iiinova — where your digital self keeps evolving

Derek Mann @damann1.bsky.social · 18/11/2025

Very proud of our latest review on the challenges of surgical treatments for hepatocellular carcinoma

Derek Mann @damann1.bsky.social · 06/07/2025

As Newcastle University’s Professor of Hepatology, I am honoured and extremely proud to be a contributor to its world top 10 ranking in Gastroenterology and Hepatology 👊

270

Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · 16/06/2025

The NU Conference was a big success with a superb plenary from Ram DasGupta (CRUK Scotland). Prizes for talks - J Dishington (1st) and H Stewart; flash talks - E Woodward (1st), L Taylor (2nd); posters - E Hackney (1st), K Papa (2nd). Congrats and to all presenters for giving us a memorable day!

001

Derek Mann @damann1.bsky.social · 22/04/2025

Spectacular 3 days in Singapore. Everyone should visit

230

Derek Mann @damann1.bsky.social · 27/03/2025

Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease

043

Derek Mann @damann1.bsky.social · 14/03/2025

Our latest paper, published today in FEBS Letters is a chemical biology study on development of drugs selectively targeting HDAC6 with demonstration of efficacy in a human model of liver fibrosis. febs.onlinelibrary.wiley.com/doi/10.1111/...

febs.onlinelibrary.wiley.com

FEBS Press

Chronic liver injury can lead to severe conditions such as cirrhosis and liver cancer. Unfortunately, there are no effective treatments to halt or reverse liver fibrosis, which makes new therapeutic ....

032

Derek Mann @damann1.bsky.social · 27/02/2025

Wow, phenomenal work. 75% of pancreatic cancer patients alive 3 years after receiving a personalised mRNA vaccine. Durable CD8+ T cell responses underlying the therapeutic benefit. Congrats to the authors 👊👏 www.nature.com/articles/s41...

nature.com

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature

In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...

0104

Derek Mann @damann1.bsky.social · 21/02/2025

Dr Amy Collins from our group and @nucancer.bsky.social selected for early career researcher oral presentation of her poster on use of a complex human tissue culture model of liver cancer for drug development.

010

Derek Mann @damann1.bsky.social · 20/02/2025

Next up, our talented PhD student Keara, who was super busy at her poster on development of a tumour slice screening platform for discovery of liver cancer drug targets.

051

Derek Mann @damann1.bsky.social · 20/02/2025

Dr Amy Collins is busy at her poster on modelling hepatocellular carcinoma at the 2025 EASL Liver Cancer Summit in Paris. Funding for her work from Cancer Research U.K.

042

Derek Mann @damann1.bsky.social · 11/02/2025

Well done Keara, very proud of you!

020

Derek Mann @damann1.bsky.social · 04/02/2025

On World Cancer Day we welcome Dr Abdullah Malik to our liver cancer team. Abdullah is a talented surgeon who has won a prestigious Medical Research Council clinician scientist training fellowship to research the basis of recurrence of cancer following surgical removal of a patient’s tumour.

040

Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · 04/02/2025

Today is World Cancer Day. At the NU Centre for Cancer we are dedicated to working towards more effective and gentler treatments for cancer patients.

054

Derek Mann @damann1.bsky.social · 10/01/2025

In addition to my trials and tribulations with bowel cancer I also suffer from pre-cancerous lesions on the skin around my eyes. So now have a new pair of wraparound prescription shades to offer a better degree of protection. Not sure if I look more like The Terminator or a character from The Matrix

330

Reposted by Derek Mann

Newcastle University Centre for Cancer @nucancer.bsky.social · 02/01/2025

We are very proud that our very own Professor Christine Harrison has been deservedly recognised with an OBE for her work on improving the scientific knowledge and care of childhood leukaemia. bloodcancer.org.uk/news/blood-c...

bloodcancer.org.uk

Blood Cancer UK | Blood cancer researcher recognised in King’s New Years Honours

The King’s New Years Honours list has been announced with Blood Cancer UK's trustee awarded an OBE for services to children.

031

Derek Mann @damann1.bsky.social · 18/12/2024

Our brain is not a computer “Why does the brain need billions of neurons to process 10bits/sec? Why can we only think about one thing at a time?” Fascinating paper makes me wonder if aspects of neurodivergence (e.g. ADHD) are the brain trying to be a little faster? arxiv.org/abs/2408.10234

arxiv.org

The Unbearable Slowness of Being: Why do we live at 10 bits/s?

This article is about the neural conundrum behind the slowness of human behavior. The information throughput of a human being is about 10 bits/s. In comparison, our sensory systems gather data at ~10^...

100

Derek Mann @damann1.bsky.social · 14/12/2024

Watching my boy score his 2nd try for Siena College in their winning final against Iowa certainly took my mind of my post-op pain! Get in lad!

120

Derek Mann @damann1.bsky.social · 11/12/2024

What is hopefully the final part of my treatment for bowel cancer done. Currently in the fantastic Newcastle NHS Trust Freeman Hospital recovering from surgery to reverse my ileostomy. Operation done 6 months after my first one that removed the tumour. Onwards and Upwards 😊

080

Derek Mann @damann1.bsky.social · 06/12/2024

If you enjoy a film with a strong narrative and great acting this one is highly recommended!

030

Derek Mann @damann1.bsky.social · 05/12/2024

Honoured to be speaking at this event in summer 2025

030

Derek Mann @damann1.bsky.social · 04/12/2024

My 1st gig since my illness, @fontainesdc.bsky.social at Glasgow you were outstanding!

030

Derek Mann @damann1.bsky.social · 20/11/2024

Roman beef stew with tagliatelle 😊

070

Derek Mann @damann1.bsky.social · 20/11/2024

Deadline fast approaching for applications for the CRUK Black Leaders in Cancer PhD Scholarship Programme. Our lab is project number 7 (immune therapy in liver cancer). Read more here and if you know of someone eligible to apply please contact me for more details. www.ncl.ac.uk/cancer/train...

ncl.ac.uk

CRUK Black Leaders PhD Scholarship | Centre for Cancer | Newcastle University

041

Derek Mann @damann1.bsky.social · 19/11/2024

We are designing pre-clinical models of hepatocellular carcinoma (HCC) Read here about how we have innovated ex-vivo murine tumour microenvironment tissue slices to enable drug discovery while addressing the key 3Rs (reduction, refinement, replacement) aims. www.biorxiv.org/content/10.1...

biorxiv.org

Ex-vivo mouse precision cut tumour slices for modelling hepatocellular carcinoma; A 3Rs solution for at-scale drug screening

Disease modelling is vital for improving knowledge of disease mechanisms and for development of new therapeutic molecules and strategies. Modelling the intact living tumour microenvironment (TME) is i...

050

Derek Mann @damann1.bsky.social · 19/11/2024

Our Newcastle University Cancer Centre account is now open, we are community of 100+ cancer researchers focused on discovery and translational oncology. Please follow us on @nucancer.bsky.social for updates/news etc

031

Derek Mann @damann1.bsky.social · 17/11/2024

Walking, the gentlest exercise and medicine 😊

020

Derek Mann @damann1.bsky.social · 16/11/2024

For my first post, a lovely image depicting platelets aggregating onto a neutrophil, which I generated with text to image option on Flux1.AI. Our research group at @newcastleuni.bsky.social are studying these aggregates as immune modulators of the tumour microenvironment in hepatocellular carcinoma

050