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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

10/11 These findings have exciting implications for brain stimulation therapies in psychiatry and neurology. Targeting high-order vs low-order networks might require completely different stimulation approaches!

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

9/11 As @DanteSommoPoeta wrote: "The more perfect a thing is, the more it feels." In the brain, like basketball, star players like @Lebron James (cognitive networks) react dramatically to game changes while role players (sensory networks) maintain steadier, independent performance.

media.tenor.com

lebron james is wearing a yellow lakers jersey with the number 23

ALT: lebron james is wearing a yellow lakers jersey with the number 23

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

8/11 Meanwhile, low-order sensory networks were barely affected by removing these feedback connections! Their responses remained strong, suggesting they rely mostly on local processing rather than whole-brain feedback.

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

7/11 The results were striking: high-order networks NEED feedback from the rest of the brain to generate their full response. When we cut these feedback connections, their responses were significantly reduced.

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

6/11 But why? To understand the mechanism, we built computational models of each patient's brain based on their anatomical connections, and then performed "virtual dissections" - selectively removing connections between networks.

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

5/11 We discovered an "excitability gradient" across the brain! High-order cognitive networks (like the Default Mode Network) showed much stronger responses to stimulation than low-order sensory networks.

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

4/11 Based on our previous computational modeling work (elifesciences.org/articles/83232), we used rare data from 36 epilepsy patients, recording brain activity during 323 electrical stimulation sessions. This gave us a unique window into how stimulation activates different brain regions!

elifesciences.org

TMS-evoked responses are driven by recurrent large-scale network dynamics

Whole-brain computational modelling, incorporating novel ML-based parameter estimation techniques, reveals how transcranial magnetic stimulation-evoked brain responses are driven at earlier timepoints...

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

3/11 Building on @Daniel S. Margulies' seminal work on the "principal gradient" of brain organization (pnas.org/doi/10.1073/...), we asked how these different networks respond to direct electrical stimulation.

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

2/11 The human brain has a fascinating organization: from simple sensory regions to complex cognitive networks. We wondered: do these different networks respond differently when stimulated? And does this follow the brain's known hierarchical organization? academic.oup.com/brain/articl...

academic.oup.com

From sensation to cognition.

Abstract. Sensory information undergoes extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cogniti

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davemomi.bsky.social @davemomi.bsky.social · 05/04/2025

1/11 How does our brain's hierarchical organization impact its response to stimulation? We found striking differences between "high-order" networks (involved in complex cognition) vs "low-order" networks (handling sensory/motor functions) @naturecomms.bsky.social www.nature.com/articles/s41...

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davemomi.bsky.social @davemomi.bsky.social · 09/03/2025

My school in Tanzania is running well! The Giona Basketball Academy just hosted a U12–U19 tournament last week—so much fun! Want to join me in Tanzania, explore the country, and make an impact at my school? DM me! #FreeEducation #SportsValue #Basketball #Tanzania

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davemomi.bsky.social @davemomi.bsky.social · 24/02/2025

🚀 @GiovanniRabuffo is presenting our poster "Large-Scale Neural Dynamics as a Predictor of Stimulus Effects" at the 6th #BrainStimConf! 📍 Poster P2.064 Don't miss it—come discuss our latest findings on neural dynamics and stimulation effects! #BrainStimulation #Neuroscience

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davemomi.bsky.social @davemomi.bsky.social · 19/02/2025

Excited to attend Brain Stimulation Conference! Presenting 3 talks and chairing the symposium on Computational and Mathematical Models of Brain Stimulation-Induced Synaptic Plasticity. Looking forward to great discussions and connecting with this amazing community! #BrainStimConf

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davemomi.bsky.social @davemomi.bsky.social · 11/02/2025

Truly honored and grateful that our symposium Advancements in Brain Stimulation Modeling has been accepted for #OHBM2025 marking our third time being part of this incredible event. Heartfelt thanks to the @ohbmofficial.bsky.social community for this opportunity! #BrainStimulation #modelling

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davemomi.bsky.social @davemomi.bsky.social · 29/01/2025

🎉 Thrilled to announce that our course on Neural Field Theory & Brain Networks has been accepted for #OHBM2025! Third year teaching computational neuroscience at OHBM. Can't wait to explore brain dynamics in Brisbane! @ohbmtrainees.bsky.social @drbreaky.bsky.social @johndgriffiths.bsky.social

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