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Mitochondrial function varies widely across kidney nephron segments, yet conventional approaches lack the resolution and control needed to assess cell-type-specific bioenergetics in situ. We present a...

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From harnessing early-life microbes to protect against diabetes, to targeting cardiac metabolism in heart failure, a new hub is proving that metabolism is a common thread across diseases, and the next frontier in biomedical discovery.

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The authors show that mitochondria can chronically hyperpolarize under normal or disease conditions and be induced by environmental exposures. This triggers phospholipid remodeling, which in turn affe...