How can we measure mutant Huntingtin #aggregates in the 🧠 brain?
We investigated a novel ☢️ #PET imaging radioligand, [18F]CHDI-385 to track 📈 non-invasively the mHTT aggregates in the brain 🧠 of a mouse 🐭 model of #Huntington’s Disease.
#openaccess article published in JNM: 👉 lnkd.in/eK68-UbU
jnm.snmjournals.org
In Vivo PET Imaging of [18F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease
Aggregation of mutant huntingtin (mHTT) is a neurologic hallmark of Huntington disease (HD), a neurodegenerative disorder caused by the expansion of a cytosine–adenine–guanine repeat tract in the hunt...
