Abstract. Background: Genetic variants causing diseases with hypertension as a secondary feature have previously been identified. Studies focussing on primary hypertension have utilised common and lat...

Abstract. Introduction Previous studies have demonstrated effects of rare coding variants on common, clinically relevant phenotypes although the additive burden of these variants makes only a small co...

With a population prevalence of 1%, schizophrenia is widespread, yet the aetiology of this psychiatric disorder remains elusive. There is an evident genetic component of schizophrenia, with heritabili...

With a population prevalence of 1%, schizophrenia is widespread, yet the aetiology of this psychiatric disorder remains elusive. There is an evident genetic component of schizophrenia, with heritabili...

The Suffolk MP spent a month in hospital in 2018 and had to rebuild "aspects" of her memory.

David Curtis explores findings from a previous study, utilizing an expanded sample of 470,000 exome-sequenced individuals. The aim was to identify genes linked to type 2 diabetes (T2D) and examine the...

Abstract. Introduction: A previous study of 200,000 exome-sequenced UK Biobank participants to test for association of rare coding variants with hypertension implicated two genes at exome-wide signifi...

medRxiv - The Preprint Server for Health Sciences

Rooting out manipulation should not depend on dedicated amateurs who take personal legal risks for the greater good

State health officials will consider adding genomic sequencing to the mandatory baby blood testing hospitals do to test for disease.

Identification of specific genes involved in schizophrenia aetiology – what difference does it make? - Volume 221 Issue 2

The General Medical Council says efforts to recruit more UK doctors will take years to take effect.

Abstract. Our intuitive concept of the relations between brain and mind is increasingly challenged by the scientific world view. Yet, although few neuroscientists openly endorse Cartesian dualism, car...

There are comments on PubPeer for publication: Identification of circulating proteins associated with general cognitive function among middle-aged and older adults (2023)

We need less research, better research, and research done for the right reasons What should we think about a doctor who uses the wrong treatment, either wilfully or through ignorance, or who uses the...

Missense variants that alter a single amino acid in the encoded protein contribute to many human dis

Figure is 42% higher than previous estimates and would pose ‘enormous threat’ to healthcare systems

The mechanistic tie between genome-wide association study (GWAS)-implicated risk variants and disease-relevant cellular phenotypes remains largely unk…