.bsky.social · 08/11/2025

Had a great time discussing AI advances in TCR modeling @sitcancer.bsky.social

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Reposted by Dinler Antunes

University of Houston @uh.edu · 22/03/2025

Winning isn’t just happening on the court — UH’s rise to become one of Forbes’ top 50 public universities proves our momentum is unstoppable. Read more: www.uh.edu/news-events/...

Cullen Performance Hall with UH banner. Text reads, “UH Scores Big in Forbes’ 2025 Rankings of Top 50 Public Universities.”

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Reposted by Dinler Antunes

Jeremy Berg @jeremymberg.bsky.social · 15/03/2025

DASHBOARD (Yellow are fields with known data sources, gray are fields that would need to be crowd sourced). Comments and suggestions welcome!

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Reposted by Dinler Antunes

Jeremy Berg @jeremymberg.bsky.social · 24/02/2025

IMPORTANT Collecting data to understand and strengthen arguments about the impact of the administration's ill-considered actions and the responses of universities... Please share!

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