iiinova — where your digital self keeps evolving

🧪 We've published our first paper on Gardnerella. There is extensive phase variation in all the Gardnerella species we examined. It effects surface proteins, toxin production, and human cervix infection ex vivo. doi.org/10.1128/msph...

Colonies of the bacteria Gardnerella, strain 3336, grow on an agar plate and appear as large or small colonies (left panel). The number of Gardnerella surviving in an infection of huaman cervix tissue in the lab is depicted in a bar graph, and the number of small colony variants that survive is greater than those of the large colony variants (right panel).

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Dr. Caitlin Pepperell @csp.bsky.social · 19/04/2024

Hot off the press! Our research on transcriptome evolution of mega-pathogen M. tuberculosis: journals.plos.org/plospathogen... aka what happens to the transcriptome when you select for biofilm growth?

journals.plos.org

Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth

Author summary Understanding mechanisms of resistance and tolerance in Mycobacterium tuberculosis (M. tb) can help us develop new treatments that capitalize on M. tb’s vulnerabilities. Here we used tr...

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Dr. Caitlin Pepperell @csp.bsky.social · 29/09/2023

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Reposted by Dr. Caitlin Pepperell

Vaughn Cooper @vscooper.micropopbio.org · 07/09/2023

Whoa. Redux of a paper from 12 years ago with the opposite effect: sweeps and persistence not brief perturbation 🧪🧬

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