Dan Isom @danisomlab.bsky.social · 06/12/2025Grateful to our organizers—@danisomlab, Jennifer Arcuri, and Kerry Burnstein—and to everyone who made the retreat such a success. Here’s to the next chapter. 🌴🔬 000
Dan Isom @danisomlab.bsky.social · 06/12/2025The result: new collaborations, new ideas, and a stronger sense of departmental community than ever. The takeaway is clear—our science is cutting-edge, and bringing people together like this is essential for moving both individual and team discoveries forward. 100
Dan Isom @danisomlab.bsky.social · 06/12/2025We just wrapped up the 7th Molecular & Cellular Pharmacology Retreat in the Florida Keys, and the energy was incredible. Under the theme “Colab in the Cays,” scientists from 15+ labs shared 53 talks across two days, with every single participant presenting their work. 121
Dan Isom @danisomlab.bsky.social · 29/11/2025PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry www.jbc.org/article/S002...jbc.orgPIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein RegulatorsPeriplasmic display in yeast is a promising but underdeveloped method for screening and studying genetically encoded biomolecules. We present PIONEER, a modular platform that localizes peptides, prote... 041
Dan Isom @danisomlab.bsky.social · 13/01/2025Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...dolphinscancerchallenge.comHelp me Challenge Cancer!The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTe... 020
Dan Isom @danisomlab.bsky.social · 03/01/2025These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did 000
Dan Isom @danisomlab.bsky.social · 03/01/2025There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations. 100
Dan Isom @danisomlab.bsky.social · 03/01/2025"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation." 100
Dan Isom @danisomlab.bsky.social · 22/12/2024I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab: tinyurl.com/Pap-Corps-EC...tinyurl.comURL Shortener, Branded Short Links & Analytics | TinyURL 010
Dan Isom @danisomlab.bsky.social · 16/12/2024miami.zoom.us/webinar/regi...miami.zoom.usWelcome! You are invited to join a webinar: The Pap Corps Champions for Cancer Research Endowed Chair. After registering, you will receive a confirmation email about joining the webinar.Chair ceremony for Dr. Daniel G. Isom 130
Dan Isom @danisomlab.bsky.social · 29/11/2024The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget. 030
Dan Isom @danisomlab.bsky.social · 14/11/2024Yay Defne! news.med.miami.edu/can-a-diabet...news.med.miami.eduCan a Diabetes Drug and Immunotherapy Help Treat Brain Cancer? - InventUMDefne Bayik, Ph.D., is pioneering new treatments to find combination therapies that may help T-cell response against glioblastoma. 000
Dan Isom @danisomlab.bsky.social · 13/11/2024In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂 010
Dan Isom @danisomlab.bsky.social · 15/09/2024Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology. tinyurl.com/2p88y72htinyurl.comAdvances in yeast synthetic biology for human G protein–coupled receptor biology and pharmacologyG protein–coupled receptors (GPCRs) are the largest family of transmembrane receptors in humans. Over 800 GPCRs regulate the (patho)biology of every o… 011
Dan Isom @danisomlab.bsky.social · 06/12/2023What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6 000
Dan Isom @danisomlab.bsky.social · 10/11/2023Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer... 000
Dan Isom @danisomlab.bsky.social · 20/08/2023Happy to be among this fine assembly of protonators: www.biophysics.org/2023tahoe-proton… 000
Dan Isom @danisomlab.bsky.social · 18/08/2023PIEZO1 action up close: www.nature.com/articles/s41586-023-… 143
Dan Isom @danisomlab.bsky.social · 18/08/2023Cool, but SUPER TINY proteins: www.nature.com/articles/s41586-023-… 000
Dan Isom @danisomlab.bsky.social · 17/08/2023STING may be a proton channel: www.science.org/doi/10.1126/science… 130