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David M. Versluis

@davidversluis.bsky.social
56 followers 56 following 5 posts

Research fellow in modelling and experimental analysis of immune cell migration at University College London 🏳️‍🌈

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David M. Versluis @davidversluis.bsky.social · 07/10/2026
We think this may have implications for many systems with migrating cells. Autoattractants can be very useful in migration, but because they work best when short-lived they will also be hard to find in experiments, and so may exist in many more systems than previously believed.
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David M. Versluis @davidversluis.bsky.social · 07/10/2026
Finally, we show how in slow-moving cells (think macrophages) a decaying autoattractant can lead to a variety of different outcomes, from clumping to leader-follower, and how a close association just shy of clumping causes the best chemotaxis.
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David M. Versluis @davidversluis.bsky.social · 07/10/2026
Next, we show how a decaying autoattractant can be much more robust than a broken down autoattractant.
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David M. Versluis @davidversluis.bsky.social · 07/10/2026
We have the simulated immune cells migrate along a self-generated gradient, and produce an autoattractant in ratio to the attractant destroyed. First, we show that autoattractant must both be made and broken down to function and that saturable receptors lead to optimal autoattractant lifetimes.
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David M. Versluis @davidversluis.bsky.social · 07/10/2026
I have a new paper out: Communication through autoattractants can enhance and limit collective migration of immune cells journals.plos.org/ploscompbiol... We show how complex interactions emerge around a secreted attractant, and you can play with the model online: chemotaxis.org/autoattracta...
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Reposted by David M. Versluis
Robert Insall @robinsall.bsky.social · 03/04/2026
New paper! Self-generated gradients in macrophage chemotaxis. Just published, by the esteemed Abhi Kiran and many collaborators. A short skytorial follows. journals.plos.org/plosbiology/...
journals.plos.org
Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a
Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. This study shows that macrophages ...
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