ajicjournal.org
Cluster of Extensively Drug-Resistant Shigella sonnei Carrying blaCTX-M-15 in Los Angeles, California, 2023-2024
We describe 3 cases of extensively drug-resistant (XDR) Shigella sonnei infections among men who have sex with men (MSM) in Los Angeles, CA. Using whole-genome sequencing, we determined that they are highly genetically related, exhibit similar antimicrobial resistomes, and appear to be distinct from other circulating strains. These cases highlight the rapid expansion of XDR Shigella in the U.S. and urgent need for appropriate detection and management.