Multiple Sequence Alignments (MSAs) were also powerful for zero-shot design! Without any assay data, and even without structure or large-scale pretraining, we were able to design improved NucB variants with as many as 9 mutations from the wildtype.
Neil Thomas
@countablyfinite.bsky.social
909 followers 478 following 18 posts
AI x Biology EvolutionaryScale / Biohub PhD UC Berkeley Prev: Google X, 23andMe, thomas-a-neil.github.io
