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Dan Isom

@danisomlab.bsky.social
281 followers 506 following 32 posts

University of Miami, FL: molecular and cellular basis of proton sensing, synBio for health/energy and drug discovery, novel data science for protein structure-function informatics, and AI: www.isomlab.com

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Dan Isom @danisomlab.bsky.social · 10/05/2026
www.biorxiv.org/content/10.6...
biorxiv.org
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Dan Isom @danisomlab.bsky.social · 06/12/2025
Grateful to our organizers—@danisomlab, Jennifer Arcuri, and Kerry Burnstein—and to everyone who made the retreat such a success. Here’s to the next chapter. 🌴🔬
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Dan Isom @danisomlab.bsky.social · 06/12/2025
The result: new collaborations, new ideas, and a stronger sense of departmental community than ever. The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward.
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Dan Isom @danisomlab.bsky.social · 06/12/2025
We just wrapped up the 7th Molecular & Cellular Pharmacology Retreat in the Florida Keys, and the energy was incredible. Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work.
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Dan Isom @danisomlab.bsky.social · 29/11/2025
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry www.jbc.org/article/S002...
jbc.org
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators
Periplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present PIONEER, a modular platform that localizes peptides, prote...
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Dan Isom @danisomlab.bsky.social · 13/01/2025
Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...
dolphinscancerchallenge.com
Help me Challenge Cancer!
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTe...
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Dan Isom @danisomlab.bsky.social · 03/01/2025
These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did
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Dan Isom @danisomlab.bsky.social · 03/01/2025
There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.
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Dan Isom @danisomlab.bsky.social · 03/01/2025
"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation."
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Dan Isom @danisomlab.bsky.social · 22/12/2024
I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab: tinyurl.com/Pap-Corps-EC...
tinyurl.com
URL Shortener, Branded Short Links & Analytics | TinyURL
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Dan Isom @danisomlab.bsky.social · 16/12/2024
Thanks Nina!
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Dan Isom @danisomlab.bsky.social · 16/12/2024
miami.zoom.us/webinar/regi...
miami.zoom.us
Welcome! You are invited to join a webinar: The Pap Corps Champions for Cancer Research Endowed Chair. After registering, you will receive a confirmation email about joining the webinar.
Chair ceremony for Dr. Daniel G. Isom
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Dan Isom @danisomlab.bsky.social · 29/11/2024
The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget.
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Dan Isom @danisomlab.bsky.social · 27/11/2024
Happy Thanksgiving from Miami.
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Dan Isom @danisomlab.bsky.social · 14/11/2024
Yay Defne! news.med.miami.edu/can-a-diabet...
news.med.miami.edu
Can a Diabetes Drug and Immunotherapy Help Treat Brain Cancer? - InventUM
Defne Bayik, Ph.D., is pioneering new treatments to find combination therapies that may help T-cell response against glioblastoma.
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Dan Isom @danisomlab.bsky.social · 13/11/2024
In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂
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Dan Isom @danisomlab.bsky.social · 15/09/2024
Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology. tinyurl.com/2p88y72h
tinyurl.com
Advances in yeast synthetic biology for human G protein–coupled receptor biology and pharmacology
G protein–coupled receptors (GPCRs) are the largest family of transmembrane receptors in humans. Over 800 GPCRs regulate the (patho)biology of every o…
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Dan Isom @danisomlab.bsky.social · 06/12/2023
What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6
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Dan Isom @danisomlab.bsky.social · 10/11/2023
Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer...
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Dan Isom @danisomlab.bsky.social · 16/09/2023
Chicagoland.
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Dan Isom @danisomlab.bsky.social · 23/08/2023
SUP on Lake Tahoe today:
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Dan Isom @danisomlab.bsky.social · 20/08/2023
Happy to be among this fine assembly of protonators: www.biophysics.org/2023tahoe-proton…
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Dan Isom @danisomlab.bsky.social · 19/08/2023
Sugar gold.
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Dan Isom @danisomlab.bsky.social · 19/08/2023
I would.
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Dan Isom @danisomlab.bsky.social · 19/08/2023
That bill is strangely pleasing.
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Dan Isom @danisomlab.bsky.social · 19/08/2023
Wow, SoCal feeling SoFlo.
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Dan Isom @danisomlab.bsky.social · 19/08/2023
Otterly astounding ;)
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Dan Isom @danisomlab.bsky.social · 19/08/2023
Love the graphic.
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Dan Isom @danisomlab.bsky.social · 18/08/2023
PIEZO1 action up close: www.nature.com/articles/s41586-023-…
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Dan Isom @danisomlab.bsky.social · 18/08/2023
Cool, but SUPER TINY proteins: www.nature.com/articles/s41586-023-…
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Dan Isom @danisomlab.bsky.social · 17/08/2023
I share your whoa!
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Dan Isom @danisomlab.bsky.social · 17/08/2023
STING may be a proton channel: www.science.org/doi/10.1126/science…
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