Sign in

Cryptic Prophage (phage 🧬🪤 in 🦠)

@crypticprophage.bsky.social
329 followers 144 following 61 posts

TA systems stop phages (discovered '96), phages create persisters (discovered '23), E. c. CRISPR regulates cryptic prophages (discovered '21), indole = inter-kingdom signal, AI2 increases biofilm & TqsA exports (Thomas K. Wood, endowed prof, H118, 361 pub)

PostsRepliesMedia
Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage.bsky.social · 14/06/2026
Compare doi:10.1111/1462-2920.14093 and doi.org/10.1016/j.is..., etc.
000
Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage.bsky.social · 12/05/2026
www.nature.com/articles/s41... Add'l evidence that cells in growth arrest (here stationary phase, 12 hr) recover by reviving ribosomes, as shown in 2018 for persister cells using single-cell studies (not cited) and further elaborated in 2020 (doi 10.1016/j.isci.2019.100792, not cited).
000
Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage.bsky.social · 06/02/2026
010
Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage.bsky.social · 12/10/2025
nature.com/articles/s41564-025-02124-2 BPOET: 1st high-throughput search (10,000 cmpds), resuscitates persisters (2020) with mechanism of activating hibernating ribosomes via 23S rRNA pseudouridine synthase RluD (E. coli, doi:10.1111/1462-2920.14828), cited, but not in context vs. new search:
010
Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage.bsky.social · 29/09/2025
Uracil first shown 2009 to be a QS signal in P. a. & UMP path important for QS & virulence. Moreover, 5-fluorouracil is a potent QS quencher & is the first QQ compound used commercially (for catheters). Uracil also is a signal in the Drosophila GI tract.
000
Cryptic Prophage (phage 🧬🪤 in 🦠) @crypticprophage.bsky.social · 21/11/2024
doi.org/10.1038/s415... Just my opinion, based on what I consider sound research in a field with much noise due to studying dying cells, but please see the attached list of the usual errors from this lab in their Nature Rev Micro persister review.
000