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Danny

@dannybar.bsky.social

65 followers 8 following 9 posts

Molecular biology of aging at Tel Aviv University. DanielBar.eth

Posts Replies Media

Danny @dannybar.bsky.social · 02/07/2025

Our ChAMP paper is out! epigeneticsandchromatin.biomedcentral.com/articles/10....

epigeneticsandchromatin.biomedcentral.com

Detecting Protein-DNA binding in single molecules using antibody guided methylation - Epigenetics & Chromatin

Characterization of DNA binding sites for specific proteins is of fundamental importance in molecular biology. It is commonly addressed experimentally by chromatin immunoprecipitation and sequencing (...

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Danny @dannybar.bsky.social · 14/06/2025

information loss in the liver. Thanks to the Goldstein lab that provided much of the data and the ChIP-seq analysis. biorxiv.org/content/10.1... P.S. the preprint isn't really new, but you aren't following me on twitter, so it's new for you.

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Danny @dannybar.bsky.social · 14/06/2025

and some diseases. Here, we show that these sites causally contribute to aging: both pathogenic SNPs and causal epigenetic clocks (DamAge) are enriched for these sites. Information loss is also reversible: in mice, repeated fasting (but not a single fast) reverses this 2/3

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Danny @dannybar.bsky.social · 14/06/2025

Our preprint "Reversible and Causal Epigenetic Information Loss in Liver Aging and Disease" is out! We've previously shown that looking at methylation sites that are very different in one tissue from all others allows us to observe epigenetic information is loss upon aging 1/3

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Danny @dannybar.bsky.social · 13/06/2025

open.spotify.com/playlist/1As...