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Covalent Modifiers

@covalentmod.bsky.social
895 followers 64 following 553 posts

A BlueSky feed for the blog covalentmodifiers.blogspot.com. Discusses the covalent modification of proteins, particularly with regards to inhibitors.

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Covalent Modifiers @covalentmod.bsky.social · 22/02/2025
Site-specific activation of the proton pumpinhibitor rabeprazole by tetrathiolate zinccentres covalentmodifiers.blogspot.com/2025…
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Covalent Modifiers @covalentmod.bsky.social · 31/01/2025
Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group covalentmodifiers.blogspot.com/2025…
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Covalent Modifiers @covalentmod.bsky.social · 20/01/2025
Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity covalentmodifiers.blogspot.com/2025…
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Covalent Modifiers @covalentmod.bsky.social · 14/01/2025
Covalent Plant Natural Product that Potentiates Antitumor Immunity covalentmodifiers.blogspot.com/2025…
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Covalent Modifiers @covalentmod.bsky.social · 14/12/2024
Exploring Extended Warheads toward Developing Cysteine-Targeted Covalent Kinase Inhibitors covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 03/12/2024
Open-source Electrophilic Fragment Screening Platform to Identify Chemical Starting Points for UCHL1 Covalent Inhibitors covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 25/11/2024
Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 15/10/2024
Potent Inhibition and Rapid Photoactivation of Endogenous Bruton’s Tyrosine Kinase Activity in Native Cells via Opto-Covalent Modulators covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 10/10/2024
Reversible covalent c-Jun N-terminal kinase inhibitors targeting a specific cysteine by precision-guided Michael-acceptor warheads covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 01/10/2024
Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 01/10/2024
Activity-Based Acylome Profiling with N-(Cyanomethyl)-N-(phenylsulfonyl)amides for Targeted Lysine Acylation and Post-Translational Control of Protein Function in Cells covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 30/09/2024
Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 26/09/2024
Peptide and Protein Cysteine Modification Enabled by Hydrosulfuration of Ynamide covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 24/09/2024
An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 19/09/2024
Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 14/09/2024
Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 04/09/2024
From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 01/09/2024
SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 28/08/2024
Targeted Protein Localization by Covalent 14–3–3 Recruitment covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 27/08/2024
Aminomethyl Salicylaldehydes Lock onto a Surface Lysine by Forming an Extended Intramolecular Hydrogen Bond Network covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 21/08/2024
Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation and Pyroptosis covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 14/08/2024
Electrophilic proximity-inducing synthetic adapters enhance universal T cell function by covalently enforcing immune receptor signaling [@RulloLab] covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 14/08/2024
Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells [@EvertNjomen] covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 13/08/2024
Discovery of Thioether-Cyclized Macrocyclic Covalent Inhibitors by mRNA Display covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 05/08/2024
Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 02/08/2024
Graph neural networks for identifying protein-reactive compounds covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 01/08/2024
Sophisticated natural products as antibiotics covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 01/08/2024
Template-assisted covalent modification underlies activity of covalent molecular glues covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 30/07/2024
Direct RAS inhibitors turn 10 covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 30/07/2024
Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 26/07/2024
DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 16/07/2024
Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRasG12C covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 16/07/2024
High-Throughput Covalent Modifier Screening with Acoustic Ejection Mass Spectrometry covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 06/07/2024
Recruitment of FBXO22 for targeted degradation of NSD2 [@CherylArrowsmi1] covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 05/07/2024
Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53 covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 01/07/2024
Prolonged Activation of the GLP-1 Receptor via Covalent Capture covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 30/06/2024
RETURN TO ARTICLES ASAPPREVARTICLENEXT N-Acyl-N-Alkyl Sulfonamide Probes for Ligand-Directed Covalent Labeling of GPCRs: The Adenosine A2B Receptor as Case Study covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 30/06/2024
Development of a Dual Factor Activatable Covalent Targeted Photoacoustic Imaging Probe for Tumor Imaging covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 29/06/2024
Design of a covalent protein-protein interaction inhibitor of SRPKs to suppress angiogenesis and invasion of cancer cells covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 28/06/2024
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1 covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 25/06/2024
covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 07/06/2024
Covalent Degrader of the Oncogenic Transcription Factor β-Catenin covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 31/05/2024
Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 31/05/2024
Inclusive Pattern Generation Protocols to Decode Thiol-Mediated Uptake covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 23/05/2024
Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 22/05/2024
Targeting PfCLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatmen covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 22/05/2024
DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 21/05/2024
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 14/05/2024
Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells covalentmodifiers.blogspot.com/2024…
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Covalent Modifiers @covalentmod.bsky.social · 09/05/2024
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis covalentmodifiers.blogspot.com/2024…
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