iiinova — where your digital self keeps evolving

Cameron Roots @croots.me · 09/01/2025

Cool preprint from @thisismadani.bsky.social and team at Profluent on AI-optimized CAS proteins. I could see insights from this being used for many more protein-nucleic acid protein engineering projects. www.biorxiv.org/content/10.1...

biorxiv.org

Engineering of CRISPR-Cas PAM recognition using deep learning of vast evolutionary data

CRISPR-Cas enzymes must recognize a protospacer-adjacent motif (PAM) to edit a genomic site, significantly limiting the range of targetable sequences in a genome. Machine learning-based protein engine...

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