Sign in

Physiology and Biophysics

@cuanschutz-dpb.bsky.social
79 followers 57 following 134 posts

Official page of CU Anschutz School of Medicine - Department of Physiology and Biophysics! - linktr.ee/cuanschutz.dpb

PostsRepliesMedia
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 31/08/2026
Congratulations to Drs. Cristin Welle and Marie Banich on their AB Nexus award for "Restoring Executive Function Through AI-Guided Neuromodulation"!
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 28/08/2026
Don't miss our next seminar! Josh McDermott, PhD, presents "New Models of Auditory Intelligence Via Machine Learning" on September 3 at 9:30 AM, Hensel Phelps West Auditorium, Research Complex 1 North.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 26/08/2026
Our seminar schedule is here! Check out the lineup of speakers joining us throughout the year. More Details: medschool.cuanschutz.edu/physiology/events/upcoming-events
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 18/08/2026
We are excited to kick off this year's Seminar Series with a talk by Dr. Anna Dondzillo! Join us for her seminar, "New Models of Auditory Intelligence Via Machine Learning", on Thursday, August 20th, at 9:30AM, in RC1 North, Room 7108.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 18/08/2026
We are excited to kick off this year's Seminar Series with a talk by Dr. Anna Dondzillo! Join us for her seminar, "New Models of Auditory Intelligence Via Machine Learning", on Thursday, August 20th, at 9:30AM, in RC1 North, Room 7108.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 18/08/2026
Exciting news! The Tollin lab has recieved a new NIH R01 grant, titled "Understanding the Link Between Hearing Loss and Alzheimer’s Disease."
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 17/08/2026
Congratulations to Drs. Ben Scholl and Alon Poleg-Polsky on receiving a new NEI grant, "Recurrent interactions in layer 2/3 ferret visual cortex."
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 07/08/2026
Combining Cryo-EM and functional studies, we revealed the mechanism by which this nanobody changes the channel’s shape and closes its pore, the work offers a promising blueprint for developing more precise treatments for autoimmune diseases. Learn more: nature.com/articles/s41467-026-74630-8
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 07/08/2026
This study shows how a nanoantibody can switch off Kv1.3, an ion channel that helps immune cells stay active.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 07/08/2026
Congratulations to the Fernández-Mariño Lab on their latest publication in Nature Communications!
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 30/07/2026
Learn more: pubmed.ncbi.nlm.nih.gov/42380381/
pubmed.ncbi.nlm.nih.gov
Computational Model for Synthesizing Auditory Brainstem Responses to Assess Neuronal Alterations in Aging and Autistic Animal Models - PubMed
These results demonstrate not only the model's accuracy but also its ability to link features of ABR morphology with underlying neuronal properties and suggest follow-up physiological experiments.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 30/07/2026
We are getting closer to understanding the exact mechanisms behind some of the most common hearing deficits. Knowing how these conditions work under the hood brings us one step closer to treatments that actually work.
110
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 30/07/2026
The model accurately recreated known hearing differences seen in Fragile X syndrome (the most common inherited cause of autism) and in aging, and it even predicted a loss of specific brain cells in older animals that was later confirmed under the microscope.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 30/07/2026
Researchers built a computer simulation of thousands of virtual brain cells that mimics how the real auditory brainstem responds to sound, allowing them to recreate ABR waves entirely from simulated brain activity for the first time.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 30/07/2026
When you hear a sound, your brainstem processes it in stages, producing five tiny electrical waves that doctors can record through the skin. This test, called an ABR, is used to check hearing and brain function in both animals and people.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 30/07/2026
🎉 Congratulations to the Klug Lab on their newest publication in JARO (Journal of the Association for Research in Otolaryngology)! 🎉 Huge congrats to the team on this exciting contribution to hearing research! 👏🔬👂
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 24/07/2026
Congratulations to Dr. Cristin Welle and Dr. Ethan Hughes on their new NIH R01 grant for "Pharmacological and Bioelectric Enhancement of Remyelination and Recovery"! Proud to see this work funded out of the Department of Physiology and Biophysics at CU Anschutz. 🎉#CUAnschutz #Neuroscience
210
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 29/06/2026
Congrats to the Klug Lab on receiving a MindFund Mental Health Innovation and Novel Discoveries Award! Support like this keeps our research moving forward.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 15/06/2026
Congratulations to Selin Schamiloglu, Postdoctoral Fellow in the DiGregorio Lab, on being selected as a 2026 Zara Weinberg Leading Edge Fellow! 🎉 We're so proud to have Selin representing our department in this incredible program. Congrats, Selin! 👏
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/06/2026
Congratulations to Drs. Cristin Welle and Dan Denman on receiving the ASPIRE grant award. Joining with them outside of our department are Dan Kramer, Isabelle Buard, and Marie Banich! "Creating a cognitive neuroprosthesis for enhanced executive function"
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
The study shows that error signals aren’t about just one neuron firing, but they depend on network‑level coordination. Synchronized climbing fibers unlock a special circuit that allows the cerebellum to learn efficiently and selectively. www.nature.com/articles/s41...
010
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
When researchers blocked the interneuron‑to‑interneuron inhibition, mice could no longer learn from climbing‑fiber error signals. This proves the disinhibitory pathway is required for cerebellar learning.
110
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
With inhibition lifted, Purkinje cells show larger calcium responses, which are essential for forming new memories. In other words, synchrony lets the cerebellum recognize real errors and update motor commands.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
A single climbing fiber isn’t enough to trigger this disinhibition. But when many climbing fibers fire together, the disinhibitory neurons activate strongly. This synchrony opens a “learning window” in Purkinje cells.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
Researchers found that climbing fibers talk to Purkinje cells (the main output cells). They also activate a specific type of inhibitory interneuron that inhibits other inhibitors. This creates a disinhibitory circuit, a “double negative” that frees Purkinje cells to respond.
110
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
Climbing fibers fire all the time, even when no error happens. If the brain treated every signal as an error, learning would fall apart. So something must filter these signals.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
How does the brain know when a movement was wrong so it can learn from the mistake? In the cerebellum, this “error signal” comes from special neurons called climbing fibers.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 03/06/2026
Congratulations to the Christie lab on the publication of a new paper in Nature Neuroscience! “Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits” Read here: nature.com/articles/s41593-026-02268-2
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 22/05/2026
We would like to extend our thanks to Dr. Eduardo Perozo for his presentation for our 26th annual A.R. Martin Lectureship! We would also like to thank Dr. John Bankston for hosting our wonderful speaker. Collaborative efforts like these strengthen scientific community & help drive discovery!
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 20/05/2026
Please join us on Thursday, May 21st, for the 26th Annual A.R. Martin lecture hosted by our department. "Prestin Conformational Dynamics and the Molecular Basis of Auditory Amplification” ⏰9:30-10:20AM 📍Hensel Phelps West Auditorium
010
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 04/05/2026
Join us this Thursday, May 7th, at 9:30AM, for a seminar with Dr. Gaby Maimon in the Hensel Phelps West Auditorium. "Functional logic of a cognitive brain system."
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 21/04/2026
Beating every published Phase II benchmark with 229 days from IND submission to first enrollment — in an indication with 800 million patients and no approved treatment.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 21/04/2026
Parley Neurotech & CU Anschutz Enroll First Patient in Clinical Trial Targeting the #1 Modifiable Risk Factor for Dementia!
110
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 21/04/2026
Specifically, they want to find out whether the treatment works at different ages, how long the hearing improvements last, and how to make the treatment as effective as possible. The ultimate goal is to turn these lab findings into a real treatment option for patients.
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 21/04/2026
Together with Drs. Ethan Hughes and Katie Rennie, the research project focuses on clemastine, an over-the-counter antihistamine that earlier work suggests may help restore a form of hearing loss that commonly happens in aging. This will allow to dig deeper into why & how this drug appears to work.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 21/04/2026
Researchers Dr. Achim Klug and Dr. Dan Tollin have received a multi-year federal grant from the National Institutes of Health (NIH) to study a potential new treatment for age-related hearing loss.
110
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 21/04/2026
CU Anschutz Communications Highlights Our CAPD Clinical Trial!” Spotlight on the Klug lab’s CAPD hearing-loss therapy now entering human trials 🔗 news.cuanschutz.edu/news-stories/cu-anschutz-launches-clinical-trial-for-capd-therapy-that-reversed-hearing-loss-in-models
news.cuanschutz.edu
CU Anschutz Launches Clinical Trial for CAPD Therapy That Reversed Hearing Loss in Models
CU Anschutz researchers are offering hope to people with central hearing loss through a novel combination treatment of an oral drug and an acoustic therapy
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 16/04/2026
Why This Matters This could explain cases of hearing loss that currently have no clear cause. It also points to a new angle for treatment, not just looking at which genes someone has, but whether those genes are showing up in the right proportions. 🔗 pnas.org/doi/full/10.1073/pnas.2531564123
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 16/04/2026
When the Balance Tips When scientists deleted one version in mice, they went severely deaf. When they overloaded the other version, the same thing happened. It turns out that having too much or too little of either version causes the hair cells to collapse.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 16/04/2026
The Manager Gene A protein called RBM24 acts like a foreman, keeping those hair cells healthy and organized. But here's the twist: it comes in two versions, and you need both in the right amounts.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 16/04/2026
Deep inside your ear are microscopic hair cells. They vibrate with sound waves and turn them into signals your brain can understand. No hair cells = no hearing.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 16/04/2026
🔔 New publication by the Peng lab! 🔔 Alternative splicing of the Rbm24 gene is essential for cochlear hair cell stereocilia integrity and hearing function in mice 🔗 Read it in full: pnas.org/doi/full/10.1073/pnas.2531564123
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/04/2026
Thank you for your interest in our research! Read the full paper: pubmed.ncbi.nlm.nih.gov/41830477/
pubmed.ncbi.nlm.nih.gov
Non-uniform spike count shared variability in the mouse early visual system - PubMed
Sensory stimuli are represented by the joint activity of large populations of neurons across the mammalian cortex. Information in such responses can be affected by trial-to-trial variability. Because that variability is not independent between neurons, it has the potential to improve or degrade the …
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/04/2026
At slower timescales (~100 ms), shared variability didn’t change much. In V1, it barely affected how much visual information was available. Shared variability isn’t random, it carries structure and meaning. Different overlapping neuron groups carry different pieces of visual information.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/04/2026
Shared variability was low‑dimensional. These patterns could either help neurons work together or make them redundant. At very fine timescales (<10 ms), shared variability actually improved information. Decoders could use these tiny fluctuations to sharpen vision.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/04/2026
Researchers used Neuropixels probes to listen to hundreds of neurons at once. They recorded from two connected visual areas in awake mice: V1 & dLGN. The team measured shared variability from milliseconds to seconds Different timescales revealed different patterns of how neurons “co‑fluctuate"
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/04/2026
How does the brain turn messy, noisy signals into clear vision? Neurons don’t fire the same way every time. That variability might help or hurt how we see. Neurons don’t work alone. Their moment‑to‑moment fluctuations are shared. This shared variability can boost information… or scramble it.
100
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 08/04/2026
New Publication by the Denman Lab! "Non-uniform spike count shared variability in the mouse early visual system" Read the full paper: pubmed.ncbi.nlm.nih.gov/41830477/
110
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 02/04/2026
Join us for a seminar with Dr. Brice Bathellier! “The Transformations of Sound Representations in the Auditory System and Applications to Auditory Restoration by Central Neurostimulation” 🕤 9:30 AM 📅 April 27 📍 RC1 North, Room 7108
000
Physiology and Biophysics @cuanschutz-dpb.bsky.social · 27/03/2026
This Women’s History Month, we honor the remarkable women of our Department of Physiology & Biophysics. Here’s to the women advancing science, expanding knowledge, and inspiring all of us to push the boundaries of what’s possible. 💪⚛️👩‍🔬
010