iiinova — where your digital self keeps evolving

David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 09/06/2026

@lifebiosciences has confirmed the first patient has been dosed with an epigenetic restoration drug candidate. Exciting milestone 🚀 Life Biosciences is the OG cellular rejuvenation company, using epigenetic restoration to reverse diseases of aging lifebiosciences.com/life-bioscie...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/04/2026

From 2008-2024 I was accused of hyping (a common slur) for suggesting that changes to the epigenome might cause aging and that therapeutics could "allow us to reset the epigenome to a more youthful state." - Oberdoerffer & Sinclair (2009) Success has many fathers, while failure is an orphan

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 23/04/2026

Higher omega-3 levels are linked to ~15–20% lower mortality risk. More here: www.nature.com/articles/s41...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 14/04/2026

Are annoying age spots due to epigenetic drift, a likely cause of aging? "Consistent with the Information Theory of Aging, we found a global disruption of tight epigenetic regulation"...at genes involved in DNA repair, inflammation & mitochondria Fascinating! link.springer.com/article/10.1...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 08/04/2026

Large meta-analysis of ultra-processed food intake is linked to multiple chronic diseases, not just obesity www.bmj.com/content/384/...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 08/03/2026

NEW STUDY: Osteoarthritis and back pain affect millions. Instead of merely managing symptoms, envision reversing the age of joints A new study reveals that reprogramming gene combo OSK can regrow joints in mice - effects are dependent on TET2, so it epigenetic www.nature.com/articles/s12...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 31/01/2026

Decline is optional longer than most people think. Just ask my perfectly healthy 86 year-old father 💪

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 29/01/2026

Proud of the Life Biosciences team! Michael, Sharon and Jerry. Onward!

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/01/2026

Muscle mass predicts survival better than BMI in older adults www.sciencedirect.com/science/arti...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 18/01/2026

Trametinib is an approved drug for melanoma. It inhibits MEK1/2 thereby shifting cells away from “grow at all costs” to maintenance & repair🐁Trimetaprib extends lifespan ~15% & with rapamycin a whopping 30%

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 29/12/2025

Scientific misinformation is rampant. Journals known as "paper mills" are profiting by charging academics to quickly publish low quality or fraudulent work, which is then hyped on social media or disseminated for profit to the unsuspecting public by deepfaked scientists on YouTube & TikTok

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 26/12/2025

One of the most rewarding things is inspiring a talented student to work on a problem that initially seems impossible

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 23/12/2025

Up to 40% of drugs that would work in humans fail in mice & are therefore never developed. But mice aren’t humans In aging research, one government-sanctioned single mouse breed lifespan test can kill future funding, even for a promising therapy That’s politics, not science

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 15/12/2025

Pancreatic cancer has a 5-year survival of 13% often driven by KRASG12D mutations New paper shows KRASG12D suppresses SIRT3 & forced SIRT3 expression inhibits cancer in mice Could SIRT3 boosters (e.g. NMN & NR) prevent pancreatic cancer or treat patients? www.jbc.org/article/S002...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 29/11/2025

The ITOA paper from 2023, in which Michael played a seminal role, not just in generating data, but keeping the team and especially the young students motivated, despite the difficulty of the decade-long project and the harsh scientific critics of the day. R.I.P. Michael 🍻🙏🧎

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 29/11/2025

Five years ago today, our dear friend and colleague Michael Bonkowski passed away unexpectedly. For a decade, he was the life of the Sinclair lab, a major force testing The Information Theory of Aging & cared so deeply about his students they still speak of him like a father🙏

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 26/11/2025

Patent granted! “Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“ Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 08/11/2025

RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏

Jim Watson and me at his office at Cold spring Harbor

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 16/10/2025

Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 16/10/2025

This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 16/10/2025

Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 26/08/2025

With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 26/08/2025

In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 26/08/2025

This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 16/05/2025

All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 06/05/2025

Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏 @biorxivpreprint.bsky.social @volofoundation.bsky.social tinyurl.com/544kzccz

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/03/2025

Link to the review: link.springer.com/article/10.1...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/03/2025

Where to get polyphenols? From berries, apples with skin, cherries, plums, pomegranates, spinach, red onions, artichokes, broccoli, asparagus, matcha green tea, black tea, coffee, dark chocolate, turmeric, beans, EVOO and any deeply-colored vegetable

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/03/2025

The authors of this new review discuss how polyphenols like curcumin, quercetin, resveratrol, and genistein seems to also target cancer-related miRNAs, thereby slowing cancer progression...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/03/2025

In the 1990s, Victor Ambros and Gary Ruvkun (in my Department @harvardmed.bsky.social) were interested in how different cell types develop in worms. They discovered microRNA, a new class of tiny RNA molecules that regulate genes called miRNAs...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/03/2025

In the 1990's, antioxidants were all the rage. Today, we know so much more, while the food and beverage industry still promotes antioxidants as though they were the most important thing...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 24/03/2025

Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 04/02/2025

Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏 t.co/XGexiZFQg3

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

I couldn’t be prouder of the Sinclair lab family, now over 200 amazing people 🥹

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

Haim showed that the human SIRT1 gene is activated by CR, which protects cells (Science), Dudley showed all yeast Sirtuins mediate CR (Science) & Joe showed activators improve 🐁 health (Nature)

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

Roz showed adversity turns on NAD biosynthetic gene to extend lifespan (Nature), Kevin & Jason showed Sirtuins can be activated by molecules (Nature & Science)…

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

In the first 5 years, Kevin & Roz showed Sirtuins are regulated by B3 and NAD availability (in Science)…

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

but we didn’t know how epigenetics was related to aging, why the epigenome changed over time, if aging was reversible, how the environment influenced Sirtuin activity, or if any of this was relevant to humans

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

In those days, we barely knew anything about aging. The Sirtuins had just been linked to yeast aging (in the Guarente lab @mit where I’d moved from)…

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 03/02/2025

Our lab is 25 years old this week. A big thanks to past and present lab members who’ve work so hard to make the world a better place 🙏 🙏 🙏 Some photos and milestones 🧵

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 30/01/2025

In 2024, spermidine at 40 mg/day had minimal effects on circulating spermidine in older men & with no significant changes in lipids or blood biomarkers compared to placebo, though the trial was only 28 days

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 30/01/2025

A recent study of mice and people showed that spermidine modifies RIPK1 to block inflammation and protect against type 2 diabetes and vascular damage nature.com/articles/s41...

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 30/01/2025

In honey bees, spermidine causes profound epigenetic changes and autophagy, contributing to increased honey bee lifespan

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 30/01/2025

The best documented lifespan extension due to spermidine was in fruit flies, which increased 30% In worms & yeast, extension was around 15–25% In mice, there is up to 25% extension of mean lifespan, with lifelong administration

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David A. Sinclair, Ph.D. @davidsinclairphd.bsky.social · 30/01/2025

Spermidine increases human hair growth in vitro, and up-regulates epithelial stem cell markers, keratins K15 and K19

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